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- W3113135314 abstract "Insulin was isolated in the period from May 17, 1921 to January 23, 1922 by Banting, Best, Collip and Macleod. The first successful clinical trial was on January 23, 1922 and insulin therapy continues to play a central role in the treatment of diabetes. Research on insulin also continues with the development of new insulin analogues and devices for delivery, as well as studies of the regulation of its secretion and how it exerts its biological actions. Insulin is the major biosynthetic and secretory of the pancreatic beta cell accounting for 10% of the total protein and 50% or more of the total protein synthesis when maximally stimulated (~1 × 106 molecules/min). Insulin biosynthesis induces ER stress that is aggravated by increasing demand or the synthesis of mutant insulin protein. We have developed a model system in the fruit fly Drosophila melanogaster that allows us to take an agnostic approach using the powerful genetic tools offered by the fruit fly to study the effects of mutant proinsulin proteins on cell function and survival. These studies could lead to new approaches for preserving beta-cell function in patients with diabetes." @default.
- W3113135314 created "2020-12-21" @default.
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- W3113135314 date "2019-01-01" @default.
- W3113135314 modified "2023-09-23" @default.
- W3113135314 title "PL-1 : Insulin - an unfinished story" @default.
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