FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113140135> ?p ?o ?g. }

• W3113140135 abstract "Abstract Background Detecting amyloid‐β plaque accumulation in individuals who are initially amyloid negative can help understand the earliest stages of Alzheimer’s disease (AD). This study aimed to determine sample sizes that would be needed to detect statistically significant longitudinal changes using semi‐ (standard uptake value ratios; SUVR) and quantitative (distribution volume ratios; DVR) PET measures at global and regional levels. Method [ 11 C]PIB scans of 239 cognitively normal (CN) subjects (mean age 63.4 ± 9.3 years) in the OASIS‐3 data‐set, who underwent at least two PET scans, were included. Regional SUVR and DVR were extracted using a cortical composite as target, and cerebellar gray matter as reference region (PUP, https://github.com/ysu001/PUP). PET positivity was defined by Gaussian Mixture Modelling of the global SUVR (SUVR>1.16). Annual accumulation rates were calculated using linear regression, and sample sizes to detect a significant longitudinal change (alpha = 0.05; 1‐beta = 0.80) were determined with the sampsizepwr function in Matlab. The percentage of accumulators (rates of change >2SD of negative group) was also computed. Result As expected, rates of change were higher in subjects with positive PET at baseline, and APOE‐ε4 carriership increased accumulation rates in both negative and positive groups (Table 1). Using either metric, orbitofrontal and precuneus displayed the highest rates of change in the negative group. SUVR rendered higher accumulation rates than DVR, but also displayed higher variability. As a consequence, to detect 0.22% early accumulation (mean of negative group), global DVR required N = 584 compared with N = 917 for global SUVR (Figure 1). In addition, DVR classified 13% of subjects as accumulators compared with 9% for SUVR. Finally, precuneus and orbitofrontal regions classify more subjects as accumulators than global SUVR, i.e. 17 and 25%, respectively. Conclusion As compared to SUVR, DVR can reduce the sample size needed to detect longitudinal amyloid changes by approximately 40% in amyloid negative populations. Additional improvements in statistical power can be achieved by focusing on precuneus and orbitofrontal regions." @default.
• W3113140135 created "2020-12-21" @default.
• W3113140135 creator A5000884161 @default.
• W3113140135 creator A5014248780 @default.
• W3113140135 creator A5036068671 @default.
• W3113140135 creator A5042212695 @default.
• W3113140135 creator A5063066226 @default.
• W3113140135 creator A5065258380 @default.
• W3113140135 creator A5066508710 @default.
• W3113140135 creator A5076585111 @default.
• W3113140135 creator A5080344209 @default.
• W3113140135 date "2020-12-01" @default.
• W3113140135 modified "2023-10-06" @default.
• W3113140135 title "Dynamic PET imaging reduces sample sizes to detect longitudinal amyloid accumulation" @default.
• W3113140135 doi "https://doi.org/10.1002/alz.042623" @default.
• W3113140135 hasPublicationYear "2020" @default.
• W3113140135 type Work @default.
• W3113140135 sameAs 3113140135 @default.
• W3113140135 citedByCount "1" @default.
• W3113140135 countsByYear W31131401352020 @default.
• W3113140135 crossrefType "journal-article" @default.
• W3113140135 hasAuthorship W3113140135A5000884161 @default.
• W3113140135 hasAuthorship W3113140135A5014248780 @default.
• W3113140135 hasAuthorship W3113140135A5036068671 @default.
• W3113140135 hasAuthorship W3113140135A5042212695 @default.
• W3113140135 hasAuthorship W3113140135A5063066226 @default.
• W3113140135 hasAuthorship W3113140135A5065258380 @default.
• W3113140135 hasAuthorship W3113140135A5066508710 @default.
• W3113140135 hasAuthorship W3113140135A5076585111 @default.
• W3113140135 hasAuthorship W3113140135A5080344209 @default.
• W3113140135 hasBestOaLocation W31131401351 @default.
• W3113140135 hasConcept C105795698 @default.
• W3113140135 hasConcept C126322002 @default.
• W3113140135 hasConcept C129848803 @default.
• W3113140135 hasConcept C2989005 @default.
• W3113140135 hasConcept C33923547 @default.
• W3113140135 hasConcept C71924100 @default.
• W3113140135 hasConceptScore W3113140135C105795698 @default.
• W3113140135 hasConceptScore W3113140135C126322002 @default.
• W3113140135 hasConceptScore W3113140135C129848803 @default.
• W3113140135 hasConceptScore W3113140135C2989005 @default.
• W3113140135 hasConceptScore W3113140135C33923547 @default.
• W3113140135 hasConceptScore W3113140135C71924100 @default.
• W3113140135 hasIssue "S4" @default.
• W3113140135 hasLocation W31131401351 @default.
• W3113140135 hasOpenAccess W3113140135 @default.
• W3113140135 hasPrimaryLocation W31131401351 @default.
• W3113140135 hasRelatedWork W1506200166 @default.
• W3113140135 hasRelatedWork W1995515455 @default.
• W3113140135 hasRelatedWork W2048182022 @default.
• W3113140135 hasRelatedWork W2080531066 @default.
• W3113140135 hasRelatedWork W2335450448 @default.
• W3113140135 hasRelatedWork W2748952813 @default.
• W3113140135 hasRelatedWork W2899084033 @default.
• W3113140135 hasRelatedWork W3031052312 @default.
• W3113140135 hasRelatedWork W3032375762 @default.
• W3113140135 hasRelatedWork W3108674512 @default.
• W3113140135 hasVolume "16" @default.
• W3113140135 isParatext "false" @default.
• W3113140135 isRetracted "false" @default.
• W3113140135 magId "3113140135" @default.
• W3113140135 workType "article" @default.