Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113145963> ?p ?o ?g. }
- W3113145963 endingPage "M59" @default.
- W3113145963 startingPage "M51" @default.
- W3113145963 abstract "Abstract Atrial fibrillation (AF) and stroke are inextricably connected, with classical Virchow pathophysiology explaining thromboembolism through blood stasis in the fibrillating left atrium. This conceptualization has been reinforced by the remarkable efficacy of oral anticoagulant (OAC) for stroke prevention in AF. A number of observations showing that the presence of AF is neither necessary nor sufficient for stroke, cast doubt on the causal role of AF as a villain in vascular brain injury (VBI). The requirement for additional risk factors before AF increases stroke risk; temporal disconnect of AF from a stroke in patients with no AF for months before stroke during continuous ECG monitoring but manifesting AF only after stroke; and increasing recognition of the role of atrial cardiomyopathy and atrial substrate in AF-related stroke, and also stroke without AF, have led to rethinking the pathogenetic model of cardioembolic stroke. This is quite separate from recognition that in AF, shared cardiovascular risk factors can lead both to non-embolic stroke, or emboli from the aorta and carotid arteries. Meanwhile, VBI is now expanded to include dementia and cognitive decline: research is required to see if reduced by OAC. A changed conceptual model with less focus on the arrhythmia, and more on atrial substrate/cardiomyopathy causing VBI both in the presence or absence of AF, is required to allow us to better prevent AF-related VBI. It could direct focus towards prevention of the atrial cardiomyopathy though much work is required to better define this entity before the balance between AF as villain or bystander can be determined." @default.
- W3113145963 created "2020-12-21" @default.
- W3113145963 creator A5005536581 @default.
- W3113145963 creator A5005773814 @default.
- W3113145963 creator A5064975333 @default.
- W3113145963 creator A5090270823 @default.
- W3113145963 date "2020-11-01" @default.
- W3113145963 modified "2023-09-23" @default.
- W3113145963 title "Atrial fibrillation: villain or bystander in vascular brain injury" @default.
- W3113145963 cites W140098974 @default.
- W3113145963 cites W155477934 @default.
- W3113145963 cites W1566134466 @default.
- W3113145963 cites W1747765887 @default.
- W3113145963 cites W1893471362 @default.
- W3113145963 cites W1924098982 @default.
- W3113145963 cites W1927032517 @default.
- W3113145963 cites W1962579529 @default.
- W3113145963 cites W1963940525 @default.
- W3113145963 cites W1970242617 @default.
- W3113145963 cites W1971152469 @default.
- W3113145963 cites W1975546944 @default.
- W3113145963 cites W1977385197 @default.
- W3113145963 cites W1987466684 @default.
- W3113145963 cites W1994223985 @default.
- W3113145963 cites W1996490798 @default.
- W3113145963 cites W1999468381 @default.
- W3113145963 cites W2013057449 @default.
- W3113145963 cites W2013832146 @default.
- W3113145963 cites W2013913486 @default.
- W3113145963 cites W2013956194 @default.
- W3113145963 cites W2018147535 @default.
- W3113145963 cites W2018986021 @default.
- W3113145963 cites W2020682484 @default.
- W3113145963 cites W2023614959 @default.
- W3113145963 cites W2024497977 @default.
- W3113145963 cites W2031605707 @default.
- W3113145963 cites W2045084738 @default.
- W3113145963 cites W2051923490 @default.
- W3113145963 cites W2053292521 @default.
- W3113145963 cites W2060441994 @default.
- W3113145963 cites W2061546208 @default.
- W3113145963 cites W2064798406 @default.
- W3113145963 cites W2067910461 @default.
- W3113145963 cites W2072376428 @default.
- W3113145963 cites W2079630168 @default.
- W3113145963 cites W2086408379 @default.
- W3113145963 cites W2089212627 @default.
- W3113145963 cites W2092980394 @default.
- W3113145963 cites W2101074565 @default.
- W3113145963 cites W2102904190 @default.
- W3113145963 cites W2106940213 @default.
- W3113145963 cites W2112422199 @default.
- W3113145963 cites W2114672576 @default.
- W3113145963 cites W2116427214 @default.
- W3113145963 cites W2124087651 @default.
- W3113145963 cites W2125693777 @default.
- W3113145963 cites W2138595885 @default.
- W3113145963 cites W2140485936 @default.
- W3113145963 cites W2142639349 @default.
- W3113145963 cites W2143888546 @default.
- W3113145963 cites W2144677817 @default.
- W3113145963 cites W2145263956 @default.
- W3113145963 cites W2145908364 @default.
- W3113145963 cites W2147018083 @default.
- W3113145963 cites W2151557446 @default.
- W3113145963 cites W2152323931 @default.
- W3113145963 cites W2154658516 @default.
- W3113145963 cites W2155634079 @default.
- W3113145963 cites W2155690271 @default.
- W3113145963 cites W2157813392 @default.
- W3113145963 cites W2160835573 @default.
- W3113145963 cites W2161212353 @default.
- W3113145963 cites W2162586165 @default.
- W3113145963 cites W2162687414 @default.
- W3113145963 cites W2168813311 @default.
- W3113145963 cites W2173055315 @default.
- W3113145963 cites W2194176361 @default.
- W3113145963 cites W2197915765 @default.
- W3113145963 cites W2218210263 @default.
- W3113145963 cites W2285069016 @default.
- W3113145963 cites W2286228684 @default.
- W3113145963 cites W2295490840 @default.
- W3113145963 cites W2297310737 @default.
- W3113145963 cites W2303874590 @default.
- W3113145963 cites W2321786110 @default.
- W3113145963 cites W2342046766 @default.
- W3113145963 cites W2345501265 @default.
- W3113145963 cites W2346686972 @default.
- W3113145963 cites W2406392761 @default.
- W3113145963 cites W2441025241 @default.
- W3113145963 cites W2509478971 @default.
- W3113145963 cites W2518330835 @default.
- W3113145963 cites W2530912511 @default.
- W3113145963 cites W2532914293 @default.
- W3113145963 cites W2555608762 @default.
- W3113145963 cites W2566015711 @default.
- W3113145963 cites W2568353100 @default.
- W3113145963 cites W2589508596 @default.