FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113158584> ?p ?o ?g. }

• W3113158584 endingPage "118882" @default.
• W3113158584 startingPage "118882" @default.
• W3113158584 abstract "Cilostazol (Cilo), a phosphodiesterase-III inhibitor, has signified its efficacy against different ischemia/reperfusion (IS/RE) models. Nevertheless, it has not fully illuminated its potential effect against intestinal IS/RE-induced lung injury. Consequently, the study was fashioned to evaluate the feasible mechanism of action of Cilo against intestinal IS/RE-induced lung injury. Wistar rats were treated with Cilo (0.1 g/kg, p.o.) or with a vehicle for 14 days prior to IS/RE, induced by clamping of the superior mesenteric artery for 30 min with subsequent clamp removal for 2 h. The mechanistic study disclosed that Cilo protected the two studied organs, viz., lung, and intestine partially by intensifying the expression/content of PPAR-γ accompanied by reducing the expression/content of NF-қB-p65 and STAT3. In addition to normalizing MDA, iNOS, and NOx, the Cilo antioxidant power was confirmed by intensifying tissues content of the total antioxidant capacity. With regard to the anti-inflammatory effect, Cilo reduced the effects of TNF-α, IL-6, and ICAM-1, which were reflected in MPO activity. Furthermore, Cilo had an anti-apoptotic attribute demonstrated by enhancing Bcl-2 content and lessening caspase-3 level. Cilo provided conceivable protective mechanisms to modulate events concomitant with mesenteric IS/RE partly by modulating oxidative stress, inflammation, and apoptosis feasibly via the participation of PPAR-γ, STAT3, and NF-κB p65 signaling pathways." @default.
• W3113158584 created "2020-12-21" @default.
• W3113158584 creator A5002177037 @default.
• W3113158584 creator A5030555169 @default.
• W3113158584 creator A5054877812 @default.
• W3113158584 creator A5079762847 @default.
• W3113158584 date "2021-02-01" @default.
• W3113158584 modified "2023-10-18" @default.
• W3113158584 title "Cilostazol mitigates mesenteric ischemia/reperfusion-induced lung lesion: Contribution of PPAR-γ, NF-κB, and STAT3 crosstalk" @default.
• W3113158584 cites W1965383347 @default.
• W3113158584 cites W1971956518 @default.
• W3113158584 cites W1977685280 @default.
• W3113158584 cites W1982874612 @default.
• W3113158584 cites W1986563000 @default.
• W3113158584 cites W1993550950 @default.
• W3113158584 cites W1998915656 @default.
• W3113158584 cites W2000127507 @default.
• W3113158584 cites W2005074643 @default.
• W3113158584 cites W2008757142 @default.
• W3113158584 cites W2012451275 @default.
• W3113158584 cites W2020358486 @default.
• W3113158584 cites W2020766314 @default.
• W3113158584 cites W2038254164 @default.
• W3113158584 cites W2040653998 @default.
• W3113158584 cites W2043872167 @default.
• W3113158584 cites W2048234914 @default.
• W3113158584 cites W2052414359 @default.
• W3113158584 cites W2054172604 @default.
• W3113158584 cites W2059699981 @default.
• W3113158584 cites W2059738518 @default.
• W3113158584 cites W2061434349 @default.
• W3113158584 cites W2082647290 @default.
• W3113158584 cites W2086667809 @default.
• W3113158584 cites W2101804755 @default.
• W3113158584 cites W2114615028 @default.
• W3113158584 cites W2123401718 @default.
• W3113158584 cites W2144164696 @default.
• W3113158584 cites W2146703628 @default.
• W3113158584 cites W2153555611 @default.
• W3113158584 cites W2173635835 @default.
• W3113158584 cites W2564326916 @default.
• W3113158584 cites W2564944135 @default.
• W3113158584 cites W2576965915 @default.
• W3113158584 cites W2600932923 @default.
• W3113158584 cites W2613535326 @default.
• W3113158584 cites W2794119044 @default.
• W3113158584 cites W2893356404 @default.
• W3113158584 cites W2936933003 @default.
• W3113158584 cites W2943902917 @default.
• W3113158584 cites W2965614975 @default.
• W3113158584 cites W3003566014 @default.
• W3113158584 cites W3011547660 @default.
• W3113158584 cites W3073893711 @default.
• W3113158584 doi "https://doi.org/10.1016/j.lfs.2020.118882" @default.
• W3113158584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33310046" @default.
• W3113158584 hasPublicationYear "2021" @default.
• W3113158584 type Work @default.
• W3113158584 sameAs 3113158584 @default.
• W3113158584 citedByCount "10" @default.
• W3113158584 countsByYear W31131585842021 @default.
• W3113158584 countsByYear W31131585842022 @default.
• W3113158584 countsByYear W31131585842023 @default.
• W3113158584 crossrefType "journal-article" @default.
• W3113158584 hasAuthorship W3113158584A5002177037 @default.
• W3113158584 hasAuthorship W3113158584A5030555169 @default.
• W3113158584 hasAuthorship W3113158584A5054877812 @default.
• W3113158584 hasAuthorship W3113158584A5079762847 @default.
• W3113158584 hasConcept C126322002 @default.
• W3113158584 hasConcept C185592680 @default.
• W3113158584 hasConcept C190283241 @default.
• W3113158584 hasConcept C2776914184 @default.
• W3113158584 hasConcept C2777628954 @default.
• W3113158584 hasConcept C2777714996 @default.
• W3113158584 hasConcept C2779820409 @default.
• W3113158584 hasConcept C2781046184 @default.
• W3113158584 hasConcept C55493867 @default.
• W3113158584 hasConcept C71924100 @default.
• W3113158584 hasConcept C98274493 @default.
• W3113158584 hasConceptScore W3113158584C126322002 @default.
• W3113158584 hasConceptScore W3113158584C185592680 @default.
• W3113158584 hasConceptScore W3113158584C190283241 @default.
• W3113158584 hasConceptScore W3113158584C2776914184 @default.
• W3113158584 hasConceptScore W3113158584C2777628954 @default.
• W3113158584 hasConceptScore W3113158584C2777714996 @default.
• W3113158584 hasConceptScore W3113158584C2779820409 @default.
• W3113158584 hasConceptScore W3113158584C2781046184 @default.
• W3113158584 hasConceptScore W3113158584C55493867 @default.
• W3113158584 hasConceptScore W3113158584C71924100 @default.
• W3113158584 hasConceptScore W3113158584C98274493 @default.
• W3113158584 hasLocation W31131585841 @default.
• W3113158584 hasOpenAccess W3113158584 @default.
• W3113158584 hasPrimaryLocation W31131585841 @default.
• W3113158584 hasRelatedWork W1965410373 @default.
• W3113158584 hasRelatedWork W2089535392 @default.
• W3113158584 hasRelatedWork W2151302896 @default.
• W3113158584 hasRelatedWork W2157333908 @default.
• W3113158584 hasRelatedWork W2181051065 @default.
• W3113158584 hasRelatedWork W2224767656 @default.

• next