Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113163938> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3113163938 abstract "Abstract Eukaryotic genomes gradually gain noncoding regions when advancing evolution and human genome actively transcribes >90% of its noncoding regions 1 , suggesting their criticality in evolutionary human genome. Yet <1% of them have been functionally characterized 2 , leaving most human genome in dark. Here we systematically decode endogenous lncRNAs located in unannotated regions of human genome and decipher a distinctive functional regime of lncRNAs hidden in massive RNAseq data. LncRNAs divergently distribute across chromosomes, independent of protein-coding regions. Their transcriptions barely initiate on promoters through polymerase II, but mostly on enhancers. Yet conventional enhancer activators(e.g. H3K4me1) only account for a small proportion of lncRNA activation, suggesting alternatively unknown mechanisms initiating the majority of lncRNAs. Meanwhile, lncRNA-self regulation also notably contributes to lncRNA activation. LncRNAs trans-regulate broad bioprocesses, including transcription and RNA processing, cell cycle, respiration, response to stress, chromatin organization, post-translational modification, and development. Overall lncRNAs govern their owned regime distinctive from protein’s." @default.
- W3113163938 created "2020-12-21" @default.
- W3113163938 creator A5027024205 @default.
- W3113163938 creator A5084096966 @default.
- W3113163938 date "2020-12-07" @default.
- W3113163938 modified "2023-10-17" @default.
- W3113163938 title "Distinctive functional regime of endogenous lncRNAs in dark regions of human genome" @default.
- W3113163938 cites W1981030303 @default.
- W3113163938 cites W1999491723 @default.
- W3113163938 cites W1999746344 @default.
- W3113163938 cites W2015953751 @default.
- W3113163938 cites W2026906939 @default.
- W3113163938 cites W2083279359 @default.
- W3113163938 cites W2095884976 @default.
- W3113163938 cites W2096083625 @default.
- W3113163938 cites W2119867435 @default.
- W3113163938 cites W2139658526 @default.
- W3113163938 cites W2157911987 @default.
- W3113163938 cites W2160333540 @default.
- W3113163938 cites W2338433671 @default.
- W3113163938 cites W2566261809 @default.
- W3113163938 cites W2593488635 @default.
- W3113163938 cites W2769011958 @default.
- W3113163938 cites W2776802713 @default.
- W3113163938 cites W2909125394 @default.
- W3113163938 cites W2952328530 @default.
- W3113163938 cites W2958479675 @default.
- W3113163938 cites W3010473795 @default.
- W3113163938 cites W3106029267 @default.
- W3113163938 cites W3194959339 @default.
- W3113163938 cites W4254457389 @default.
- W3113163938 doi "https://doi.org/10.1101/2020.12.06.413880" @default.
- W3113163938 hasPublicationYear "2020" @default.
- W3113163938 type Work @default.
- W3113163938 sameAs 3113163938 @default.
- W3113163938 citedByCount "1" @default.
- W3113163938 countsByYear W31131639382022 @default.
- W3113163938 crossrefType "posted-content" @default.
- W3113163938 hasAuthorship W3113163938A5027024205 @default.
- W3113163938 hasAuthorship W3113163938A5084096966 @default.
- W3113163938 hasBestOaLocation W31131639381 @default.
- W3113163938 hasConcept C101762097 @default.
- W3113163938 hasConcept C104317684 @default.
- W3113163938 hasConcept C111936080 @default.
- W3113163938 hasConcept C138885662 @default.
- W3113163938 hasConcept C141231307 @default.
- W3113163938 hasConcept C150194340 @default.
- W3113163938 hasConcept C179926584 @default.
- W3113163938 hasConcept C197077220 @default.
- W3113163938 hasConcept C41895202 @default.
- W3113163938 hasConcept C54355233 @default.
- W3113163938 hasConcept C62203573 @default.
- W3113163938 hasConcept C67705224 @default.
- W3113163938 hasConcept C70721500 @default.
- W3113163938 hasConcept C83640560 @default.
- W3113163938 hasConcept C86339819 @default.
- W3113163938 hasConcept C86803240 @default.
- W3113163938 hasConceptScore W3113163938C101762097 @default.
- W3113163938 hasConceptScore W3113163938C104317684 @default.
- W3113163938 hasConceptScore W3113163938C111936080 @default.
- W3113163938 hasConceptScore W3113163938C138885662 @default.
- W3113163938 hasConceptScore W3113163938C141231307 @default.
- W3113163938 hasConceptScore W3113163938C150194340 @default.
- W3113163938 hasConceptScore W3113163938C179926584 @default.
- W3113163938 hasConceptScore W3113163938C197077220 @default.
- W3113163938 hasConceptScore W3113163938C41895202 @default.
- W3113163938 hasConceptScore W3113163938C54355233 @default.
- W3113163938 hasConceptScore W3113163938C62203573 @default.
- W3113163938 hasConceptScore W3113163938C67705224 @default.
- W3113163938 hasConceptScore W3113163938C70721500 @default.
- W3113163938 hasConceptScore W3113163938C83640560 @default.
- W3113163938 hasConceptScore W3113163938C86339819 @default.
- W3113163938 hasConceptScore W3113163938C86803240 @default.
- W3113163938 hasLocation W31131639381 @default.
- W3113163938 hasLocation W31131639382 @default.
- W3113163938 hasOpenAccess W3113163938 @default.
- W3113163938 hasPrimaryLocation W31131639381 @default.
- W3113163938 hasRelatedWork W1950782631 @default.
- W3113163938 hasRelatedWork W1968083284 @default.
- W3113163938 hasRelatedWork W2131930552 @default.
- W3113163938 hasRelatedWork W2144256548 @default.
- W3113163938 hasRelatedWork W2171096629 @default.
- W3113163938 hasRelatedWork W2549332635 @default.
- W3113163938 hasRelatedWork W2594022603 @default.
- W3113163938 hasRelatedWork W2738997784 @default.
- W3113163938 hasRelatedWork W2745030230 @default.
- W3113163938 hasRelatedWork W2952676225 @default.
- W3113163938 isParatext "false" @default.
- W3113163938 isRetracted "false" @default.
- W3113163938 magId "3113163938" @default.
- W3113163938 workType "article" @default.