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- W3113165963 abstract "Sacubitril/valsartan is a fixed dose combination of a neprilysin inhibitor (sacubitril) and an AT1 receptor blocker (valsartan), referred to as an angiotensin receptor-neprilysin inhibitor (ARNi). Its indication is in the treatment of heart failure with reduced ejection fraction (HFrEF).1 Hyponatraemia has only been reported once2 as an adverse drug reaction. We here contribute what we believe is the first reported case of ARNi induced chronic asymptomatic severe hyponatraemia, discovered incidentally by routine laboratory testing.A middle-aged woman with a medical history of Cushing’s syndrome, myocardial infarction (MI), Graves’ disease and HFrEF (secondary to previous MI, ejection fraction originally=29%, now 45% after medical therapy) was discovered to have severe …" @default.
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- W3113165963 date "2020-12-11" @default.
- W3113165963 modified "2023-10-16" @default.
- W3113165963 title "Chronic asymptomatic hyponatraemia following angiotensin receptor blocker-neprilysin inhibitor (ARNi) therapy: a case report" @default.
- W3113165963 cites W2028115191 @default.
- W3113165963 cites W2062212141 @default.
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- W3113165963 doi "https://doi.org/10.1136/postgradmedj-2020-139284" @default.
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