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- W3113168527 abstract "Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia. Objective : to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED. Patients and methods . The investigation enrolled 12 patients (4 men and 8 women) aged 21 to 49 years with drug-resistant epilepsy treated with several AEDs, who had initiated therapy with PER as an additional AED. PSG study and questioning survey were done before and 1 month after initiation of PER therapy. Results and discussion . After one month of PER therapy, there was an increase in the quality of night sleep in 5 cases and a reduction in daytime sleepiness in 6 cases. The PSG pattern was stable in 3 patients, worsened in 1, and improved in 8. Conclusion . The preliminary results suggest that PER therapy improves night sleep quality and reduces daytime sleepiness in about half of the cases, as evidenced by the improved PSG pattern in 67% of patients." @default.
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- W3113168527 date "2020-12-12" @default.
- W3113168527 modified "2023-10-03" @default.
- W3113168527 title "The use of perampanel in drug-resistant focal epilepsy: its effect on sleep" @default.
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- W3113168527 doi "https://doi.org/10.14412/2074-2711-2020-6-49-53" @default.
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