FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113177716> ?p ?o ?g. }

• W3113177716 endingPage "118893" @default.
• W3113177716 startingPage "118893" @default.
• W3113177716 abstract "In recent decades, the role of microRNAs (miRNAs) in human diseases has been widely studied. This research is designed to explore the effect of miR-218-5p on knee osteoarthritis (KOA) progression in a rat model with the involvement of sclerostin (SOST).The KOA rat models were constructed by Hulth method, and then were classified into the KOA, miR-218-5p inhibitor, inhibitor negative control (NC), overexpressed (OE)-SOST, OE-NC, miR-218-5p inhibitor + si-SOST, or miR-218-5p inhibitor + si-NC group. The pathological changes of rats' synovial tissues were observed; the apoptosis in rat synovial tissues was assessed; levels of IL-1β, TNF-α, PGE2 and COX-2 in serum and synovial tissues, along with SOD and MDA contents in synovial tissues were determined. The morphological changes in cartilage tissues were observed. MMP-13 and Col II expression in cartilage tissues was assessed; expression of β-catenin and Col2A1 in cartilage tissues was assessed. miR-218-5p and SOST expression in rat knee joint tissues was assessed.KOA rats had increased miR-218-5p expression and decreased SOST expression. MiR-218-5p targeted SOST. Rats injected with miR-218-5p inhibitor and OE-SOST had alleviated pathological changes, reduced TUNEL positive cell rate, decreased serum contents of IL-1β, TNF-α, PGE2, COX-2 and MDA, and increased SOD activity in synovial tissues, alleviated pathological changes, enhanced Col II positive rate and reduced MMP-13 positive rate, decreased β-catenin expression and increased Col2A1 expression in cartilage tissues.The miR-218-5p inhibition could attenuate synovial inflammation and cartilage injury in KOA rats by promoting SOST, which may be helpful for KOA treatment." @default.
• W3113177716 created "2020-12-21" @default.
• W3113177716 creator A5022425976 @default.
• W3113177716 creator A5070857269 @default.
• W3113177716 creator A5072964111 @default.
• W3113177716 creator A5083862643 @default.
• W3113177716 creator A5085596965 @default.
• W3113177716 creator A5089392461 @default.
• W3113177716 date "2021-02-01" @default.
• W3113177716 modified "2023-09-27" @default.
• W3113177716 title "RETRACTED: Inhibited microRNA-218-5p attenuates synovial inflammation and cartilage injury in rats with knee osteoarthritis by promoting sclerostin" @default.
• W3113177716 cites W1976976326 @default.
• W3113177716 cites W2093625328 @default.
• W3113177716 cites W2118529444 @default.
• W3113177716 cites W2131147498 @default.
• W3113177716 cites W2133584350 @default.
• W3113177716 cites W2259310940 @default.
• W3113177716 cites W2376677157 @default.
• W3113177716 cites W2398761323 @default.
• W3113177716 cites W2530097337 @default.
• W3113177716 cites W2583916613 @default.
• W3113177716 cites W2612159742 @default.
• W3113177716 cites W2748685928 @default.
• W3113177716 cites W2751691420 @default.
• W3113177716 cites W2774530388 @default.
• W3113177716 cites W2775389537 @default.
• W3113177716 cites W2785956848 @default.
• W3113177716 cites W2790451854 @default.
• W3113177716 cites W2792116008 @default.
• W3113177716 cites W2806338288 @default.
• W3113177716 cites W2895598841 @default.
• W3113177716 cites W2922060164 @default.
• W3113177716 cites W2947957415 @default.
• W3113177716 cites W2965454244 @default.
• W3113177716 cites W2977673938 @default.
• W3113177716 doi "https://doi.org/10.1016/j.lfs.2020.118893" @default.
• W3113177716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33316267" @default.
• W3113177716 hasPublicationYear "2021" @default.
• W3113177716 type Work @default.
• W3113177716 sameAs 3113177716 @default.
• W3113177716 citedByCount "8" @default.
• W3113177716 countsByYear W31131777162021 @default.
• W3113177716 countsByYear W31131777162022 @default.
• W3113177716 countsByYear W31131777162023 @default.
• W3113177716 crossrefType "journal-article" @default.
• W3113177716 hasAuthorship W3113177716A5022425976 @default.
• W3113177716 hasAuthorship W3113177716A5070857269 @default.
• W3113177716 hasAuthorship W3113177716A5072964111 @default.
• W3113177716 hasAuthorship W3113177716A5083862643 @default.
• W3113177716 hasAuthorship W3113177716A5085596965 @default.
• W3113177716 hasAuthorship W3113177716A5089392461 @default.
• W3113177716 hasConcept C104317684 @default.
• W3113177716 hasConcept C105702510 @default.
• W3113177716 hasConcept C109523444 @default.
• W3113177716 hasConcept C126322002 @default.
• W3113177716 hasConcept C134018914 @default.
• W3113177716 hasConcept C137620995 @default.
• W3113177716 hasConcept C142724271 @default.
• W3113177716 hasConcept C145059251 @default.
• W3113177716 hasConcept C185592680 @default.
• W3113177716 hasConcept C190283241 @default.
• W3113177716 hasConcept C204787440 @default.
• W3113177716 hasConcept C207886595 @default.
• W3113177716 hasConcept C2776164576 @default.
• W3113177716 hasConcept C2776914184 @default.
• W3113177716 hasConcept C2779277721 @default.
• W3113177716 hasConcept C2780550940 @default.
• W3113177716 hasConcept C2781403057 @default.
• W3113177716 hasConcept C502942594 @default.
• W3113177716 hasConcept C55493867 @default.
• W3113177716 hasConcept C62478195 @default.
• W3113177716 hasConcept C71924100 @default.
• W3113177716 hasConceptScore W3113177716C104317684 @default.
• W3113177716 hasConceptScore W3113177716C105702510 @default.
• W3113177716 hasConceptScore W3113177716C109523444 @default.
• W3113177716 hasConceptScore W3113177716C126322002 @default.
• W3113177716 hasConceptScore W3113177716C134018914 @default.
• W3113177716 hasConceptScore W3113177716C137620995 @default.
• W3113177716 hasConceptScore W3113177716C142724271 @default.
• W3113177716 hasConceptScore W3113177716C145059251 @default.
• W3113177716 hasConceptScore W3113177716C185592680 @default.
• W3113177716 hasConceptScore W3113177716C190283241 @default.
• W3113177716 hasConceptScore W3113177716C204787440 @default.
• W3113177716 hasConceptScore W3113177716C207886595 @default.
• W3113177716 hasConceptScore W3113177716C2776164576 @default.
• W3113177716 hasConceptScore W3113177716C2776914184 @default.
• W3113177716 hasConceptScore W3113177716C2779277721 @default.
• W3113177716 hasConceptScore W3113177716C2780550940 @default.
• W3113177716 hasConceptScore W3113177716C2781403057 @default.
• W3113177716 hasConceptScore W3113177716C502942594 @default.
• W3113177716 hasConceptScore W3113177716C55493867 @default.
• W3113177716 hasConceptScore W3113177716C62478195 @default.
• W3113177716 hasConceptScore W3113177716C71924100 @default.
• W3113177716 hasLocation W31131777161 @default.
• W3113177716 hasLocation W31131777162 @default.
• W3113177716 hasOpenAccess W3113177716 @default.
• W3113177716 hasPrimaryLocation W31131777161 @default.
• W3113177716 hasRelatedWork W2033329636 @default.

• next