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- W3113183766 abstract "Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate CEs to some pesticides, pharmaceuticals, personal care products and plastic additives to assess their potential interaction on this enzymatic system and its suitability as biomarkers. Three bivalves, one gastropod and two crustaceans were used and CEs were quantified following current protocols set for mammalian models. Four substrates were screened for CEs determination and to test their adequacy in the hepatic fraction measures of the selected invertebrates. Two commercial recombinant human isoforms (hCE1 and hCE2) were also included for methodological validation. Among the invertebrates, mussels were revealed as the most sensitive to xenobiotic exposures while gastropods were the least as well as with particular substrate-specific preferences. Among chemicals of environmental concern, the plastic additive tetrabromobisphenol A displayed the highest CE-inhibitory capacity in all species. Since plastic additives easily breakdown from the polymer and may accumulate and metabolise in marine biota, their interaction with the CE key metabolic/detoxification processes may have consequences in invertebrate’s physiology, affect bioaccumulation and therefore trophic web transfer and, ultimately, human health as shellfish consumers." @default.
- W3113183766 created "2020-12-21" @default.
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- W3113183766 date "2021-02-01" @default.
- W3113183766 modified "2023-10-17" @default.
- W3113183766 title "The use of an in vitro approach to assess marine invertebrate carboxylesterase responses to chemicals of environmental concern" @default.
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- W3113183766 doi "https://doi.org/10.1016/j.etap.2020.103561" @default.
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