Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113187519> ?p ?o ?g. }
- W3113187519 abstract "Abstract Objectives The decidua is a tissue that contacts both maternal and foetal components and is pivotal to labour onset due to its location. Due to the heterogeneity of decidual tissue, it is challenging to study its role in the peripartum period. Herein, we analysed the transcriptomes of peripartum decidua at single‐cell resolution. Materials and methods Single‐cell RNA sequencing was performed for 29 231 decidual cells before and after delivery to characterize the transcriptomes. Results Eight major cell types (including endothelial cells, fibroblasts) and subtypes of decidual stromal cells, extravillous trophoblasts and T cells were identified and found to have various functions. Compared with before delivery, the activation of decidual stromal cell, extravillous trophoblast and T‐cell subtypes to different degrees was observed after delivery. Furthermore, the activation involved multiple functions, such as cell proliferation, and several pathways, such as the activator protein 1 pathway. The results of pseudotemporal ordering showed differentiation of decidual stromal cell and extravillous trophoblast subtypes, suggesting inhomogeneity of these subgroups in decidualization (decidual stromal cell) and invasion (extravillous trophoblast). Conclusions The peripartum decidual tissue is heterogeneous. This study revealed changes in the decidua and its components at single‐cell resolution; these findings provide a new perspective for the study of peripartum decidua." @default.
- W3113187519 created "2020-12-21" @default.
- W3113187519 creator A5002082362 @default.
- W3113187519 creator A5006300765 @default.
- W3113187519 creator A5018636031 @default.
- W3113187519 creator A5020275396 @default.
- W3113187519 creator A5020746135 @default.
- W3113187519 creator A5025396130 @default.
- W3113187519 creator A5029513083 @default.
- W3113187519 creator A5040789343 @default.
- W3113187519 creator A5065831014 @default.
- W3113187519 creator A5067038209 @default.
- W3113187519 creator A5068793970 @default.
- W3113187519 creator A5074877144 @default.
- W3113187519 creator A5076945174 @default.
- W3113187519 creator A5090931194 @default.
- W3113187519 creator A5090950891 @default.
- W3113187519 creator A5091456544 @default.
- W3113187519 date "2020-12-09" @default.
- W3113187519 modified "2023-10-12" @default.
- W3113187519 title "Single‐cell RNA sequencing reveals heterogeneity and differential expression of decidual tissues during the peripartum period" @default.
- W3113187519 cites W1533471141 @default.
- W3113187519 cites W1957127190 @default.
- W3113187519 cites W1963915233 @default.
- W3113187519 cites W1966540228 @default.
- W3113187519 cites W1975322285 @default.
- W3113187519 cites W1986223776 @default.
- W3113187519 cites W2004670706 @default.
- W3113187519 cites W2010101647 @default.
- W3113187519 cites W2010321952 @default.
- W3113187519 cites W2071476107 @default.
- W3113187519 cites W2078493611 @default.
- W3113187519 cites W2101855342 @default.
- W3113187519 cites W2111436522 @default.
- W3113187519 cites W2152228425 @default.
- W3113187519 cites W2158774684 @default.
- W3113187519 cites W2340310656 @default.
- W3113187519 cites W2555465097 @default.
- W3113187519 cites W2566793662 @default.
- W3113187519 cites W2586513851 @default.
- W3113187519 cites W2586681801 @default.
- W3113187519 cites W2589572904 @default.
- W3113187519 cites W2616554934 @default.
- W3113187519 cites W2726854110 @default.
- W3113187519 cites W2741756656 @default.
- W3113187519 cites W2747599801 @default.
- W3113187519 cites W2749281307 @default.
- W3113187519 cites W2789716091 @default.
- W3113187519 cites W2801499275 @default.
- W3113187519 cites W2809667147 @default.
- W3113187519 cites W2883778176 @default.
- W3113187519 cites W2887396627 @default.
- W3113187519 cites W2895456557 @default.
- W3113187519 cites W2896518632 @default.
- W3113187519 cites W2898759023 @default.
- W3113187519 cites W2900144939 @default.
- W3113187519 cites W2903489697 @default.
- W3113187519 cites W2911502125 @default.
- W3113187519 cites W2920186621 @default.
- W3113187519 cites W2921569747 @default.
- W3113187519 cites W2923527868 @default.
- W3113187519 cites W2928665623 @default.
- W3113187519 cites W2944572852 @default.
- W3113187519 cites W2946289631 @default.
- W3113187519 cites W2946979874 @default.
- W3113187519 cites W2955720280 @default.
- W3113187519 cites W2973209947 @default.
- W3113187519 cites W3014836949 @default.
- W3113187519 cites W3080771457 @default.
- W3113187519 doi "https://doi.org/10.1111/cpr.12967" @default.
- W3113187519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7848970" @default.
- W3113187519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33300223" @default.
- W3113187519 hasPublicationYear "2020" @default.
- W3113187519 type Work @default.
- W3113187519 sameAs 3113187519 @default.
- W3113187519 citedByCount "16" @default.
- W3113187519 countsByYear W31131875192021 @default.
- W3113187519 countsByYear W31131875192022 @default.
- W3113187519 countsByYear W31131875192023 @default.
- W3113187519 crossrefType "journal-article" @default.
- W3113187519 hasAuthorship W3113187519A5002082362 @default.
- W3113187519 hasAuthorship W3113187519A5006300765 @default.
- W3113187519 hasAuthorship W3113187519A5018636031 @default.
- W3113187519 hasAuthorship W3113187519A5020275396 @default.
- W3113187519 hasAuthorship W3113187519A5020746135 @default.
- W3113187519 hasAuthorship W3113187519A5025396130 @default.
- W3113187519 hasAuthorship W3113187519A5029513083 @default.
- W3113187519 hasAuthorship W3113187519A5040789343 @default.
- W3113187519 hasAuthorship W3113187519A5065831014 @default.
- W3113187519 hasAuthorship W3113187519A5067038209 @default.
- W3113187519 hasAuthorship W3113187519A5068793970 @default.
- W3113187519 hasAuthorship W3113187519A5074877144 @default.
- W3113187519 hasAuthorship W3113187519A5076945174 @default.
- W3113187519 hasAuthorship W3113187519A5090931194 @default.
- W3113187519 hasAuthorship W3113187519A5090950891 @default.
- W3113187519 hasAuthorship W3113187519A5091456544 @default.
- W3113187519 hasBestOaLocation W31131875191 @default.
- W3113187519 hasConcept C1491633281 @default.
- W3113187519 hasConcept C16685009 @default.
- W3113187519 hasConcept C16930146 @default.