FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113188540> ?p ?o ?g. }

• W3113188540 endingPage "256" @default.
• W3113188540 startingPage "247" @default.
• W3113188540 abstract "Background Quantitative skeletal muscle mass loss has the potential to predict the therapeutic effects of immune checkpoint inhibitors. This study aimed to assess the impact of muscular quality on the abovementioned outcomes. Methods This study retrospectively reviewed the medical records of patients with advanced non-small cell lung cancer (NSCLC) who had received PD-1/PD-L1 inhibitor monotherapy between March 2016 and February 2018. High muscle quality was stipulated as a skeletal muscle density ≥41 and ≥33 Hounsfield units in patients with a body mass index (BMI) <25 kg/m2 and ≥25 kg/m2, respectively, as assessed using lumbar computed tomography images. High muscle quantity was stipulated as a lumbar skeletal muscle index ≥41 cm2/m2 in women, ≥43 cm2/m2 in men with a BMI <25 kg/m2, and ≥53 cm2/m2 in men with a BMI ≥25 kg/m2. We evaluated the associations of these muscular parameters with the overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Results Out of 156 patients, 80 (51.3%) and 47 (30.1%) showed low muscle quality and quantity, respectively. Patients with high muscle quality showed higher ORR (35.0 vs. 15.8 %, p<0.05) and longer PFS durations (median, 4.5 vs. 2.0 months, p<0.05) than those with low muscle quality. There were no noted differences in the ORR or PFS between patients with high and those with low muscle quantities. On the contrary, regardless of muscle quality and quantity, there were no differences in OS between patients with high and those with low muscle status. Conclusions Lumbar skeletal muscle quality has the potential to predict the therapeutic effect of anti-programed cell death 1/programed cell death ligand 1 inhibitor monotherapy in patients with advanced NSCLC." @default.
• W3113188540 created "2020-12-21" @default.
• W3113188540 creator A5006451153 @default.
• W3113188540 creator A5012542775 @default.
• W3113188540 creator A5015604127 @default.
• W3113188540 creator A5017887067 @default.
• W3113188540 creator A5020448557 @default.
• W3113188540 creator A5025707585 @default.
• W3113188540 creator A5027913544 @default.
• W3113188540 creator A5035288034 @default.
• W3113188540 creator A5035882975 @default.
• W3113188540 creator A5042715287 @default.
• W3113188540 creator A5052775128 @default.
• W3113188540 creator A5057467373 @default.
• W3113188540 creator A5064708494 @default.
• W3113188540 creator A5067386004 @default.
• W3113188540 creator A5078077911 @default.
• W3113188540 creator A5090583909 @default.
• W3113188540 date "2020-12-10" @default.
• W3113188540 modified "2023-09-27" @default.
• W3113188540 title "Unfavorable impact of decreased muscle quality on the efficacy of immunotherapy for advanced non‐small cell lung cancer" @default.
• W3113188540 cites W1889335134 @default.
• W3113188540 cites W1919200564 @default.
• W3113188540 cites W2011627030 @default.
• W3113188540 cites W2039434272 @default.
• W3113188540 cites W2103784531 @default.
• W3113188540 cites W2118558111 @default.
• W3113188540 cites W2121960517 @default.
• W3113188540 cites W2145280166 @default.
• W3113188540 cites W2228221433 @default.
• W3113188540 cites W2234490399 @default.
• W3113188540 cites W2312518973 @default.
• W3113188540 cites W2535300095 @default.
• W3113188540 cites W2547310148 @default.
• W3113188540 cites W2553667461 @default.
• W3113188540 cites W2563204578 @default.
• W3113188540 cites W2581283430 @default.
• W3113188540 cites W2737656823 @default.
• W3113188540 cites W2765326687 @default.
• W3113188540 cites W2779658193 @default.
• W3113188540 cites W2790804169 @default.
• W3113188540 cites W2806614796 @default.
• W3113188540 cites W2809550395 @default.
• W3113188540 cites W2888502795 @default.
• W3113188540 cites W2897924763 @default.
• W3113188540 cites W2903848939 @default.
• W3113188540 cites W2907585801 @default.
• W3113188540 cites W2910245285 @default.
• W3113188540 cites W2919778409 @default.
• W3113188540 cites W2925446385 @default.
• W3113188540 cites W2933875892 @default.
• W3113188540 cites W2946663348 @default.
• W3113188540 cites W2947830489 @default.
• W3113188540 cites W2949515538 @default.
• W3113188540 cites W2953106870 @default.
• W3113188540 cites W2971778236 @default.
• W3113188540 cites W2995498417 @default.
• W3113188540 cites W3003196240 @default.
• W3113188540 cites W3003678311 @default.
• W3113188540 cites W3005951584 @default.
• W3113188540 doi "https://doi.org/10.1002/cam4.3631" @default.
• W3113188540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7826480" @default.
• W3113188540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33300678" @default.
• W3113188540 hasPublicationYear "2020" @default.
• W3113188540 type Work @default.
• W3113188540 sameAs 3113188540 @default.
• W3113188540 citedByCount "17" @default.
• W3113188540 countsByYear W31131885402021 @default.
• W3113188540 countsByYear W31131885402022 @default.
• W3113188540 countsByYear W31131885402023 @default.
• W3113188540 crossrefType "journal-article" @default.
• W3113188540 hasAuthorship W3113188540A5006451153 @default.
• W3113188540 hasAuthorship W3113188540A5012542775 @default.
• W3113188540 hasAuthorship W3113188540A5015604127 @default.
• W3113188540 hasAuthorship W3113188540A5017887067 @default.
• W3113188540 hasAuthorship W3113188540A5020448557 @default.
• W3113188540 hasAuthorship W3113188540A5025707585 @default.
• W3113188540 hasAuthorship W3113188540A5027913544 @default.
• W3113188540 hasAuthorship W3113188540A5035288034 @default.
• W3113188540 hasAuthorship W3113188540A5035882975 @default.
• W3113188540 hasAuthorship W3113188540A5042715287 @default.
• W3113188540 hasAuthorship W3113188540A5052775128 @default.
• W3113188540 hasAuthorship W3113188540A5057467373 @default.
• W3113188540 hasAuthorship W3113188540A5064708494 @default.
• W3113188540 hasAuthorship W3113188540A5067386004 @default.
• W3113188540 hasAuthorship W3113188540A5078077911 @default.
• W3113188540 hasAuthorship W3113188540A5090583909 @default.
• W3113188540 hasBestOaLocation W31131885402 @default.
• W3113188540 hasConcept C121608353 @default.
• W3113188540 hasConcept C126322002 @default.
• W3113188540 hasConcept C126894567 @default.
• W3113188540 hasConcept C141071460 @default.
• W3113188540 hasConcept C143998085 @default.
• W3113188540 hasConcept C187954543 @default.
• W3113188540 hasConcept C2776256026 @default.
• W3113188540 hasConcept C2779959927 @default.
• W3113188540 hasConcept C2780221984 @default.
• W3113188540 hasConcept C544519230 @default.

• next