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- W3113189722 abstract "Abstract Background To investigate the effect of onset‐age on the baseline and longitudinal changes in A/T/N imaging biomarkers in the Alzheimer’s disease (AD) spectrum. Method 71 Aβ‐positive cognitively impaired (CI+) individuals and 67 Aβ‐negative cognitively unimpaired (CU‐) individuals completed longitudinal two PET scans ( 18 F‐florbetaben for Aβ and 18 F‐flortaucipir for tau) and magnetic resonance (MR) imaging studies with a mean follow‐up duration of two years. Based on the onset‐age of cognitive impairment, baseline and the annual change in standardized uptake value ratio (SUVR) values and regional volumes were compared between 15 early‐onset (EOCI+, onset < 65 yrs) and 56 late‐onset (LOCI+, onset ≥ 65 yrs) CI+ groups. Result Baseline Aβ burden and its accumulation rate were not different between the EOCI+ and LOCI+ groups. When compared to LOCI+, EOCI+ group showed greater baseline tau burden and its accumulation rate in widespread cortical regions except for the medial temporal regions. Baseline volume of the entorhinal cortex was smaller in the LOCI+ group than that in the EOCI+ group, while the volume atrophy rates in the parietal cortex and precuneus were higher in the EOCI+ group although these regions did not survive correcting for region‐wise multiple comparisons. Conclusion Early‐onset AD patients have greater tau burden and are more likely to be vulnerable to progressive tau accumulation in the widespread neocortex, and thereby may be more vulnerable to the progressive neurodegeneration than the late‐onset AD." @default.
- W3113189722 created "2020-12-21" @default.
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- W3113189722 date "2020-12-01" @default.
- W3113189722 modified "2023-09-26" @default.
- W3113189722 title "Longitudinal changes in A/T/N imaging biomarkers in early‐onset and late‐onset Alzheimer’s disease" @default.
- W3113189722 doi "https://doi.org/10.1002/alz.046718" @default.
- W3113189722 hasPublicationYear "2020" @default.
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