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- W3113197893 abstract "Arsenic is a toxic heavy metal vastly dispersed all over the earth crust. It manifests several major adverse health issues to millions of arsenic exposed populations. Arsenic is associated with different types of cancer, cardiovascular disorders, diabetes, hypertension and many other diseases. On the contrary, arsenic (arsenic trioxide, As2O3) is used as a chemotherapeutic agent in the treatment of acute promyelocytic leukemia. Balance between arsenic induced cellular proliferations and apoptosis finally decide the outcome of its transformation rate. Arsenic propagates signals via cellular and nuclear pathways depending upon the chemical nature, and metabolic-fates of the arsenical compounds. Arsenic toxicity is propagated via ROS induced stress to DNA-repair mechanism and mitochondrial stability in the cell. ROS induced alteration in p53 regulation and some mitogen/ oncogenic functions determine the transformation outcome influencing cyclin-cdk complexes. Growth factor regulator proteins such as c-Jun, c-fos and c-myc are influenced by chronic arsenic exposure. In this review we have delineated arsenic induced ROS regulations of epidermal growth factor receptor (EGFR), NF-ĸβ, MAP kinase, matrix-metalloproteinases (MMPs). The role of these signaling molecules has been discussed in relation to cellular apoptosis, cellular proliferation and neoplastic transformation. The arsenic stimulated pathways which help in proliferation and neoplastic transformation ultimately resulted in cancer manifestation whereas apoptotic pathways inhibited carcinogenesis. Therapeutic strategies against arsenic should be designed taking into account all these factors." @default.
- W3113197893 created "2020-12-21" @default.
- W3113197893 creator A5018239220 @default.
- W3113197893 creator A5065900520 @default.
- W3113197893 creator A5078430868 @default.
- W3113197893 date "2021-01-01" @default.
- W3113197893 modified "2023-10-14" @default.
- W3113197893 title "Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation" @default.
- W3113197893 cites W1589372977 @default.
- W3113197893 cites W1875328973 @default.
- W3113197893 cites W1964719993 @default.
- W3113197893 cites W1966973738 @default.
- W3113197893 cites W1967415817 @default.
- W3113197893 cites W1968145127 @default.
- W3113197893 cites W1971470223 @default.
- W3113197893 cites W1973769612 @default.
- W3113197893 cites W1973875276 @default.
- W3113197893 cites W1977896790 @default.
- W3113197893 cites W1982353442 @default.
- W3113197893 cites W1983243403 @default.
- W3113197893 cites W1984399156 @default.
- W3113197893 cites W1986884128 @default.
- W3113197893 cites W1989954602 @default.
- W3113197893 cites W1991701837 @default.
- W3113197893 cites W2000612164 @default.
- W3113197893 cites W2007996640 @default.
- W3113197893 cites W2010077871 @default.
- W3113197893 cites W2015471917 @default.
- W3113197893 cites W2016574982 @default.
- W3113197893 cites W2025432140 @default.
- W3113197893 cites W2025571426 @default.
- W3113197893 cites W2030185879 @default.
- W3113197893 cites W2031837180 @default.
- W3113197893 cites W2034269086 @default.
- W3113197893 cites W2035155575 @default.
- W3113197893 cites W2046210218 @default.
- W3113197893 cites W2050375130 @default.
- W3113197893 cites W2050751060 @default.
- W3113197893 cites W2050834307 @default.
- W3113197893 cites W2052082676 @default.
- W3113197893 cites W2053485263 @default.
- W3113197893 cites W2055196302 @default.
- W3113197893 cites W2057200339 @default.
- W3113197893 cites W2058459130 @default.
- W3113197893 cites W2059378857 @default.
- W3113197893 cites W2059999514 @default.
- W3113197893 cites W2061728585 @default.
- W3113197893 cites W2076932702 @default.
- W3113197893 cites W2079465982 @default.
- W3113197893 cites W2080677621 @default.
- W3113197893 cites W2084020509 @default.
- W3113197893 cites W2092088257 @default.
- W3113197893 cites W2101354010 @default.
- W3113197893 cites W2104718696 @default.
- W3113197893 cites W2107462675 @default.
- W3113197893 cites W2108386140 @default.
- W3113197893 cites W2111693820 @default.
- W3113197893 cites W2112908115 @default.
- W3113197893 cites W2115663260 @default.
- W3113197893 cites W2115865903 @default.
- W3113197893 cites W2121040393 @default.
- W3113197893 cites W2122308593 @default.
- W3113197893 cites W2125619234 @default.
- W3113197893 cites W2128923672 @default.
- W3113197893 cites W2129726289 @default.
- W3113197893 cites W2130066440 @default.
- W3113197893 cites W2132448632 @default.
- W3113197893 cites W2134238156 @default.
- W3113197893 cites W2136942407 @default.
- W3113197893 cites W2138047541 @default.
- W3113197893 cites W2145919725 @default.
- W3113197893 cites W2147924866 @default.
- W3113197893 cites W2150076336 @default.
- W3113197893 cites W2150496093 @default.
- W3113197893 cites W2157117401 @default.
- W3113197893 cites W2161446823 @default.
- W3113197893 cites W2162114270 @default.
- W3113197893 cites W2170710435 @default.
- W3113197893 cites W2172249877 @default.
- W3113197893 cites W2184391500 @default.
- W3113197893 cites W2233350916 @default.
- W3113197893 cites W2605701746 @default.
- W3113197893 cites W2999258450 @default.
- W3113197893 cites W4239718055 @default.
- W3113197893 cites W4243944514 @default.
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- W3113197893 doi "https://doi.org/10.1016/j.ecoenv.2020.111752" @default.
- W3113197893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33396077" @default.
- W3113197893 hasPublicationYear "2021" @default.
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