FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113201635> ?p ?o ?g. }

• W3113201635 endingPage "15" @default.
• W3113201635 startingPage "1" @default.
• W3113201635 abstract "10-Hydroxy-2-decenoic acid (10-HDA), also known as royal jelly acid, has a variety of physiological functions, and recent studies have shown that it also has anticancer effects. However, its anticancer mechanisms have not been clearly defined. In this study, we investigated the underlying mechanisms of 10-HDA in A549 human lung cancer cells. We used Cell Counting Kit-8 assay, scratch wound healing assay, flow cytometry, and western blot analysis to investigate its apoptotic effects and underlying mechanism. Our results showed that 10-HDA inhibited the proliferation of three types of human lung cancer cells and had no significant toxic effects on normal cells. Accompanying reactive oxygen species (ROS), 10-HDA induced A549 cell apoptosis by regulating mitochondrial-associated apoptosis, and caused cell cycle arrest at the G0/G1 phase in a time-dependent manner. Meanwhile, 10-HDA also regulated mitogen-activated protein kinase (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-κB) signaling pathways by increasing the expression levels of phosphorylated c-Jun N-terminal kinase, p-p38, and I-κB, and additionally, by decreasing the expression levels of phosphorylated extracellular signal-regulated kinase, p-STAT3, and NF-κB. These effects were blocked by MAPK inhibitors and N-acetyl-L-cysteine. Furthermore, 10-HDA inhibited cell migration by regulating transforming growth factor beta 1 (TGF-β1), SNAI1, GSK-3β, E-cadherin, N-cadherin, and vimentin. Taken together, the results of this study showed that 10-HDA induced cell cycle arrest and apoptosis in A549 human lung cancer cells through ROS-mediated MAPK, STAT3, NF-κB, and TGF-β1 signaling pathways. Therefore, 10-HDA may be a potential therapy for human lung cancer." @default.
• W3113201635 created "2020-12-21" @default.
• W3113201635 creator A5028637363 @default.
• W3113201635 creator A5037222272 @default.
• W3113201635 creator A5037709424 @default.
• W3113201635 creator A5038699052 @default.
• W3113201635 creator A5039791369 @default.
• W3113201635 creator A5040318802 @default.
• W3113201635 creator A5045215647 @default.
• W3113201635 creator A5049192510 @default.
• W3113201635 creator A5056540270 @default.
• W3113201635 creator A5067374383 @default.
• W3113201635 creator A5071773009 @default.
• W3113201635 date "2020-12-08" @default.
• W3113201635 modified "2023-10-13" @default.
• W3113201635 title "10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-κB, and TGF-β1 Signaling Pathways" @default.
• W3113201635 cites W1581544443 @default.
• W3113201635 cites W1970157299 @default.
• W3113201635 cites W1987690673 @default.
• W3113201635 cites W1996405087 @default.
• W3113201635 cites W2001562768 @default.
• W3113201635 cites W2011057338 @default.
• W3113201635 cites W2013628786 @default.
• W3113201635 cites W2014870971 @default.
• W3113201635 cites W2046366843 @default.
• W3113201635 cites W2048899027 @default.
• W3113201635 cites W2055487597 @default.
• W3113201635 cites W2055900062 @default.
• W3113201635 cites W2067142751 @default.
• W3113201635 cites W2081107312 @default.
• W3113201635 cites W2095720556 @default.
• W3113201635 cites W2102942479 @default.
• W3113201635 cites W2105183445 @default.
• W3113201635 cites W2112713036 @default.
• W3113201635 cites W2122077842 @default.
• W3113201635 cites W2127166176 @default.
• W3113201635 cites W2128837490 @default.
• W3113201635 cites W2158592481 @default.
• W3113201635 cites W2481597189 @default.
• W3113201635 cites W2539266343 @default.
• W3113201635 cites W2607120814 @default.
• W3113201635 cites W2761682525 @default.
• W3113201635 cites W2781608852 @default.
• W3113201635 cites W2801326868 @default.
• W3113201635 cites W2810287710 @default.
• W3113201635 cites W2896702258 @default.
• W3113201635 cites W2921621602 @default.
• W3113201635 cites W2924303645 @default.
• W3113201635 cites W2959647110 @default.
• W3113201635 cites W2969292239 @default.
• W3113201635 cites W2972301952 @default.
• W3113201635 cites W2980251308 @default.
• W3113201635 cites W2984062511 @default.
• W3113201635 cites W2993751816 @default.
• W3113201635 cites W2994677258 @default.
• W3113201635 cites W2994827936 @default.
• W3113201635 cites W2997519067 @default.
• W3113201635 cites W2997851282 @default.
• W3113201635 cites W2998166168 @default.
• W3113201635 cites W2998221009 @default.
• W3113201635 cites W2998295496 @default.
• W3113201635 cites W2998448264 @default.
• W3113201635 doi "https://doi.org/10.1155/2020/3042636" @default.
• W3113201635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7744184" @default.
• W3113201635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33376719" @default.
• W3113201635 hasPublicationYear "2020" @default.
• W3113201635 type Work @default.
• W3113201635 sameAs 3113201635 @default.
• W3113201635 citedByCount "18" @default.
• W3113201635 countsByYear W31132016352021 @default.
• W3113201635 countsByYear W31132016352022 @default.
• W3113201635 countsByYear W31132016352023 @default.
• W3113201635 crossrefType "journal-article" @default.
• W3113201635 hasAuthorship W3113201635A5028637363 @default.
• W3113201635 hasAuthorship W3113201635A5037222272 @default.
• W3113201635 hasAuthorship W3113201635A5037709424 @default.
• W3113201635 hasAuthorship W3113201635A5038699052 @default.
• W3113201635 hasAuthorship W3113201635A5039791369 @default.
• W3113201635 hasAuthorship W3113201635A5040318802 @default.
• W3113201635 hasAuthorship W3113201635A5045215647 @default.
• W3113201635 hasAuthorship W3113201635A5049192510 @default.
• W3113201635 hasAuthorship W3113201635A5056540270 @default.
• W3113201635 hasAuthorship W3113201635A5067374383 @default.
• W3113201635 hasAuthorship W3113201635A5071773009 @default.
• W3113201635 hasBestOaLocation W31132016351 @default.
• W3113201635 hasConcept C153911025 @default.
• W3113201635 hasConcept C184235292 @default.
• W3113201635 hasConcept C185592680 @default.
• W3113201635 hasConcept C190283241 @default.
• W3113201635 hasConcept C29537977 @default.
• W3113201635 hasConcept C502942594 @default.
• W3113201635 hasConcept C51551487 @default.
• W3113201635 hasConcept C55493867 @default.
• W3113201635 hasConcept C57074206 @default.
• W3113201635 hasConcept C62478195 @default.
• W3113201635 hasConcept C81729549 @default.
• W3113201635 hasConcept C86803240 @default.
• W3113201635 hasConcept C95444343 @default.

• next