Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113227612> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3113227612 endingPage "140" @default.
- W3113227612 startingPage "131" @default.
- W3113227612 abstract "Background: Acute myeloid leukemia (AML) is a hematopoietic neoplasm. Tumor suppressors have a magnificent role in preventing the AML process. The absolute lymphocyte count is a simple yet statistically powerful estimate in patients with acute leukemia besides the lymphocyte’s percentage. Aim: Investigating the prognostic value of absolute lymphocyte count, lymphocyte percentage, serum albumin, the aberrant expression of CD7and CD19 and the tumor suppressor genes (PTEN and p53) in patients with AML. Methods: 35 de novo AML patients were included. They received the standard induction chemotherapy (3+7 protocol) and were followed up for one year after treatment. 15 normal healthy individuals, age and sex matched constituted the controls.Results: The mean overall survival of patients with lymphocyte percentage ≤25 was low compared to those with high lymphocyte percentage (>25%) (χ2 =5.808, P=0.016). AML patients with low levels of ALC showed significantly shorter overall survival than patients with high levels (χ2 =4.587, P= 0.032). AML patients with low serum albumin were of low overall survival compared to those with normal level (χ2 =8.698, P=0.003). Patients with aberrant CD7 expression showed short survival and unresponsiveness to treatment than CD7 negative patients. PTEN gene expression and p53 protein level were significantly lower in AML patients compared to the control group.Conclusion: The decrease in ALC, lymphocyte percentage, albumin concentration and the increase in monocyte percentage indicates bad prognosis in AML patients. The Aberrant CD7 expression, very low expression of PTEN and low level of p53 could estimate the unresponsiveness to standard chemotherapy." @default.
- W3113227612 created "2020-12-21" @default.
- W3113227612 creator A5009533847 @default.
- W3113227612 creator A5015983696 @default.
- W3113227612 creator A5020526882 @default.
- W3113227612 creator A5026064746 @default.
- W3113227612 creator A5052727746 @default.
- W3113227612 creator A5053326858 @default.
- W3113227612 creator A5081610683 @default.
- W3113227612 date "2020-12-07" @default.
- W3113227612 modified "2023-09-26" @default.
- W3113227612 title "Prognostic Value of Absolute Lymphocyte count, Lymphocyte percentage, Serum albumin, Aberrant Expression of CD7, CD19 and the Tumor Suppressors (PTEN and p53) in Patients with Acute Myeloid Leukemia" @default.
- W3113227612 doi "https://doi.org/10.31557/apjcb.2020.5.4.131-140" @default.
- W3113227612 hasPublicationYear "2020" @default.
- W3113227612 type Work @default.
- W3113227612 sameAs 3113227612 @default.
- W3113227612 citedByCount "2" @default.
- W3113227612 countsByYear W31132276122021 @default.
- W3113227612 countsByYear W31132276122022 @default.
- W3113227612 crossrefType "journal-article" @default.
- W3113227612 hasAuthorship W3113227612A5009533847 @default.
- W3113227612 hasAuthorship W3113227612A5015983696 @default.
- W3113227612 hasAuthorship W3113227612A5020526882 @default.
- W3113227612 hasAuthorship W3113227612A5026064746 @default.
- W3113227612 hasAuthorship W3113227612A5052727746 @default.
- W3113227612 hasAuthorship W3113227612A5053326858 @default.
- W3113227612 hasAuthorship W3113227612A5081610683 @default.
- W3113227612 hasBestOaLocation W31132276121 @default.
- W3113227612 hasConcept C126322002 @default.
- W3113227612 hasConcept C190283241 @default.
- W3113227612 hasConcept C203014093 @default.
- W3113227612 hasConcept C2776863199 @default.
- W3113227612 hasConcept C2777609662 @default.
- W3113227612 hasConcept C2777761686 @default.
- W3113227612 hasConcept C2778461978 @default.
- W3113227612 hasConcept C2778729363 @default.
- W3113227612 hasConcept C2778957590 @default.
- W3113227612 hasConcept C2779282312 @default.
- W3113227612 hasConcept C55493867 @default.
- W3113227612 hasConcept C71924100 @default.
- W3113227612 hasConcept C86554907 @default.
- W3113227612 hasConcept C86803240 @default.
- W3113227612 hasConcept C8891405 @default.
- W3113227612 hasConcept C90924648 @default.
- W3113227612 hasConceptScore W3113227612C126322002 @default.
- W3113227612 hasConceptScore W3113227612C190283241 @default.
- W3113227612 hasConceptScore W3113227612C203014093 @default.
- W3113227612 hasConceptScore W3113227612C2776863199 @default.
- W3113227612 hasConceptScore W3113227612C2777609662 @default.
- W3113227612 hasConceptScore W3113227612C2777761686 @default.
- W3113227612 hasConceptScore W3113227612C2778461978 @default.
- W3113227612 hasConceptScore W3113227612C2778729363 @default.
- W3113227612 hasConceptScore W3113227612C2778957590 @default.
- W3113227612 hasConceptScore W3113227612C2779282312 @default.
- W3113227612 hasConceptScore W3113227612C55493867 @default.
- W3113227612 hasConceptScore W3113227612C71924100 @default.
- W3113227612 hasConceptScore W3113227612C86554907 @default.
- W3113227612 hasConceptScore W3113227612C86803240 @default.
- W3113227612 hasConceptScore W3113227612C8891405 @default.
- W3113227612 hasConceptScore W3113227612C90924648 @default.
- W3113227612 hasIssue "4" @default.
- W3113227612 hasLocation W31132276121 @default.
- W3113227612 hasOpenAccess W3113227612 @default.
- W3113227612 hasPrimaryLocation W31132276121 @default.
- W3113227612 hasRelatedWork W10263580 @default.
- W3113227612 hasRelatedWork W13741169 @default.
- W3113227612 hasRelatedWork W14553677 @default.
- W3113227612 hasRelatedWork W14902789 @default.
- W3113227612 hasRelatedWork W1605945 @default.
- W3113227612 hasRelatedWork W18341126 @default.
- W3113227612 hasRelatedWork W19100229 @default.
- W3113227612 hasRelatedWork W20551694 @default.
- W3113227612 hasRelatedWork W2466094 @default.
- W3113227612 hasRelatedWork W3438884 @default.
- W3113227612 hasVolume "5" @default.
- W3113227612 isParatext "false" @default.
- W3113227612 isRetracted "false" @default.
- W3113227612 magId "3113227612" @default.
- W3113227612 workType "article" @default.