Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113235093> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3113235093 abstract "Abstract INTRODUCTION Methylguanine methyltransferase (MGMT) methylation status is associated with better overall survival while 1p19q co-deletion is associated with long-term survival. Cognitive dysfunction is a common complication of brain tumors and treatment; however, information regarding the relationship between MGMT status, 1p19q codeletion, and cognition is limited. METHOD Baseline neuropsychological testing was performed in patients with malignant glioma prior to radiation and/or chemotherapy administration. A retrospective data analysis was conducted. We calculated composite and subdomain scores for attention/executive functioning, memory, and language in patients with or without MGMT promotor methylation and/or 1p19q codeletion. RESULTS Thirty-eight patients (Age M = 48.73 ± 14.98; 50% female) diagnosed with glioma (29% grade II, 16% grade III, 21% grade IV; Karnofsky Performance Status score (KPS) M = 88.75 ± 14.24) were selected from a retrospective. Memory was marginally significant, such that methylated participants performed better on memory tasks than the unmethylated group (p = .053). Independent samples t-test revealed no significant differences between either marker across the overall cognitive composite (methylated M = 41.35; unmethylated: M = 39.91; p = .955; 1p19q co-deleted: M = 50.94; 1p19q intact: M = 43.66; p = .158) and subdomains attention/executive functioning (p = .585; p = .157) and language (p = .581; p = .765). Logistic regression showed MGMT does not predict cognitive status (p =.052) and there were not enough cases to complete the model with 1p19q. CONCLUSION MGMT status may be correlated with baseline cognitive status as MGMT methylated patients had better memory scores than their unmethylated counterparts. We did not find any significant association between the remaining cognitive domains and MGMT or 1p19q although sample size is a significant limitation. These results suggest further assessment of changes in cognition during treatment through serial neuropsychological testing of glioma populations with defined marker status is warranted." @default.
- W3113235093 created "2020-12-21" @default.
- W3113235093 creator A5008191765 @default.
- W3113235093 creator A5010216039 @default.
- W3113235093 creator A5013185304 @default.
- W3113235093 creator A5013276544 @default.
- W3113235093 creator A5023144181 @default.
- W3113235093 creator A5030012602 @default.
- W3113235093 creator A5040763051 @default.
- W3113235093 creator A5048781387 @default.
- W3113235093 creator A5053135133 @default.
- W3113235093 creator A5053414244 @default.
- W3113235093 creator A5054135275 @default.
- W3113235093 creator A5056464333 @default.
- W3113235093 creator A5057019702 @default.
- W3113235093 date "2020-11-01" @default.
- W3113235093 modified "2023-09-27" @default.
- W3113235093 title "NCOG-76. BASELINE COGNITIVE ASSESSMENT IN GLIOMA PATIENTS WITH MGMT PROMOTOR METHYLATION AND/OR 1p19q CODELETION" @default.
- W3113235093 doi "https://doi.org/10.1093/neuonc/noaa215.613" @default.
- W3113235093 hasPublicationYear "2020" @default.
- W3113235093 type Work @default.
- W3113235093 sameAs 3113235093 @default.
- W3113235093 citedByCount "0" @default.
- W3113235093 crossrefType "journal-article" @default.
- W3113235093 hasAuthorship W3113235093A5008191765 @default.
- W3113235093 hasAuthorship W3113235093A5010216039 @default.
- W3113235093 hasAuthorship W3113235093A5013185304 @default.
- W3113235093 hasAuthorship W3113235093A5013276544 @default.
- W3113235093 hasAuthorship W3113235093A5023144181 @default.
- W3113235093 hasAuthorship W3113235093A5030012602 @default.
- W3113235093 hasAuthorship W3113235093A5040763051 @default.
- W3113235093 hasAuthorship W3113235093A5048781387 @default.
- W3113235093 hasAuthorship W3113235093A5053135133 @default.
- W3113235093 hasAuthorship W3113235093A5053414244 @default.
- W3113235093 hasAuthorship W3113235093A5054135275 @default.
- W3113235093 hasAuthorship W3113235093A5056464333 @default.
- W3113235093 hasAuthorship W3113235093A5057019702 @default.
- W3113235093 hasBestOaLocation W31132350931 @default.
- W3113235093 hasConcept C104317684 @default.
- W3113235093 hasConcept C118552586 @default.
- W3113235093 hasConcept C126322002 @default.
- W3113235093 hasConcept C14216870 @default.
- W3113235093 hasConcept C143998085 @default.
- W3113235093 hasConcept C151956035 @default.
- W3113235093 hasConcept C167135981 @default.
- W3113235093 hasConcept C169900460 @default.
- W3113235093 hasConcept C185711340 @default.
- W3113235093 hasConcept C2778227246 @default.
- W3113235093 hasConcept C33288867 @default.
- W3113235093 hasConcept C502942594 @default.
- W3113235093 hasConcept C536788834 @default.
- W3113235093 hasConcept C54355233 @default.
- W3113235093 hasConcept C71924100 @default.
- W3113235093 hasConcept C86803240 @default.
- W3113235093 hasConcept C90924648 @default.
- W3113235093 hasConcept C91965660 @default.
- W3113235093 hasConceptScore W3113235093C104317684 @default.
- W3113235093 hasConceptScore W3113235093C118552586 @default.
- W3113235093 hasConceptScore W3113235093C126322002 @default.
- W3113235093 hasConceptScore W3113235093C14216870 @default.
- W3113235093 hasConceptScore W3113235093C143998085 @default.
- W3113235093 hasConceptScore W3113235093C151956035 @default.
- W3113235093 hasConceptScore W3113235093C167135981 @default.
- W3113235093 hasConceptScore W3113235093C169900460 @default.
- W3113235093 hasConceptScore W3113235093C185711340 @default.
- W3113235093 hasConceptScore W3113235093C2778227246 @default.
- W3113235093 hasConceptScore W3113235093C33288867 @default.
- W3113235093 hasConceptScore W3113235093C502942594 @default.
- W3113235093 hasConceptScore W3113235093C536788834 @default.
- W3113235093 hasConceptScore W3113235093C54355233 @default.
- W3113235093 hasConceptScore W3113235093C71924100 @default.
- W3113235093 hasConceptScore W3113235093C86803240 @default.
- W3113235093 hasConceptScore W3113235093C90924648 @default.
- W3113235093 hasConceptScore W3113235093C91965660 @default.
- W3113235093 hasLocation W31132350931 @default.
- W3113235093 hasLocation W31132350932 @default.
- W3113235093 hasLocation W31132350933 @default.
- W3113235093 hasOpenAccess W3113235093 @default.
- W3113235093 hasPrimaryLocation W31132350931 @default.
- W3113235093 hasRelatedWork W12927781 @default.
- W3113235093 hasRelatedWork W13212225 @default.
- W3113235093 hasRelatedWork W16537264 @default.
- W3113235093 hasRelatedWork W16813088 @default.
- W3113235093 hasRelatedWork W17183283 @default.
- W3113235093 hasRelatedWork W518170 @default.
- W3113235093 hasRelatedWork W5652776 @default.
- W3113235093 hasRelatedWork W6858922 @default.
- W3113235093 hasRelatedWork W7345259 @default.
- W3113235093 hasRelatedWork W7864341 @default.
- W3113235093 isParatext "false" @default.
- W3113235093 isRetracted "false" @default.
- W3113235093 magId "3113235093" @default.
- W3113235093 workType "article" @default.