FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113246253> ?p ?o ?g. }

• W3113246253 endingPage "1665" @default.
• W3113246253 startingPage "1649" @default.
• W3113246253 abstract "The aim of this study is to investigate the gene expression module of tumor-infiltrating CD4+T cells and its potential roles in modulating immune cell functions in triple-negative breast cancer. Differentially expressed genes were identified by comparison of the expression profile in CD4+T cells isolated from tumor tissues and peripheral blood of TNBC patients respectively. The differential expression analysis was conducted using R, and then the functional and pathway enrichment of the DEGs were analyzed using GSEA, followed by integrated regulatory network construction and genetic analysis of tumor-infiltrating immune cells based on a scientific deconvolution algorithm. As a result, abundant Treg and exhausted lymphocytes were detected, accompanied by largely decreased of effector/memory and cytotoxic T cells. Immune-related gene correlation analysis showed that the extent of follicular helper T cells gene expression signatures were inversely associated with those of CD4+ naive T cells and CD4+ memory resting T cells, but positively correlated with that of CD4+ memory activated T cells. In addition, we found five core genes including IFNG, CTLA4, FAS, CXCR6, and JUN were significantly over expressed in CD4+ TILs which may contribute to exhaustion of lymphocytes and participate in biological processes associated with regulation of chemotaxis. Study provides a comprehensive understanding of the roles of DEGs associated with the chemotactic and exhausted immunophenotypes of CD4+ TILs that are a valuable resource from which future investigation may be carried out to better understand the mechanisms that promote TNBC progression." @default.
• W3113246253 created "2020-12-21" @default.
• W3113246253 creator A5004341112 @default.
• W3113246253 creator A5029671704 @default.
• W3113246253 creator A5050999545 @default.
• W3113246253 creator A5064323494 @default.
• W3113246253 creator A5077503025 @default.
• W3113246253 date "2020-12-10" @default.
• W3113246253 modified "2023-10-02" @default.
• W3113246253 title "Comprehensive genomic and immunophenotypic analysis of CD4 T cell infiltrating human triple-negative breast cancer" @default.
• W3113246253 cites W1660417362 @default.
• W3113246253 cites W1925268733 @default.
• W3113246253 cites W1954790852 @default.
• W3113246253 cites W1967937330 @default.
• W3113246253 cites W1968564472 @default.
• W3113246253 cites W1985987855 @default.
• W3113246253 cites W2006683252 @default.
• W3113246253 cites W2007026865 @default.
• W3113246253 cites W2032831781 @default.
• W3113246253 cites W2064982197 @default.
• W3113246253 cites W2066788310 @default.
• W3113246253 cites W2071793654 @default.
• W3113246253 cites W2096173332 @default.
• W3113246253 cites W2103912979 @default.
• W3113246253 cites W2108819945 @default.
• W3113246253 cites W2116634113 @default.
• W3113246253 cites W2121099202 @default.
• W3113246253 cites W2123521672 @default.
• W3113246253 cites W2127401224 @default.
• W3113246253 cites W2130410032 @default.
• W3113246253 cites W2138753037 @default.
• W3113246253 cites W2151709200 @default.
• W3113246253 cites W2152431559 @default.
• W3113246253 cites W2158217645 @default.
• W3113246253 cites W2159675211 @default.
• W3113246253 cites W2160117150 @default.
• W3113246253 cites W2160195286 @default.
• W3113246253 cites W2170989872 @default.
• W3113246253 cites W2178133357 @default.
• W3113246253 cites W2294216513 @default.
• W3113246253 cites W2340735966 @default.
• W3113246253 cites W2365243214 @default.
• W3113246253 cites W2560367415 @default.
• W3113246253 cites W2586349900 @default.
• W3113246253 cites W2757666766 @default.
• W3113246253 cites W2767960065 @default.
• W3113246253 cites W2792021646 @default.
• W3113246253 cites W2799464107 @default.
• W3113246253 cites W2896635050 @default.
• W3113246253 cites W2902690248 @default.
• W3113246253 cites W2902858460 @default.
• W3113246253 cites W2908418483 @default.
• W3113246253 cites W2911757002 @default.
• W3113246253 cites W2940666965 @default.
• W3113246253 cites W2943226078 @default.
• W3113246253 cites W2947691713 @default.
• W3113246253 cites W2948835056 @default.
• W3113246253 cites W2968063051 @default.
• W3113246253 cites W2969823614 @default.
• W3113246253 cites W2971302797 @default.
• W3113246253 cites W2984186351 @default.
• W3113246253 cites W2986307037 @default.
• W3113246253 cites W2990513257 @default.
• W3113246253 cites W2993925079 @default.
• W3113246253 cites W2994331021 @default.
• W3113246253 cites W2997943836 @default.
• W3113246253 cites W2998659801 @default.
• W3113246253 cites W2998848433 @default.
• W3113246253 cites W3018818368 @default.
• W3113246253 cites W4211032970 @default.
• W3113246253 doi "https://doi.org/10.1007/s00262-020-02807-1" @default.
• W3113246253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8139937" @default.
• W3113246253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33301062" @default.
• W3113246253 hasPublicationYear "2020" @default.
• W3113246253 type Work @default.
• W3113246253 sameAs 3113246253 @default.
• W3113246253 citedByCount "7" @default.
• W3113246253 countsByYear W31132462532021 @default.
• W3113246253 countsByYear W31132462532022 @default.
• W3113246253 countsByYear W31132462532023 @default.
• W3113246253 crossrefType "journal-article" @default.
• W3113246253 hasAuthorship W3113246253A5004341112 @default.
• W3113246253 hasAuthorship W3113246253A5029671704 @default.
• W3113246253 hasAuthorship W3113246253A5050999545 @default.
• W3113246253 hasAuthorship W3113246253A5064323494 @default.
• W3113246253 hasAuthorship W3113246253A5077503025 @default.
• W3113246253 hasBestOaLocation W31132462531 @default.
• W3113246253 hasConcept C104317684 @default.
• W3113246253 hasConcept C121608353 @default.
• W3113246253 hasConcept C150194340 @default.
• W3113246253 hasConcept C154317977 @default.
• W3113246253 hasConcept C202751555 @default.
• W3113246253 hasConcept C203014093 @default.
• W3113246253 hasConcept C2776090121 @default.
• W3113246253 hasConcept C2777701055 @default.
• W3113246253 hasConcept C2778326572 @default.
• W3113246253 hasConcept C2780110267 @default.
• W3113246253 hasConcept C502942594 @default.

• next