Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113256552> ?p ?o ?g. }
- W3113256552 endingPage "115946" @default.
- W3113256552 startingPage "115946" @default.
- W3113256552 abstract "Antibody-protein conjugates have been useful tools for studying biological systems and also played important roles in developing therapeutics and diagnostics. In particular, because of the increased interest in therapeutics of complexity higher than monoclonal antibodies, various methods have been reported for generating bispecific antibodies, immunotoxins, and antibody-enzyme conjugates in which antibodies are site-specifically conjugated with other proteins. Compared with conjugating antibodies with synthetic molecules, controlling the modification sites is difficult in the antibodies conjugated with protein cargos due to the presence of several reactive groups in both molecules. Enzymatic reactions are often used to generate antibody-protein conjugates owing to their high specificity for both reactants and products. Chemical modifications involving genetic introduction of natural or unnatural amino acid residues have also been used for site-specific conjugation of antibodies. Recent studies have developed methods to modify native antibodies using peptides having affinity for antibodies, and these methods do not need antibody engineering for conjugation reactions. In this review, we have summarized enzymatic and chemical approaches to generate site-specific antibody-protein conjugates." @default.
- W3113256552 created "2020-12-21" @default.
- W3113256552 creator A5034150631 @default.
- W3113256552 creator A5073280158 @default.
- W3113256552 creator A5084333246 @default.
- W3113256552 creator A5088377651 @default.
- W3113256552 date "2021-01-01" @default.
- W3113256552 modified "2023-09-26" @default.
- W3113256552 title "Methods to generate site-specific conjugates of antibody and protein" @default.
- W3113256552 cites W1162120243 @default.
- W3113256552 cites W121060991 @default.
- W3113256552 cites W1555522876 @default.
- W3113256552 cites W1670498114 @default.
- W3113256552 cites W1761681552 @default.
- W3113256552 cites W1921766784 @default.
- W3113256552 cites W1964788865 @default.
- W3113256552 cites W1964969705 @default.
- W3113256552 cites W1971093707 @default.
- W3113256552 cites W1973888120 @default.
- W3113256552 cites W1974737102 @default.
- W3113256552 cites W1976672416 @default.
- W3113256552 cites W1978945144 @default.
- W3113256552 cites W1983639577 @default.
- W3113256552 cites W1984111577 @default.
- W3113256552 cites W1989269073 @default.
- W3113256552 cites W1989418439 @default.
- W3113256552 cites W1990918213 @default.
- W3113256552 cites W1991420172 @default.
- W3113256552 cites W2000630217 @default.
- W3113256552 cites W2005458331 @default.
- W3113256552 cites W2007821505 @default.
- W3113256552 cites W2007956601 @default.
- W3113256552 cites W2012373884 @default.
- W3113256552 cites W2015211335 @default.
- W3113256552 cites W2015476804 @default.
- W3113256552 cites W2017609679 @default.
- W3113256552 cites W2021084977 @default.
- W3113256552 cites W2021375726 @default.
- W3113256552 cites W2023034663 @default.
- W3113256552 cites W2024854170 @default.
- W3113256552 cites W2027401035 @default.
- W3113256552 cites W2030249962 @default.
- W3113256552 cites W2031094737 @default.
- W3113256552 cites W2031191645 @default.
- W3113256552 cites W2031249985 @default.
- W3113256552 cites W2034650726 @default.
- W3113256552 cites W2036644678 @default.
- W3113256552 cites W2039928024 @default.
- W3113256552 cites W2050557902 @default.
- W3113256552 cites W2052156572 @default.
- W3113256552 cites W2055342376 @default.
- W3113256552 cites W2056405796 @default.
- W3113256552 cites W2059421155 @default.
- W3113256552 cites W2060391020 @default.
- W3113256552 cites W2062017343 @default.
- W3113256552 cites W2064641208 @default.
- W3113256552 cites W2064729690 @default.
- W3113256552 cites W2066960839 @default.
- W3113256552 cites W2067110167 @default.
- W3113256552 cites W2071033460 @default.
- W3113256552 cites W2071281151 @default.
- W3113256552 cites W2072125456 @default.
- W3113256552 cites W2073180572 @default.
- W3113256552 cites W2073504261 @default.
- W3113256552 cites W2077785805 @default.
- W3113256552 cites W2084922131 @default.
- W3113256552 cites W2088005853 @default.
- W3113256552 cites W2092479373 @default.
- W3113256552 cites W2095328296 @default.
- W3113256552 cites W2097100275 @default.
- W3113256552 cites W2100272194 @default.
- W3113256552 cites W2103563524 @default.
- W3113256552 cites W2104722248 @default.
- W3113256552 cites W2104725270 @default.
- W3113256552 cites W2109515907 @default.
- W3113256552 cites W2116150122 @default.
- W3113256552 cites W2126183505 @default.
- W3113256552 cites W2126473448 @default.
- W3113256552 cites W2140738105 @default.
- W3113256552 cites W2148313902 @default.
- W3113256552 cites W2150244588 @default.
- W3113256552 cites W2150427022 @default.
- W3113256552 cites W2151007289 @default.
- W3113256552 cites W2153061195 @default.
- W3113256552 cites W2157828104 @default.
- W3113256552 cites W2159101704 @default.
- W3113256552 cites W2168236728 @default.
- W3113256552 cites W2183643866 @default.
- W3113256552 cites W2209221218 @default.
- W3113256552 cites W2269735399 @default.
- W3113256552 cites W2290311814 @default.
- W3113256552 cites W2290712119 @default.
- W3113256552 cites W2307272104 @default.
- W3113256552 cites W2309076462 @default.
- W3113256552 cites W2321496780 @default.
- W3113256552 cites W2326085690 @default.
- W3113256552 cites W2327899001 @default.
- W3113256552 cites W2335018319 @default.