FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113262180> ?p ?o ?g. }

• W3113262180 abstract "Abstract Background Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbidities lead to these negative outcomes and whether they could influence ILD disease progression. The goal of this study was to identify clusters of patients based on similar comorbidity profiles and to determine whether these clusters were associated with rate of lung function decline and/or mortality. Methods Patients with a major fibrotic ILD (idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis, connective tissue disease-associated ILD, and unclassifiable ILD) from the CAnadian REgistry for Pulmonary Fibrosis (CARE-PF) were included. Hierarchical agglomerative clustering of comorbidities, age, sex, and smoking pack-years was conducted for each ILD subtype to identify combinations of these features that frequently occurred together in patients. The association between clusters and change in lung function over time was determined using linear mixed effects modeling, with adjustment for age, sex, and smoking pack-years. Kaplan Meier curves were used to assess differences in survival between the clusters. Results Discrete clusters were identified within each fibrotic ILD. In IPF, males with obstructive sleep apnea (OSA) had more rapid decline in FVC %-predicted (− 11.9% per year [95% CI − 15.3, − 8.5]) compared to females without any comorbidities (− 8.1% per year [95% CI − 13.6, − 2.7]; p = 0.03). Females without comorbidities also had significantly longer survival compared to all other IPF clusters. There were no significant differences in rate of lung function decline or survival between clusters in the other fibrotic ILD subtypes. Conclusions The combination of male sex and OSA may portend worse outcomes in IPF. Further research is required to elucidate the interplay between sex and comorbidities in ILD, as well as the role of OSA in ILD disease progression." @default.
• W3113262180 created "2020-12-21" @default.
• W3113262180 creator A5001470140 @default.
• W3113262180 creator A5002523848 @default.
• W3113262180 creator A5004657168 @default.
• W3113262180 creator A5009862886 @default.
• W3113262180 creator A5016809126 @default.
• W3113262180 creator A5019434255 @default.
• W3113262180 creator A5022407246 @default.
• W3113262180 creator A5023270797 @default.
• W3113262180 creator A5033032729 @default.
• W3113262180 creator A5033382458 @default.
• W3113262180 creator A5036033512 @default.
• W3113262180 creator A5044533146 @default.
• W3113262180 creator A5054105827 @default.
• W3113262180 creator A5063687930 @default.
• W3113262180 creator A5065730561 @default.
• W3113262180 creator A5071091208 @default.
• W3113262180 creator A5072315274 @default.
• W3113262180 creator A5074594962 @default.
• W3113262180 creator A5078877643 @default.
• W3113262180 creator A5091415199 @default.
• W3113262180 date "2020-12-01" @default.
• W3113262180 modified "2023-10-03" @default.
• W3113262180 title "A cluster-based analysis evaluating the impact of comorbidities in fibrotic interstitial lung disease" @default.
• W3113262180 cites W1888618913 @default.
• W3113262180 cites W1987971958 @default.
• W3113262180 cites W1993559550 @default.
• W3113262180 cites W2000445173 @default.
• W3113262180 cites W2016381774 @default.
• W3113262180 cites W2071949631 @default.
• W3113262180 cites W2102305559 @default.
• W3113262180 cites W2136410669 @default.
• W3113262180 cites W2154692607 @default.
• W3113262180 cites W2328539250 @default.
• W3113262180 cites W2416914730 @default.
• W3113262180 cites W2549978750 @default.
• W3113262180 cites W2611007056 @default.
• W3113262180 cites W2612940703 @default.
• W3113262180 cites W2741661620 @default.
• W3113262180 cites W2805082277 @default.
• W3113262180 cites W2805747221 @default.
• W3113262180 cites W2886931694 @default.
• W3113262180 cites W2927248259 @default.
• W3113262180 cites W2981067716 @default.
• W3113262180 cites W2991449905 @default.
• W3113262180 cites W2992207980 @default.
• W3113262180 doi "https://doi.org/10.1186/s12931-020-01579-7" @default.
• W3113262180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7720501" @default.
• W3113262180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33287805" @default.
• W3113262180 hasPublicationYear "2020" @default.
• W3113262180 type Work @default.
• W3113262180 sameAs 3113262180 @default.
• W3113262180 citedByCount "15" @default.
• W3113262180 countsByYear W31132621802021 @default.
• W3113262180 countsByYear W31132621802022 @default.
• W3113262180 countsByYear W31132621802023 @default.
• W3113262180 crossrefType "journal-article" @default.
• W3113262180 hasAuthorship W3113262180A5001470140 @default.
• W3113262180 hasAuthorship W3113262180A5002523848 @default.
• W3113262180 hasAuthorship W3113262180A5004657168 @default.
• W3113262180 hasAuthorship W3113262180A5009862886 @default.
• W3113262180 hasAuthorship W3113262180A5016809126 @default.
• W3113262180 hasAuthorship W3113262180A5019434255 @default.
• W3113262180 hasAuthorship W3113262180A5022407246 @default.
• W3113262180 hasAuthorship W3113262180A5023270797 @default.
• W3113262180 hasAuthorship W3113262180A5033032729 @default.
• W3113262180 hasAuthorship W3113262180A5033382458 @default.
• W3113262180 hasAuthorship W3113262180A5036033512 @default.
• W3113262180 hasAuthorship W3113262180A5044533146 @default.
• W3113262180 hasAuthorship W3113262180A5054105827 @default.
• W3113262180 hasAuthorship W3113262180A5063687930 @default.
• W3113262180 hasAuthorship W3113262180A5065730561 @default.
• W3113262180 hasAuthorship W3113262180A5071091208 @default.
• W3113262180 hasAuthorship W3113262180A5072315274 @default.
• W3113262180 hasAuthorship W3113262180A5074594962 @default.
• W3113262180 hasAuthorship W3113262180A5078877643 @default.
• W3113262180 hasAuthorship W3113262180A5091415199 @default.
• W3113262180 hasBestOaLocation W31132621801 @default.
• W3113262180 hasConcept C126322002 @default.
• W3113262180 hasConcept C16020263 @default.
• W3113262180 hasConcept C165637977 @default.
• W3113262180 hasConcept C2777134676 @default.
• W3113262180 hasConcept C2777543607 @default.
• W3113262180 hasConcept C2777714996 @default.
• W3113262180 hasConcept C2778341716 @default.
• W3113262180 hasConcept C2779159551 @default.
• W3113262180 hasConcept C2781244666 @default.
• W3113262180 hasConcept C3018587741 @default.
• W3113262180 hasConcept C71924100 @default.
• W3113262180 hasConcept C75603125 @default.
• W3113262180 hasConceptScore W3113262180C126322002 @default.
• W3113262180 hasConceptScore W3113262180C16020263 @default.
• W3113262180 hasConceptScore W3113262180C165637977 @default.
• W3113262180 hasConceptScore W3113262180C2777134676 @default.
• W3113262180 hasConceptScore W3113262180C2777543607 @default.
• W3113262180 hasConceptScore W3113262180C2777714996 @default.
• W3113262180 hasConceptScore W3113262180C2778341716 @default.
• W3113262180 hasConceptScore W3113262180C2779159551 @default.
• W3113262180 hasConceptScore W3113262180C2781244666 @default.

• next