FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113282942> ?p ?o ?g. }

• W3113282942 endingPage "192" @default.
• W3113282942 startingPage "186" @default.
• W3113282942 abstract "Platelet-derived growth factor receptor alpha (PDGFRα) is a dominant marker of mesodermal mesenchymal cells in mice. Previous studies demonstrated that PDGFRα-positive (PDGFRα+) mesodermal cells develop not only into mesenchymal cells but also into a subset of total hematopoietic cells (HCs) in the limited period during mouse embryogenesis. However, the precise characteristics of the PDGFRα lineage positive (PDGFRα Lin+) HCs in adult mouse hematopoiesis are largely unknown. In this study, we systematically evaluated the characteristics of PDGFRα Lin+ HCs in the bone marrow and peripheral blood using PDGFRα-CRE; ROSAtdTomato mice. Flow cytometry analysis revealed that PDGFRα Lin+ HCs accounted for approximately 20% of total HCs in both the bone marrow and peripheral blood in adult mice. Compositions of myeloid and lymphoid subpopulations among CD45+ mononuclear cells were almost identical in both PDGFRα Lin+ and PDGFRα Lin− cells. Single-cell RNA-sequencing analysis also demonstrated that the transcriptomic signatures of the PDGFRα Lin+ HCs in the peripheral blood largely overlapped with those of the PDGFRα Lin− HCs, suggesting equivalent functions of the PDGFRα Lin+ and PDGFRα Lin− HCs. Although pathophysiological activities of the PDGFRα Lin + HCs were not evaluated, our data clearly demonstrate a significant role of the PDGFRα Lin + HCs in physiological hematopoiesis in adult mice." @default.
• W3113282942 created "2020-12-21" @default.
• W3113282942 creator A5009819704 @default.
• W3113282942 creator A5013073310 @default.
• W3113282942 creator A5032090126 @default.
• W3113282942 creator A5045755554 @default.
• W3113282942 creator A5049195416 @default.
• W3113282942 creator A5052934233 @default.
• W3113282942 creator A5060007932 @default.
• W3113282942 creator A5062019634 @default.
• W3113282942 creator A5068655833 @default.
• W3113282942 creator A5091299917 @default.
• W3113282942 date "2021-01-01" @default.
• W3113282942 modified "2023-09-26" @default.
• W3113282942 title "Contribution of PDGFRα lineage cells in adult mouse hematopoiesis" @default.
• W3113282942 cites W1508174906 @default.
• W3113282942 cites W1512208922 @default.
• W3113282942 cites W1585570459 @default.
• W3113282942 cites W1589898379 @default.
• W3113282942 cites W1611185316 @default.
• W3113282942 cites W1948282121 @default.
• W3113282942 cites W1970669095 @default.
• W3113282942 cites W1971559485 @default.
• W3113282942 cites W1976747229 @default.
• W3113282942 cites W1984883254 @default.
• W3113282942 cites W2011712807 @default.
• W3113282942 cites W2014701358 @default.
• W3113282942 cites W2019552331 @default.
• W3113282942 cites W2030242394 @default.
• W3113282942 cites W2042982622 @default.
• W3113282942 cites W2083035091 @default.
• W3113282942 cites W2104135721 @default.
• W3113282942 cites W2107908886 @default.
• W3113282942 cites W2113596632 @default.
• W3113282942 cites W2150409084 @default.
• W3113282942 cites W2153406260 @default.
• W3113282942 cites W2155214429 @default.
• W3113282942 cites W2166323322 @default.
• W3113282942 cites W2169456326 @default.
• W3113282942 cites W2582033455 @default.
• W3113282942 cites W2594510643 @default.
• W3113282942 cites W2747877289 @default.
• W3113282942 cites W2786737923 @default.
• W3113282942 cites W2799273685 @default.
• W3113282942 cites W2913135006 @default.
• W3113282942 cites W2915103758 @default.
• W3113282942 cites W2916020270 @default.
• W3113282942 cites W2938129786 @default.
• W3113282942 cites W4361866794 @default.
• W3113282942 cites W658050074 @default.
• W3113282942 doi "https://doi.org/10.1016/j.bbrc.2020.11.114" @default.
• W3113282942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33309273" @default.
• W3113282942 hasPublicationYear "2021" @default.
• W3113282942 type Work @default.
• W3113282942 sameAs 3113282942 @default.
• W3113282942 citedByCount "2" @default.
• W3113282942 countsByYear W31132829422021 @default.
• W3113282942 countsByYear W31132829422022 @default.
• W3113282942 crossrefType "journal-article" @default.
• W3113282942 hasAuthorship W3113282942A5009819704 @default.
• W3113282942 hasAuthorship W3113282942A5013073310 @default.
• W3113282942 hasAuthorship W3113282942A5032090126 @default.
• W3113282942 hasAuthorship W3113282942A5045755554 @default.
• W3113282942 hasAuthorship W3113282942A5049195416 @default.
• W3113282942 hasAuthorship W3113282942A5052934233 @default.
• W3113282942 hasAuthorship W3113282942A5060007932 @default.
• W3113282942 hasAuthorship W3113282942A5062019634 @default.
• W3113282942 hasAuthorship W3113282942A5068655833 @default.
• W3113282942 hasAuthorship W3113282942A5091299917 @default.
• W3113282942 hasBestOaLocation W31132829421 @default.
• W3113282942 hasConcept C109159458 @default.
• W3113282942 hasConcept C153911025 @default.
• W3113282942 hasConcept C170493617 @default.
• W3113282942 hasConcept C180361614 @default.
• W3113282942 hasConcept C198826908 @default.
• W3113282942 hasConcept C203014093 @default.
• W3113282942 hasConcept C2775960820 @default.
• W3113282942 hasConcept C2780007613 @default.
• W3113282942 hasConcept C28328180 @default.
• W3113282942 hasConcept C502942594 @default.
• W3113282942 hasConcept C54355233 @default.
• W3113282942 hasConcept C553184892 @default.
• W3113282942 hasConcept C86803240 @default.
• W3113282942 hasConcept C95444343 @default.
• W3113282942 hasConceptScore W3113282942C109159458 @default.
• W3113282942 hasConceptScore W3113282942C153911025 @default.
• W3113282942 hasConceptScore W3113282942C170493617 @default.
• W3113282942 hasConceptScore W3113282942C180361614 @default.
• W3113282942 hasConceptScore W3113282942C198826908 @default.
• W3113282942 hasConceptScore W3113282942C203014093 @default.
• W3113282942 hasConceptScore W3113282942C2775960820 @default.
• W3113282942 hasConceptScore W3113282942C2780007613 @default.
• W3113282942 hasConceptScore W3113282942C28328180 @default.
• W3113282942 hasConceptScore W3113282942C502942594 @default.
• W3113282942 hasConceptScore W3113282942C54355233 @default.
• W3113282942 hasConceptScore W3113282942C553184892 @default.
• W3113282942 hasConceptScore W3113282942C86803240 @default.
• W3113282942 hasConceptScore W3113282942C95444343 @default.

• next