Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113288312> ?p ?o ?g. }
- W3113288312 abstract "Abstract Background The purpose of this study was to characterize subtype-specific patterns of mRNA and miRNA expression of gliomas using The Cancer Genome Atlas (TCGA) data to search for genetic determinants that predict prognosis in terms of overall survival and to create interaction networks for grade 2 and 3 (G2 and G3) astrocytomas, oligodendrogliomas and grade 4 (G4) glioblastoma multiforme. Based on open-access TCGA data, 5 groups were formed: astrocytoma G2 ( n = 58), astrocytoma G3 ( n = 128), oligodendroglioma G2 ( n = 102), oligodendroglioma G3 ( n = 72) and glioblastoma G4 ( n = 564); normal samples of brain tissue were also analysed ( n = 15). Data of patient age, sex, survival and expression patterns of mRNA and miRNA were extracted for each sample. After stratification of the data into groups, a differential analysis of expression was carried out, genes and miRNAs that affect overall survival were identified and gene set enrichment analysis (GSEA) and interaction analysis were performed. Results A total of 939 samples of glial tumours were analysed, for which subtype-specific expression profiles of genes and miRNAs were identified and networks of mRNA-miRNA interactions were constructed. Genes whose aberrant expression level was associated with survival were determined, and pairwise correlations between differential gene expression (DEG) and differential miRNA expression (DE miRNA) were calculated. Conclusions The developed panel of genes and miRNAs allowed us to differentiate glioma subtypes and evaluate prognosis in terms of the overall survival of patients. The regulatory miRNA-mRNA pairs unique to the five glioma subtypes identified in this study can stimulate the development of new therapeutic approaches based on subtype-specific mechanisms of oncogenesis." @default.
- W3113288312 created "2020-12-21" @default.
- W3113288312 creator A5010631442 @default.
- W3113288312 creator A5011556547 @default.
- W3113288312 creator A5042167954 @default.
- W3113288312 creator A5047693147 @default.
- W3113288312 creator A5048574633 @default.
- W3113288312 creator A5052728033 @default.
- W3113288312 date "2020-12-01" @default.
- W3113288312 modified "2023-10-16" @default.
- W3113288312 title "Integrative analysis of mRNA and miRNA sequencing data for gliomas of various grades" @default.
- W3113288312 cites W1565226021 @default.
- W3113288312 cites W1741277085 @default.
- W3113288312 cites W1944500389 @default.
- W3113288312 cites W1958510895 @default.
- W3113288312 cites W1971806005 @default.
- W3113288312 cites W1972898510 @default.
- W3113288312 cites W1977588066 @default.
- W3113288312 cites W2000110777 @default.
- W3113288312 cites W2001592430 @default.
- W3113288312 cites W2008006957 @default.
- W3113288312 cites W2018257233 @default.
- W3113288312 cites W2045228008 @default.
- W3113288312 cites W2067153802 @default.
- W3113288312 cites W2080632359 @default.
- W3113288312 cites W2081990073 @default.
- W3113288312 cites W2092974902 @default.
- W3113288312 cites W2146512944 @default.
- W3113288312 cites W2149840758 @default.
- W3113288312 cites W2150169404 @default.
- W3113288312 cites W2158217645 @default.
- W3113288312 cites W2171078630 @default.
- W3113288312 cites W2171641698 @default.
- W3113288312 cites W2230320310 @default.
- W3113288312 cites W2416509920 @default.
- W3113288312 cites W2559821250 @default.
- W3113288312 cites W2583273198 @default.
- W3113288312 cites W2595805911 @default.
- W3113288312 cites W2669859451 @default.
- W3113288312 cites W2744729288 @default.
- W3113288312 cites W2768224787 @default.
- W3113288312 cites W2773143448 @default.
- W3113288312 cites W2784313238 @default.
- W3113288312 cites W2785021707 @default.
- W3113288312 cites W2792021417 @default.
- W3113288312 cites W2801631623 @default.
- W3113288312 cites W2803694526 @default.
- W3113288312 cites W2886838525 @default.
- W3113288312 cites W2886979573 @default.
- W3113288312 cites W2887295684 @default.
- W3113288312 cites W2887621676 @default.
- W3113288312 cites W2895245849 @default.
- W3113288312 cites W2900482723 @default.
- W3113288312 cites W2900569176 @default.
- W3113288312 cites W2913461027 @default.
- W3113288312 cites W2913631768 @default.
- W3113288312 cites W2918705746 @default.
- W3113288312 cites W2932253769 @default.
- W3113288312 cites W2941154109 @default.
- W3113288312 cites W2943972251 @default.
- W3113288312 cites W2944252344 @default.
- W3113288312 cites W2952364808 @default.
- W3113288312 cites W2952528394 @default.
- W3113288312 cites W2964936150 @default.
- W3113288312 cites W2969806860 @default.
- W3113288312 cites W2982088187 @default.
- W3113288312 cites W2987536782 @default.
- W3113288312 cites W2989219981 @default.
- W3113288312 cites W2989474954 @default.
- W3113288312 cites W2990547145 @default.
- W3113288312 cites W2991422095 @default.
- W3113288312 cites W2999806445 @default.
- W3113288312 cites W3000088076 @default.
- W3113288312 cites W3000742620 @default.
- W3113288312 cites W3007105939 @default.
- W3113288312 cites W3008425127 @default.
- W3113288312 cites W3030461704 @default.
- W3113288312 doi "https://doi.org/10.1186/s43042-020-00119-8" @default.
- W3113288312 hasPublicationYear "2020" @default.
- W3113288312 type Work @default.
- W3113288312 sameAs 3113288312 @default.
- W3113288312 citedByCount "2" @default.
- W3113288312 countsByYear W31132883122022 @default.
- W3113288312 crossrefType "journal-article" @default.
- W3113288312 hasAuthorship W3113288312A5010631442 @default.
- W3113288312 hasAuthorship W3113288312A5011556547 @default.
- W3113288312 hasAuthorship W3113288312A5042167954 @default.
- W3113288312 hasAuthorship W3113288312A5047693147 @default.
- W3113288312 hasAuthorship W3113288312A5048574633 @default.
- W3113288312 hasAuthorship W3113288312A5052728033 @default.
- W3113288312 hasBestOaLocation W31132883121 @default.
- W3113288312 hasConcept C104317684 @default.
- W3113288312 hasConcept C10515644 @default.
- W3113288312 hasConcept C126322002 @default.
- W3113288312 hasConcept C143998085 @default.
- W3113288312 hasConcept C145059251 @default.
- W3113288312 hasConcept C150194340 @default.
- W3113288312 hasConcept C2777931997 @default.
- W3113288312 hasConcept C2778227246 @default.
- W3113288312 hasConcept C2778880634 @default.