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- W3113296670 endingPage "109888" @default.
- W3113296670 startingPage "109888" @default.
- W3113296670 abstract "The transdifferentiation of cardiac fibroblasts into myofibroblasts after cardiac injury has traditionally been defined by a unidirectional continuum from quiescent fibroblasts, through activated fibroblasts, and finally to fibrotic-matrix producing myofibroblasts. However, recent lineage tracing and single cell RNA sequencing experiments have demonstrated that fibroblast transdifferentiation is much more complex. Growing evidence suggests that fibroblasts are more heterogenous than previously thought, and many new cell states have recently been identified. This review reexamines conventional fibroblast transdifferentiation paradigms with a dynamic state space lens, which could enable a more complex understanding of how fibroblast state dynamics alters fibrotic remodeling of the heart. This review will define cellular state space, how it relates to fibroblast state transitions, and how the canonical and non-canonical fibrotic signaling pathways modulate fibroblast cell state and cardiac fibrosis. Finally, this review explores the therapeutic potential of fibroblast state space modulation by p38 inhibition, yes-associated protein (YAP) inhibition, and fibroblast reprogramming." @default.
- W3113296670 created "2020-12-21" @default.
- W3113296670 creator A5074555498 @default.
- W3113296670 creator A5077720958 @default.
- W3113296670 creator A5085011121 @default.
- W3113296670 creator A5089585757 @default.
- W3113296670 date "2021-03-01" @default.
- W3113296670 modified "2023-10-06" @default.
- W3113296670 title "Controlling cardiac fibrosis through fibroblast state space modulation" @default.
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