FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113304017> ?p ?o ?g. }

• W3113304017 endingPage "97" @default.
• W3113304017 startingPage "88" @default.
• W3113304017 abstract "Background and objectives Zolpidem, a nonbenzodiazepine hypnotic, and trazodone, a sedating antidepressant, are the most common medications used to treat insomnia in the United States. Both drugs have side effect profiles ( e.g ., drowsiness, dizziness, and cognitive and motor impairment) that can heighten the risk of falls and fractures. Despite widespread zolpidem and trazodone use, little is known about the comparative safety of these medications in patients receiving hemodialysis, a vulnerable population with an exceedingly high fracture rate. Design, setting, participants, & measurements Using data from the United States Renal Data System registry (2013–2016), we conducted a retrospective cohort study to investigate the association between the initiation of zolpidem versus trazodone therapy and the 30-day risk of hospitalized fall-related fractures among Medicare-enrolled patients receiving maintenance hemodialysis. We used an active comparator new-user design and estimated 30-day inverse probability of treatment-weighted hazard ratios and risk differences. We treated death as a competing event. Results A total of 31,055 patients were included: 18,941 zolpidem initiators (61%) and 12,114 trazodone initiators (39%). During the 30-day follow-up period, 101 fall-related fractures occurred. Zolpidem versus trazodone initiation was associated with a higher risk of hospitalized fall-related fracture (weighted hazard ratio, 1.71; 95% confidence interval, 1.11 to 2.63; weighted risk difference, 0.17%; 95% confidence interval, 0.07% to 0.29%). This association was more pronounced among individuals prescribed higher zolpidem doses (hazard ratio, 1.85; 95% confidence interval, 1.10 to 3.01; and risk difference, 0.20%; 95% confidence interval, 0.04% to 0.38% for higher-dose zolpidem versus trazodone; and hazard ratio, 1.60; 95% confidence interval, 1.01 to 2.55 and risk difference, 0.14%; 95% confidence interval, 0.03% to 0.27% for lower-dose zolpidem versus trazodone). Sensitivity analyses using longer follow-up durations yielded similar results. Conclusions Among individuals receiving maintenance hemodialysis, zolpidem initiators had a higher risk of hospitalized fall-related fracture compared with trazodone initiators. Podcast This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_12_18_CJN10070620_final.mp3" @default.
• W3113304017 created "2020-12-21" @default.
• W3113304017 creator A5059227564 @default.
• W3113304017 creator A5065254809 @default.
• W3113304017 date "2020-12-18" @default.
• W3113304017 modified "2023-10-17" @default.
• W3113304017 title "Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis" @default.
• W3113304017 cites W1515702051 @default.
• W3113304017 cites W1560983288 @default.
• W3113304017 cites W1755916079 @default.
• W3113304017 cites W1766949504 @default.
• W3113304017 cites W1849521086 @default.
• W3113304017 cites W1854036179 @default.
• W3113304017 cites W1943672390 @default.
• W3113304017 cites W1973441860 @default.
• W3113304017 cites W1986475474 @default.
• W3113304017 cites W1992463789 @default.
• W3113304017 cites W2009938720 @default.
• W3113304017 cites W2013946630 @default.
• W3113304017 cites W2027717614 @default.
• W3113304017 cites W2035240111 @default.
• W3113304017 cites W2038981426 @default.
• W3113304017 cites W2044170764 @default.
• W3113304017 cites W2049491523 @default.
• W3113304017 cites W2090369799 @default.
• W3113304017 cites W2094113973 @default.
• W3113304017 cites W2100329484 @default.
• W3113304017 cites W2100758700 @default.
• W3113304017 cites W2111180320 @default.
• W3113304017 cites W2121055261 @default.
• W3113304017 cites W2129537775 @default.
• W3113304017 cites W2136975742 @default.
• W3113304017 cites W2142495742 @default.
• W3113304017 cites W2148975058 @default.
• W3113304017 cites W2156680407 @default.
• W3113304017 cites W2164595809 @default.
• W3113304017 cites W2168458505 @default.
• W3113304017 cites W2347166707 @default.
• W3113304017 cites W2600488841 @default.
• W3113304017 cites W2740855840 @default.
• W3113304017 cites W2753866150 @default.
• W3113304017 cites W2791355981 @default.
• W3113304017 cites W2900179362 @default.
• W3113304017 cites W2910074233 @default.
• W3113304017 cites W3013344672 @default.
• W3113304017 cites W3123582712 @default.
• W3113304017 cites W4241984066 @default.
• W3113304017 doi "https://doi.org/10.2215/cjn.10070620" @default.
• W3113304017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7792650" @default.
• W3113304017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33355192" @default.
• W3113304017 hasPublicationYear "2020" @default.
• W3113304017 type Work @default.
• W3113304017 sameAs 3113304017 @default.
• W3113304017 citedByCount "2" @default.
• W3113304017 countsByYear W31133040172021 @default.
• W3113304017 countsByYear W31133040172022 @default.
• W3113304017 crossrefType "journal-article" @default.
• W3113304017 hasAuthorship W3113304017A5059227564 @default.
• W3113304017 hasAuthorship W3113304017A5065254809 @default.
• W3113304017 hasBestOaLocation W31133040171 @default.
• W3113304017 hasConcept C118552586 @default.
• W3113304017 hasConcept C126322002 @default.
• W3113304017 hasConcept C201903717 @default.
• W3113304017 hasConcept C207103383 @default.
• W3113304017 hasConcept C2777123777 @default.
• W3113304017 hasConcept C2779177272 @default.
• W3113304017 hasConcept C2780930544 @default.
• W3113304017 hasConcept C2780980600 @default.
• W3113304017 hasConcept C2781161787 @default.
• W3113304017 hasConcept C2781210498 @default.
• W3113304017 hasConcept C42219234 @default.
• W3113304017 hasConcept C44249647 @default.
• W3113304017 hasConcept C50382708 @default.
• W3113304017 hasConcept C71924100 @default.
• W3113304017 hasConcept C72563966 @default.
• W3113304017 hasConceptScore W3113304017C118552586 @default.
• W3113304017 hasConceptScore W3113304017C126322002 @default.
• W3113304017 hasConceptScore W3113304017C201903717 @default.
• W3113304017 hasConceptScore W3113304017C207103383 @default.
• W3113304017 hasConceptScore W3113304017C2777123777 @default.
• W3113304017 hasConceptScore W3113304017C2779177272 @default.
• W3113304017 hasConceptScore W3113304017C2780930544 @default.
• W3113304017 hasConceptScore W3113304017C2780980600 @default.
• W3113304017 hasConceptScore W3113304017C2781161787 @default.
• W3113304017 hasConceptScore W3113304017C2781210498 @default.
• W3113304017 hasConceptScore W3113304017C42219234 @default.
• W3113304017 hasConceptScore W3113304017C44249647 @default.
• W3113304017 hasConceptScore W3113304017C50382708 @default.
• W3113304017 hasConceptScore W3113304017C71924100 @default.
• W3113304017 hasConceptScore W3113304017C72563966 @default.
• W3113304017 hasFunder F4320337338 @default.
• W3113304017 hasFunder F4320337357 @default.
• W3113304017 hasIssue "1" @default.
• W3113304017 hasLocation W31133040171 @default.
• W3113304017 hasLocation W31133040172 @default.
• W3113304017 hasLocation W31133040173 @default.
• W3113304017 hasOpenAccess W3113304017 @default.
• W3113304017 hasPrimaryLocation W31133040171 @default.

• next