Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113306941> ?p ?o ?g. }
- W3113306941 endingPage "509" @default.
- W3113306941 startingPage "509" @default.
- W3113306941 abstract "Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we delineated a lipidomic profile of human ccRCC and integrated it with transcriptomic data to connect the variations in cancer lipid metabolism with gene expression changes. Untargeted lipidomic analysis was performed on 20 ccRCC and 20 paired normal tissues, using LC-MS and GC-MS. Different lipid classes were altered in cancer compared to normal tissue. Among the long chain fatty acids (LCFAs), significant accumulations of polyunsaturated fatty acids (PUFAs) were found. Integrated lipidomic and transcriptomic analysis showed that fatty acid desaturation and elongation pathways were enriched in neoplastic tissue. Consistent with these findings, we observed increased expression of stearoyl-CoA desaturase (SCD1) and FA elongase 2 and 5 in ccRCC. Primary renal cancer cells treated with a small molecule SCD1 inhibitor (A939572) proliferated at a slower rate than untreated cancer cells. In addition, after cisplatin treatment, the death rate of tumor cells treated with A939572 was significantly greater than that of untreated cancer cells. In conclusion, our findings delineate a ccRCC lipidomic signature and showed that SCD1 inhibition significantly reduced cancer cell proliferation and increased cisplatin sensitivity, suggesting that this pathway can be involved in ccRCC chemotherapy resistance." @default.
- W3113306941 created "2020-12-21" @default.
- W3113306941 creator A5001805404 @default.
- W3113306941 creator A5003929233 @default.
- W3113306941 creator A5005158952 @default.
- W3113306941 creator A5014614796 @default.
- W3113306941 creator A5016199324 @default.
- W3113306941 creator A5016563768 @default.
- W3113306941 creator A5018910230 @default.
- W3113306941 creator A5027115920 @default.
- W3113306941 creator A5031961999 @default.
- W3113306941 creator A5035120623 @default.
- W3113306941 creator A5045412958 @default.
- W3113306941 creator A5049932698 @default.
- W3113306941 creator A5063287766 @default.
- W3113306941 creator A5070965901 @default.
- W3113306941 creator A5074106135 @default.
- W3113306941 creator A5076196380 @default.
- W3113306941 creator A5082488218 @default.
- W3113306941 date "2020-12-13" @default.
- W3113306941 modified "2023-10-16" @default.
- W3113306941 title "Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma" @default.
- W3113306941 cites W1811633309 @default.
- W3113306941 cites W1842974971 @default.
- W3113306941 cites W1965037168 @default.
- W3113306941 cites W1969356185 @default.
- W3113306941 cites W1977918192 @default.
- W3113306941 cites W1996856207 @default.
- W3113306941 cites W2010481923 @default.
- W3113306941 cites W2034084750 @default.
- W3113306941 cites W2039337809 @default.
- W3113306941 cites W2068983744 @default.
- W3113306941 cites W2091309005 @default.
- W3113306941 cites W2098002429 @default.
- W3113306941 cites W2130410032 @default.
- W3113306941 cites W2130998543 @default.
- W3113306941 cites W2135546443 @default.
- W3113306941 cites W2152171769 @default.
- W3113306941 cites W2168347591 @default.
- W3113306941 cites W2234445408 @default.
- W3113306941 cites W2263594271 @default.
- W3113306941 cites W2312326516 @default.
- W3113306941 cites W2312595260 @default.
- W3113306941 cites W2326971616 @default.
- W3113306941 cites W2335012284 @default.
- W3113306941 cites W2474015507 @default.
- W3113306941 cites W2483136969 @default.
- W3113306941 cites W2496416327 @default.
- W3113306941 cites W2519193025 @default.
- W3113306941 cites W2519382239 @default.
- W3113306941 cites W2538218699 @default.
- W3113306941 cites W2570522603 @default.
- W3113306941 cites W2596082625 @default.
- W3113306941 cites W2601751358 @default.
- W3113306941 cites W2736209550 @default.
- W3113306941 cites W2766501219 @default.
- W3113306941 cites W2768435200 @default.
- W3113306941 cites W2771697100 @default.
- W3113306941 cites W2854223583 @default.
- W3113306941 cites W2889646458 @default.
- W3113306941 cites W2899384460 @default.
- W3113306941 cites W2904346214 @default.
- W3113306941 cites W2912844387 @default.
- W3113306941 cites W2916228564 @default.
- W3113306941 cites W2938217357 @default.
- W3113306941 cites W2939335764 @default.
- W3113306941 cites W2940967764 @default.
- W3113306941 cites W2946657092 @default.
- W3113306941 cites W2992374518 @default.
- W3113306941 cites W2995933411 @default.
- W3113306941 cites W2999240762 @default.
- W3113306941 cites W2999417355 @default.
- W3113306941 cites W3003818108 @default.
- W3113306941 cites W3003934465 @default.
- W3113306941 cites W3011462671 @default.
- W3113306941 cites W3017642268 @default.
- W3113306941 cites W3081803150 @default.
- W3113306941 cites W4251307143 @default.
- W3113306941 doi "https://doi.org/10.3390/metabo10120509" @default.
- W3113306941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7763669" @default.
- W3113306941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33322148" @default.
- W3113306941 hasPublicationYear "2020" @default.
- W3113306941 type Work @default.
- W3113306941 sameAs 3113306941 @default.
- W3113306941 citedByCount "43" @default.
- W3113306941 countsByYear W31133069412021 @default.
- W3113306941 countsByYear W31133069412022 @default.
- W3113306941 countsByYear W31133069412023 @default.
- W3113306941 crossrefType "journal-article" @default.
- W3113306941 hasAuthorship W3113306941A5001805404 @default.
- W3113306941 hasAuthorship W3113306941A5003929233 @default.
- W3113306941 hasAuthorship W3113306941A5005158952 @default.
- W3113306941 hasAuthorship W3113306941A5014614796 @default.
- W3113306941 hasAuthorship W3113306941A5016199324 @default.
- W3113306941 hasAuthorship W3113306941A5016563768 @default.
- W3113306941 hasAuthorship W3113306941A5018910230 @default.
- W3113306941 hasAuthorship W3113306941A5027115920 @default.
- W3113306941 hasAuthorship W3113306941A5031961999 @default.