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- W3113323193 endingPage "3688" @default.
- W3113323193 startingPage "3688" @default.
- W3113323193 abstract "This review is focused on lamin A/C, a nuclear protein with multiple functions in normal and diseased cells. Its functions, as known to date, are summarized. This summary includes its role in maintaining a cell’s structural stability, cell motility, mechanosensing, chromosome organization, gene regulation, cell differentiation, DNA damage repair, and telomere protection. As lamin A/C has a variety of critical roles within the cell, mutations of the lamin A/C gene and incorrect processing of the protein results in a wide variety of diseases, ranging from striated muscle disorders to accelerated aging diseases. These diseases, collectively termed laminopathies, are also touched upon. Finally, we review the existing evidence of lamin A/C’s deregulation in cancer. Lamin A/C deregulation leads to various traits, including genomic instability and increased tolerance to mechanical insult, which can lead to more aggressive cancer and poorer prognosis. As lamin A/C’s expression in specific cancers varies widely, currently known lamin A/C expression in various cancers is reviewed. Additionally, Lamin A/C’s potential as a biomarker in various cancers and as an aid in more accurately diagnosing intermediate Gleason score prostate cancers is also discussed." @default.
- W3113323193 created "2020-12-21" @default.
- W3113323193 creator A5062378722 @default.
- W3113323193 creator A5065512954 @default.
- W3113323193 date "2020-12-09" @default.
- W3113323193 modified "2023-10-16" @default.
- W3113323193 title "Lamin A/C: Function in Normal and Tumor Cells" @default.
- W3113323193 cites W143183448 @default.
- W3113323193 cites W1560616913 @default.
- W3113323193 cites W1568802323 @default.
- W3113323193 cites W1665551917 @default.
- W3113323193 cites W174244530 @default.
- W3113323193 cites W1810350704 @default.
- W3113323193 cites W1823005638 @default.
- W3113323193 cites W1967187334 @default.
- W3113323193 cites W1972838254 @default.
- W3113323193 cites W1978992677 @default.
- W3113323193 cites W1979043529 @default.
- W3113323193 cites W1983533553 @default.
- W3113323193 cites W1991816124 @default.
- W3113323193 cites W1999483295 @default.
- W3113323193 cites W2002219581 @default.
- W3113323193 cites W2002479625 @default.
- W3113323193 cites W2003250511 @default.
- W3113323193 cites W2003768435 @default.
- W3113323193 cites W2008052894 @default.
- W3113323193 cites W2010335932 @default.
- W3113323193 cites W2017572973 @default.
- W3113323193 cites W2017926450 @default.
- W3113323193 cites W2018275041 @default.
- W3113323193 cites W2022156993 @default.
- W3113323193 cites W2030637965 @default.
- W3113323193 cites W2031920140 @default.
- W3113323193 cites W2035244223 @default.
- W3113323193 cites W2035870858 @default.
- W3113323193 cites W2036565798 @default.
- W3113323193 cites W2052940791 @default.
- W3113323193 cites W2057700837 @default.
- W3113323193 cites W2061374206 @default.
- W3113323193 cites W2065520618 @default.
- W3113323193 cites W2066201562 @default.
- W3113323193 cites W2071624086 @default.
- W3113323193 cites W2072810104 @default.
- W3113323193 cites W2075565646 @default.
- W3113323193 cites W2089140165 @default.
- W3113323193 cites W2094180620 @default.
- W3113323193 cites W2096650383 @default.
- W3113323193 cites W2100268116 @default.
- W3113323193 cites W2112694870 @default.
- W3113323193 cites W2113915470 @default.
- W3113323193 cites W2119110453 @default.
- W3113323193 cites W2120930749 @default.
- W3113323193 cites W2126730593 @default.
- W3113323193 cites W2127659175 @default.
- W3113323193 cites W2138591519 @default.
- W3113323193 cites W2140132747 @default.
- W3113323193 cites W2140912045 @default.
- W3113323193 cites W2152051354 @default.
- W3113323193 cites W2160224424 @default.
- W3113323193 cites W2188508288 @default.
- W3113323193 cites W2198210185 @default.
- W3113323193 cites W2227469241 @default.
- W3113323193 cites W2261310019 @default.
- W3113323193 cites W2287005707 @default.
- W3113323193 cites W2320651766 @default.
- W3113323193 cites W2328465112 @default.
- W3113323193 cites W2338524367 @default.
- W3113323193 cites W2340707904 @default.
- W3113323193 cites W2469944791 @default.
- W3113323193 cites W2553978783 @default.
- W3113323193 cites W2560518865 @default.
- W3113323193 cites W2593053801 @default.
- W3113323193 cites W2598348069 @default.
- W3113323193 cites W2606633940 @default.
- W3113323193 cites W2618393344 @default.
- W3113323193 cites W2726161792 @default.
- W3113323193 cites W2748505872 @default.
- W3113323193 cites W2753802561 @default.
- W3113323193 cites W2754652505 @default.
- W3113323193 cites W2762877967 @default.
- W3113323193 cites W2766574774 @default.
- W3113323193 cites W2772204201 @default.
- W3113323193 cites W2781699305 @default.
- W3113323193 cites W2784360276 @default.
- W3113323193 cites W2790113156 @default.
- W3113323193 cites W2791021693 @default.
- W3113323193 cites W2797549363 @default.
- W3113323193 cites W2801605528 @default.
- W3113323193 cites W2802289775 @default.
- W3113323193 cites W2886507674 @default.
- W3113323193 cites W2886939826 @default.
- W3113323193 cites W2888385911 @default.
- W3113323193 cites W2889063028 @default.
- W3113323193 cites W2889516198 @default.
- W3113323193 cites W2893640779 @default.
- W3113323193 cites W2894393022 @default.
- W3113323193 cites W2895294327 @default.
- W3113323193 cites W2898633951 @default.