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- W3113402016 abstract "Spontaneous contractions of cardiomyocytes are driven by calcium oscillations due to the activity of ionic calcium channels and pumps. The beating phase is related to the time-dependent deviation of the oscillations from their average frequency, due to noise and the resulting cellular response. Here, we demonstrate experimentally that, in addition to the short-time (1--2 Hz), beat-to-beat variability, there are long-time correlations (tens of minutes) in the beating phase dynamics of isolated cardiomyocytes. Our theoretical model relates these long-time correlations to cellular regulation that restores the frequency to its average, homeostatic value in response to stochastic perturbations." @default.
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- W3113402016 date "2020-12-18" @default.
- W3113402016 modified "2023-09-24" @default.
- W3113402016 title "Long-Time Phase Correlations Reveal Regulation of Beating Cardiomyocytes" @default.
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- W3113402016 doi "https://doi.org/10.1103/physrevlett.125.258101" @default.
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