FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113441794> ?p ?o ?g. }

• W3113441794 endingPage "1444" @default.
• W3113441794 startingPage "1426" @default.
• W3113441794 abstract "Background and Purpose The peptide hormone vasopressin regulates water transport in the renal collecting duct largely via the V2 receptor, which triggers a cAMP-mediated activation of a PKA-dependent signalling network. The protein kinases downstream from PKA have not been fully identified or mapped to regulated phosphoproteins. Experimental Approach We carried out systems-level analysis of large-scale phosphoproteomic data quantifying vasopressin-induced changes in phosphorylation in aquaporin-2-expressing cultured collecting duct (mpkCCD) cells. Quantification was done using stable isotope labelling (SILAC method). Key Results Nine thousand six hundred forty phosphopeptides were quantified. Stringent statistical analysis identified significant changes in response to vasopressin in 429 of these phosphopeptides. The corresponding phosphoproteins were mapped to known vasopressin-regulated cellular processes. The vasopressin-regulated sites were classified according to the sequences surrounding the phosphorylated amino acids giving 11 groups. Among the vasopressin-regulated phosphoproteins were 25 distinct protein kinases. Among these, six plus PKA appeared to account for phosphorylation of about 81% of the 313 vasopressin-regulated phosphorylation sites. The six downstream kinases were salt-inducible kinase 2 (Sik2), cyclin-dependent kinase 18 (Cdk18), calmodulin-dependent kinase kinase 2 (Camkk2), protein kinase D2 (Prkd2), mitogen-activated kinase 3 (Mapk3) and myosin light chain kinase (Mylk). Conclusion and Implications In V2 receptor-mediated signalling, PKA is at the head of a complex network that includes at least six downstream vasopressin-regulated protein kinases that are prime targets for future study. The extensive phosphoproteomic data reported in this study are provided as a web-based data resource for future studies of GPCRs. [Correction added on 4 March 2021, after first online publication: The first sentence in the Key Results was corrected in this current version.]" @default.
• W3113441794 created "2021-01-05" @default.
• W3113441794 creator A5010454251 @default.
• W3113441794 creator A5011711334 @default.
• W3113441794 creator A5024500155 @default.
• W3113441794 creator A5029048638 @default.
• W3113441794 creator A5069722362 @default.
• W3113441794 creator A5070229736 @default.
• W3113441794 creator A5087681217 @default.
• W3113441794 date "2021-02-14" @default.
• W3113441794 modified "2023-10-12" @default.
• W3113441794 title "Phosphoproteomic identification of vasopressin‐regulated protein kinases in collecting duct cells" @default.
• W3113441794 cites W1548348246 @default.
• W3113441794 cites W1800388541 @default.
• W3113441794 cites W1905659291 @default.
• W3113441794 cites W1952592959 @default.
• W3113441794 cites W1988993398 @default.
• W3113441794 cites W1990043183 @default.
• W3113441794 cites W1993471526 @default.
• W3113441794 cites W1998349282 @default.
• W3113441794 cites W2004182894 @default.
• W3113441794 cites W2012223636 @default.
• W3113441794 cites W2015039564 @default.
• W3113441794 cites W2016833860 @default.
• W3113441794 cites W2022312613 @default.
• W3113441794 cites W2027774453 @default.
• W3113441794 cites W2028405047 @default.
• W3113441794 cites W2030205108 @default.
• W3113441794 cites W2036411765 @default.
• W3113441794 cites W2040196938 @default.
• W3113441794 cites W2041121472 @default.
• W3113441794 cites W2045381482 @default.
• W3113441794 cites W2048965703 @default.
• W3113441794 cites W2051262014 @default.
• W3113441794 cites W2069730161 @default.
• W3113441794 cites W2079331198 @default.
• W3113441794 cites W2095454212 @default.
• W3113441794 cites W2097548343 @default.
• W3113441794 cites W2098927359 @default.
• W3113441794 cites W2107115930 @default.
• W3113441794 cites W2112643254 @default.
• W3113441794 cites W2113221012 @default.
• W3113441794 cites W2120040647 @default.
• W3113441794 cites W2121199901 @default.
• W3113441794 cites W2128870011 @default.
• W3113441794 cites W2131646216 @default.
• W3113441794 cites W2132381454 @default.
• W3113441794 cites W2138231208 @default.
• W3113441794 cites W2139448535 @default.
• W3113441794 cites W2152653845 @default.
• W3113441794 cites W2154351186 @default.
• W3113441794 cites W2160536323 @default.
• W3113441794 cites W2172474583 @default.
• W3113441794 cites W2260454409 @default.
• W3113441794 cites W2313374221 @default.
• W3113441794 cites W2406525517 @default.
• W3113441794 cites W2531662801 @default.
• W3113441794 cites W2568182039 @default.
• W3113441794 cites W2750899741 @default.
• W3113441794 cites W2761688050 @default.
• W3113441794 cites W2762504941 @default.
• W3113441794 cites W2771328536 @default.
• W3113441794 cites W2773849864 @default.
• W3113441794 cites W2792530460 @default.
• W3113441794 cites W2804509374 @default.
• W3113441794 cites W2916357899 @default.
• W3113441794 cites W2948596130 @default.
• W3113441794 cites W2962513404 @default.
• W3113441794 cites W2964139615 @default.
• W3113441794 cites W2984194970 @default.
• W3113441794 cites W2987819628 @default.
• W3113441794 cites W3000675236 @default.
• W3113441794 cites W3010787029 @default.
• W3113441794 cites W3013370603 @default.
• W3113441794 cites W3014764427 @default.
• W3113441794 cites W3039180813 @default.
• W3113441794 cites W3086208975 @default.
• W3113441794 cites W4233060341 @default.
• W3113441794 doi "https://doi.org/10.1111/bph.15352" @default.
• W3113441794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33346914" @default.
• W3113441794 hasPublicationYear "2021" @default.
• W3113441794 type Work @default.
• W3113441794 sameAs 3113441794 @default.
• W3113441794 citedByCount "13" @default.
• W3113441794 countsByYear W31134417942021 @default.
• W3113441794 countsByYear W31134417942022 @default.
• W3113441794 countsByYear W31134417942023 @default.
• W3113441794 crossrefType "journal-article" @default.
• W3113441794 hasAuthorship W3113441794A5010454251 @default.
• W3113441794 hasAuthorship W3113441794A5011711334 @default.
• W3113441794 hasAuthorship W3113441794A5024500155 @default.
• W3113441794 hasAuthorship W3113441794A5029048638 @default.
• W3113441794 hasAuthorship W3113441794A5069722362 @default.
• W3113441794 hasAuthorship W3113441794A5070229736 @default.
• W3113441794 hasAuthorship W3113441794A5087681217 @default.
• W3113441794 hasBestOaLocation W31134417941 @default.
• W3113441794 hasConcept C11960822 @default.
• W3113441794 hasConcept C134018914 @default.

• next