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• W3113444301 abstract "ABSTRACT The mechanism behind transgenerational epigenetic inheritance (TEI) is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr gt hypomorphic mutation results in TEI of congenital malformations. Either maternal grandparent can initiate this phenomenon, which persists for at least four wildtype generations. In this work, we use a genome-wide approach to reveal genetic stability in the Mtrr gt model and epigenome-wide differential DNA methylation in the germline of Mtrr +/gt maternal grandfathers. While epigenetic reprogramming occurs, wildtype grandprogeny and great grandprogeny exhibit transcriptional memory of germline methylation defects. One region encompasses the Hira gene, which is misexpressed in embryos at least until the F3 generation in a manner that distinguishes Hira transcript expression as a biomarker of maternal phenotypic inheritance." @default.
• W3113444301 created "2021-01-05" @default.
• W3113444301 creator A5037115895 @default.
• W3113444301 creator A5037670442 @default.
• W3113444301 creator A5049602911 @default.
• W3113444301 creator A5075317332 @default.
• W3113444301 creator A5079434666 @default.
• W3113444301 creator A5081663735 @default.
• W3113444301 creator A5086644518 @default.
• W3113444301 date "2020-05-25" @default.
• W3113444301 modified "2023-10-18" @default.
• W3113444301 title "Defective folate metabolism causes germline epigenetic instability and distinguishes <i>Hira</i> as a phenotype inheritance biomarker" @default.
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• W3113444301 doi "https://doi.org/10.1101/2020.05.21.109256" @default.
• W3113444301 hasPublicationYear "2020" @default.

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