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- W3113451196 abstract "Non-alcoholic fatty liver disease (NAFLD) is a multi-systemic disease that is considered the hepatic manifestation of metabolic (MetS). Because alcohol consumption in NAFLD patients is common, there is a significant overlap in the pathogenesis of NAFLD and alcoholic liver disease (ALD). Indeed, MetS also significantly contributes to liver injury in ALD patients. This syndrome of metabolic and alcoholic steatohepatitis (SMASH) is thus expected to be a more prevalent presentation in liver patients, as the obesity epidemic continues. Several pre-clinical experimental models that couple alcohol consumption with NAFLD-inducing diet or genetic obesity have been developed to better understand the pathogenic mechanisms of SMASH. These models indicate that concomitant MetS and alcohol contribute to lipid dysregulation, oxidative stress, and the induction of innate immune response. There are significant limitations in the applicability of these models to human disease, such as the ability to induce advanced liver injury or replicate patterns in human food/alcohol consumption. Thus, there remains a need to develop models that accurately replicate patterns of obesogenic diet and alcohol consumption in SMASH patients." @default.
- W3113451196 created "2021-01-05" @default.
- W3113451196 creator A5000962173 @default.
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- W3113451196 creator A5052436998 @default.
- W3113451196 date "2021-01-07" @default.
- W3113451196 modified "2023-10-12" @default.
- W3113451196 title "Experimental models of metabolic and alcoholic fatty liver disease" @default.
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