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- W3113452071 abstract "The objective: was to determine in the urine of patients with calcium-oxalate nephrolithiasis (Ca-Ox NL) and phosphoric acid nephrolithiasis PhAU) and in the rabbit kidney parenchyma with simulated ischemia, the activity of lysosome enzymes N-acetyl-β-D-glucosaminidase (NAG) and β-galactosidase (β-Gal) as enzymatic indicators of the ischemic origin of the kidney parenchyma.Materials and methods. In the urine of 151 patients with nephrolithiasis with preserved renal function (45 with Ca-Ox NL and 106 with PhANL), the activity of the lysosomal enzymes NAG and β-Gal was examined. Patients are divided into groups depending on the type of NL, the size of the calculus and its mineral composition. The reference group – 25 healthy persons. An experimental study was conducted on 10 rabbits with modeled left kidney ischemia, which developed 3.5 to 5.0 months after ligature was applied to its upper pole, and 3 healthy rabbits (6 kidneys). The activity of NAG and β-Gal was determined in the homogenate of the cortical layer of the upper pole of the ischemic kidney and the kidneys of healthy rabbits.Results. All patients with nephrolithiasis have ischemic damage to the kidney parenchyma of varying severity. The most significant ischemic damage to the kidney parenchyma by calculus according to the definition of NAG and β-Gal was recorded in patients with PhANL with magnesium-containing calculi, which had the largest stone sizes. In the experiment on rabbits, a significant decrease in the enzyme activity in the renal parenchyma of animals with ischemia was shown to be compared with similar parameters in healthy rabbits.Conclusion. The results obtained indicate the feasibility of determining the activity of lysosomal enzymes of urine NAG and β-Gal as non-invasive enzyme indicators of ischemic damage to the tubular epithelium of the kidney in patients with nephrolithiasis, which is confirmed by experimental studies. The severity of ischemic damage to the kidney parenchyma in patients with nephrolithiasis according to the determination of the activity of the NAG and β-Gal enzymes in urine depends on the type of nephrolithiasis, the size of the calculus and its mineral composition." @default.
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- W3113452071 date "2020-09-30" @default.
- W3113452071 modified "2023-10-14" @default.
- W3113452071 title "Enzymologic Indicators of Ischemic Damage to the Kidney Parenchyma in Patients with Urolithiasis (Clinical Experimental Study)" @default.
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- W3113452071 doi "https://doi.org/10.30841/2307-5090.3.2020.215938" @default.
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