FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113457554> ?p ?o ?g. }

• W3113457554 abstract "The rise in rates of opioid abuse in recent years has led to an increase in the incidence of neonatal abstinence syndrome (NAS). Despite having a greater understanding of NAS and its symptoms, there still remains a lack of information surrounding the long-term effects of prenatal exposure to drugs of abuse on neurological development. One potential outcome of prenatal drug exposure that has been increasingly explored is disruption in normal synaptogenesis within the central nervous system. Both opioids and gabapentin, an antiepileptic drug commonly co-abused by opioid abuse disorder patients, have been shown to interfere with the normal functioning of astrocytes, non-neuronal glial cells known to serve many functions, including regulation of synaptic development. The goal of this study was to investigate the effects of prenatal drug exposure on synaptogenesis within brain regions associated with the mesolimbic dopamine pathway, the primary reward pathway within the brain associated with drug abuse and addiction, in a pregnant mouse model. Immunohistochemistry (IHC) and confocal fluorescence microscopy imaging studies on the brains of postnatal day 21 (P21) mouse pups revealed a significant increase in the mean number of excitatory synapses within the anterior cingulate cortex (ACC), nucleus accumbens (NAc), and prefrontal cortex (PFC) in mice that were prenatally exposed to either the opioid drug buprenorphine or gabapentin. These studies also revealed a significant decrease in the mean number of inhibitory synapses within the NAc and PFC of mice treated with buprenorphine. This observed net increase in excitatory signaling capability within the developing mesolimbic dopamine pathway suggests that exposure to drugs of abuse in utero can trigger maladaptive neuronal connectivity that persists beyond the earliest stages of life." @default.
• W3113457554 created "2021-01-05" @default.
• W3113457554 creator A5008240997 @default.
• W3113457554 creator A5009238442 @default.
• W3113457554 creator A5028640309 @default.
• W3113457554 creator A5035722529 @default.
• W3113457554 creator A5043887012 @default.
• W3113457554 creator A5052094334 @default.
• W3113457554 date "2020-12-20" @default.
• W3113457554 modified "2023-10-16" @default.
• W3113457554 title "Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure" @default.
• W3113457554 cites W1541267199 @default.
• W3113457554 cites W1768956672 @default.
• W3113457554 cites W1823299575 @default.
• W3113457554 cites W1902878432 @default.
• W3113457554 cites W1965307957 @default.
• W3113457554 cites W1969688763 @default.
• W3113457554 cites W1970581037 @default.
• W3113457554 cites W1973180535 @default.
• W3113457554 cites W1982145810 @default.
• W3113457554 cites W1988452935 @default.
• W3113457554 cites W1994334998 @default.
• W3113457554 cites W1999247756 @default.
• W3113457554 cites W2002865586 @default.
• W3113457554 cites W2005163824 @default.
• W3113457554 cites W2006319531 @default.
• W3113457554 cites W2014285566 @default.
• W3113457554 cites W2021256567 @default.
• W3113457554 cites W2029540523 @default.
• W3113457554 cites W2037048489 @default.
• W3113457554 cites W2041491283 @default.
• W3113457554 cites W2050452462 @default.
• W3113457554 cites W2051001116 @default.
• W3113457554 cites W2060294841 @default.
• W3113457554 cites W2065588791 @default.
• W3113457554 cites W2066735559 @default.
• W3113457554 cites W2069107562 @default.
• W3113457554 cites W2069498125 @default.
• W3113457554 cites W2080994807 @default.
• W3113457554 cites W2082116524 @default.
• W3113457554 cites W2091094596 @default.
• W3113457554 cites W2096120932 @default.
• W3113457554 cites W2098622411 @default.
• W3113457554 cites W2103289578 @default.
• W3113457554 cites W2108470366 @default.
• W3113457554 cites W2109518858 @default.
• W3113457554 cites W2117713721 @default.
• W3113457554 cites W2124147311 @default.
• W3113457554 cites W2125236750 @default.
• W3113457554 cites W2126525449 @default.
• W3113457554 cites W2131701641 @default.
• W3113457554 cites W2145661927 @default.
• W3113457554 cites W2147140183 @default.
• W3113457554 cites W2149354807 @default.
• W3113457554 cites W2160829173 @default.
• W3113457554 cites W2169863475 @default.
• W3113457554 cites W2315398542 @default.
• W3113457554 cites W2340250473 @default.
• W3113457554 cites W2402187732 @default.
• W3113457554 cites W2465910871 @default.
• W3113457554 cites W2550710150 @default.
• W3113457554 cites W2551662476 @default.
• W3113457554 cites W2614373383 @default.
• W3113457554 cites W2614568700 @default.
• W3113457554 cites W2624698999 @default.
• W3113457554 cites W2767960938 @default.
• W3113457554 cites W2771946199 @default.
• W3113457554 cites W2804479495 @default.
• W3113457554 cites W2884522219 @default.
• W3113457554 cites W2897300390 @default.
• W3113457554 cites W2902339732 @default.
• W3113457554 cites W2960111824 @default.
• W3113457554 cites W2965053675 @default.
• W3113457554 cites W3024747692 @default.
• W3113457554 cites W380467884 @default.
• W3113457554 cites W4237857752 @default.
• W3113457554 doi "https://doi.org/10.1101/2020.12.18.423503" @default.
• W3113457554 hasPublicationYear "2020" @default.
• W3113457554 type Work @default.
• W3113457554 sameAs 3113457554 @default.
• W3113457554 citedByCount "0" @default.
• W3113457554 crossrefType "posted-content" @default.
• W3113457554 hasAuthorship W3113457554A5008240997 @default.
• W3113457554 hasAuthorship W3113457554A5009238442 @default.
• W3113457554 hasAuthorship W3113457554A5028640309 @default.
• W3113457554 hasAuthorship W3113457554A5035722529 @default.
• W3113457554 hasAuthorship W3113457554A5043887012 @default.
• W3113457554 hasAuthorship W3113457554A5052094334 @default.
• W3113457554 hasBestOaLocation W31134575541 @default.
• W3113457554 hasConcept C112592302 @default.
• W3113457554 hasConcept C126322002 @default.
• W3113457554 hasConcept C15744967 @default.
• W3113457554 hasConcept C169760540 @default.
• W3113457554 hasConcept C170493617 @default.
• W3113457554 hasConcept C17077164 @default.
• W3113457554 hasConcept C2776552330 @default.
• W3113457554 hasConcept C2781063702 @default.
• W3113457554 hasConcept C513476851 @default.
• W3113457554 hasConcept C65232495 @default.
• W3113457554 hasConcept C71924100 @default.

• next