FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113481410> ?p ?o ?g. }

• W3113481410 endingPage "e0242438" @default.
• W3113481410 startingPage "e0242438" @default.
• W3113481410 abstract "Background Mannose-binding lectin (MBL) plays a pivotal role in innate immunity; however, its impact on susceptibility to opportunistic infections (OIs) has not yet been examined in a natural history cohort of people living with HIV/AIDS. Methods We used archived samples to analyze the association between MBL expression types and risk of major OIs including Pneumocystis jirovecii pneumonia (PCP), cryptococcosis, talaromycosis, toxoplasmosis, and tuberculosis in a prospective cohort in Northern Thailand conducted from 1 July 2000 to 15 October 2002 before the national antiretroviral treatment programme was launched. Results Of 632 patients, PCP was diagnosed in 96 (15.2%) patients, including 45 patients with new episodes during the follow-up period (1006.5 person-years). The total history of PCP was significantly associated with low MBL expression type: high/intermediate (81/587, 13.8%), low (10/33, 30.3%) and deficient (5/12, 41.7%) (p = 0.001), whereas the history of other OIs showed no relation with any MBL expression type. Kaplan–Meier analysis (n = 569; log-rank p = 0.011) and Cox’s proportional hazards model revealed that deficient genotype dramatically increased the risk of PCP, which is independent upon sex, age, CD4 count, HIV-1 viral load and hepatitis B and C status (adjusted hazard ratio 7.93, 95% confidence interval 2.19–28.67, p = 0.002). Conclusions Deficiency of MBL expression is a strong risk factor determining the incidence of PCP but not other major OIs." @default.
• W3113481410 created "2021-01-05" @default.
• W3113481410 creator A5001652900 @default.
• W3113481410 creator A5013384188 @default.
• W3113481410 creator A5020240225 @default.
• W3113481410 creator A5023380184 @default.
• W3113481410 creator A5029410915 @default.
• W3113481410 creator A5030434012 @default.
• W3113481410 creator A5043810156 @default.
• W3113481410 creator A5049851204 @default.
• W3113481410 creator A5050969230 @default.
• W3113481410 creator A5066174292 @default.
• W3113481410 creator A5080463718 @default.
• W3113481410 creator A5086146977 @default.
• W3113481410 date "2020-12-23" @default.
• W3113481410 modified "2023-10-12" @default.
• W3113481410 title "Deficiency of mannose-binding lectin is a risk of Pneumocystis jirovecii pneumonia in a natural history cohort of people living with HIV/AIDS in Northern Thailand" @default.
• W3113481410 cites W1986908601 @default.
• W3113481410 cites W1996814765 @default.
• W3113481410 cites W1996828461 @default.
• W3113481410 cites W2002836781 @default.
• W3113481410 cites W2007334511 @default.
• W3113481410 cites W2011846108 @default.
• W3113481410 cites W2013618140 @default.
• W3113481410 cites W2017994045 @default.
• W3113481410 cites W2021616340 @default.
• W3113481410 cites W2051072385 @default.
• W3113481410 cites W2057578063 @default.
• W3113481410 cites W2070412644 @default.
• W3113481410 cites W2070483149 @default.
• W3113481410 cites W2073193013 @default.
• W3113481410 cites W2080323385 @default.
• W3113481410 cites W2088274155 @default.
• W3113481410 cites W2100967062 @default.
• W3113481410 cites W2109499228 @default.
• W3113481410 cites W2109754026 @default.
• W3113481410 cites W2111345804 @default.
• W3113481410 cites W2126368931 @default.
• W3113481410 cites W2133543557 @default.
• W3113481410 cites W2171000821 @default.
• W3113481410 cites W2346679109 @default.
• W3113481410 cites W2532435486 @default.
• W3113481410 cites W2609362251 @default.
• W3113481410 cites W2733732621 @default.
• W3113481410 cites W2790006576 @default.
• W3113481410 cites W2803328907 @default.
• W3113481410 cites W2949087121 @default.
• W3113481410 cites W2952977999 @default.
• W3113481410 doi "https://doi.org/10.1371/journal.pone.0242438" @default.
• W3113481410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7757797" @default.
• W3113481410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33362211" @default.
• W3113481410 hasPublicationYear "2020" @default.
• W3113481410 type Work @default.
• W3113481410 sameAs 3113481410 @default.
• W3113481410 citedByCount "5" @default.
• W3113481410 countsByYear W31134814102021 @default.
• W3113481410 countsByYear W31134814102022 @default.
• W3113481410 crossrefType "journal-article" @default.
• W3113481410 hasAuthorship W3113481410A5001652900 @default.
• W3113481410 hasAuthorship W3113481410A5013384188 @default.
• W3113481410 hasAuthorship W3113481410A5020240225 @default.
• W3113481410 hasAuthorship W3113481410A5023380184 @default.
• W3113481410 hasAuthorship W3113481410A5029410915 @default.
• W3113481410 hasAuthorship W3113481410A5030434012 @default.
• W3113481410 hasAuthorship W3113481410A5043810156 @default.
• W3113481410 hasAuthorship W3113481410A5049851204 @default.
• W3113481410 hasAuthorship W3113481410A5050969230 @default.
• W3113481410 hasAuthorship W3113481410A5066174292 @default.
• W3113481410 hasAuthorship W3113481410A5080463718 @default.
• W3113481410 hasAuthorship W3113481410A5086146977 @default.
• W3113481410 hasBestOaLocation W31134814101 @default.
• W3113481410 hasConcept C126322002 @default.
• W3113481410 hasConcept C189413060 @default.
• W3113481410 hasConcept C203014093 @default.
• W3113481410 hasConcept C207103383 @default.
• W3113481410 hasConcept C2776391196 @default.
• W3113481410 hasConcept C2777160144 @default.
• W3113481410 hasConcept C2777559004 @default.
• W3113481410 hasConcept C2777914695 @default.
• W3113481410 hasConcept C2780758401 @default.
• W3113481410 hasConcept C44249647 @default.
• W3113481410 hasConcept C50382708 @default.
• W3113481410 hasConcept C50440223 @default.
• W3113481410 hasConcept C71924100 @default.
• W3113481410 hasConcept C72563966 @default.
• W3113481410 hasConceptScore W3113481410C126322002 @default.
• W3113481410 hasConceptScore W3113481410C189413060 @default.
• W3113481410 hasConceptScore W3113481410C203014093 @default.
• W3113481410 hasConceptScore W3113481410C207103383 @default.
• W3113481410 hasConceptScore W3113481410C2776391196 @default.
• W3113481410 hasConceptScore W3113481410C2777160144 @default.
• W3113481410 hasConceptScore W3113481410C2777559004 @default.
• W3113481410 hasConceptScore W3113481410C2777914695 @default.
• W3113481410 hasConceptScore W3113481410C2780758401 @default.
• W3113481410 hasConceptScore W3113481410C44249647 @default.
• W3113481410 hasConceptScore W3113481410C50382708 @default.
• W3113481410 hasConceptScore W3113481410C50440223 @default.
• W3113481410 hasConceptScore W3113481410C71924100 @default.

• next