Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113482979> ?p ?o ?g. }
- W3113482979 abstract "ABSTRACT Both symbiotic and pathogenic bacteria in the family Coxiellaceae cause morbidity and mortality in humans and animals. For instance, Coxiella -like endosymbionts (CLEs) improve the reproductive success of ticks — a major disease vector, while Coxiella burnetii is the etiological agent of human Q fever and uncharacterized coxiellae cause infections in both animals and humans. To better understand the evolution of pathogenesis and symbiosis in this group of intracellular bacteria, we sequenced the genome of a CLE present in the soft tick Ornithodoros amblus (CLEOA) and compared it to the genomes of other bacteria in the order Legionellales. Our analyses confirmed that CLEOA is more closely related to C. burnetii , the human pathogen, than to CLEs in hard ticks, and showed that most clades of CLEs contain both endosymbionts and pathogens, indicating that several CLE lineages have evolved independently from pathogenic Coxiella . We also determined that the last common ancestor of CLEOA and C. burnetii was equipped to infect macrophages, and that even though HGT contributed significantly to the evolution of C. burnetii , most acquisition events occurred primarily in ancestors predating the CLEOA- C. burnetii divergence. These discoveries clarify the evolution of C. burnetii , which previously was assumed to have emerged when an avirulent tick endosymbiont recently gained virulence factors via HGT. Finally, we identified several metabolic pathways, including heme biosynthesis, that are likely critical to the intracellular growth of the human pathogen but not the tick symbiont, and show that the use of heme analogs is a promising approach to controlling C. burnetii infections." @default.
- W3113482979 created "2021-01-05" @default.
- W3113482979 creator A5003773834 @default.
- W3113482979 creator A5011799896 @default.
- W3113482979 creator A5023239631 @default.
- W3113482979 creator A5041027530 @default.
- W3113482979 creator A5058741642 @default.
- W3113482979 date "2020-12-30" @default.
- W3113482979 modified "2023-10-18" @default.
- W3113482979 title "Ticks convert pathogenicCoxiellainto endosymbionts" @default.
- W3113482979 cites W104710838 @default.
- W3113482979 cites W1511429670 @default.
- W3113482979 cites W1528915427 @default.
- W3113482979 cites W162750041 @default.
- W3113482979 cites W1900937478 @default.
- W3113482979 cites W1952712068 @default.
- W3113482979 cites W1953716282 @default.
- W3113482979 cites W1966026670 @default.
- W3113482979 cites W1968179480 @default.
- W3113482979 cites W1969042907 @default.
- W3113482979 cites W1969930250 @default.
- W3113482979 cites W1976841360 @default.
- W3113482979 cites W1979586627 @default.
- W3113482979 cites W1997729188 @default.
- W3113482979 cites W2001881923 @default.
- W3113482979 cites W2012783678 @default.
- W3113482979 cites W2018590530 @default.
- W3113482979 cites W2023491792 @default.
- W3113482979 cites W2024471195 @default.
- W3113482979 cites W2028133510 @default.
- W3113482979 cites W2033032476 @default.
- W3113482979 cites W2034036140 @default.
- W3113482979 cites W2045843097 @default.
- W3113482979 cites W2053750442 @default.
- W3113482979 cites W2059536794 @default.
- W3113482979 cites W2062418171 @default.
- W3113482979 cites W2063015476 @default.
- W3113482979 cites W2071327034 @default.
- W3113482979 cites W2076219800 @default.
- W3113482979 cites W2080229897 @default.
- W3113482979 cites W2089468702 @default.
- W3113482979 cites W2089859322 @default.
- W3113482979 cites W2092604303 @default.
- W3113482979 cites W2093172628 @default.
- W3113482979 cites W2102586400 @default.
- W3113482979 cites W2103370720 @default.
- W3113482979 cites W2103901746 @default.
- W3113482979 cites W2104436823 @default.
- W3113482979 cites W2104515939 @default.
- W3113482979 cites W2109113001 @default.
- W3113482979 cites W2109122955 @default.
- W3113482979 cites W2109336572 @default.
- W3113482979 cites W2113824405 @default.
- W3113482979 cites W2113997222 @default.
- W3113482979 cites W2115228331 @default.
- W3113482979 cites W2118113449 @default.
- W3113482979 cites W2119979039 @default.
- W3113482979 cites W2125102767 @default.
- W3113482979 cites W2125310261 @default.
- W3113482979 cites W2131271579 @default.
- W3113482979 cites W2132020588 @default.
- W3113482979 cites W2136328284 @default.
- W3113482979 cites W2137073017 @default.
- W3113482979 cites W2138952930 @default.
- W3113482979 cites W2141052558 @default.
- W3113482979 cites W2141767195 @default.
- W3113482979 cites W2143485490 @default.
- W3113482979 cites W2143537846 @default.
- W3113482979 cites W2146472203 @default.
- W3113482979 cites W2147838321 @default.
- W3113482979 cites W2148698435 @default.
- W3113482979 cites W2150373302 @default.
- W3113482979 cites W2152673694 @default.
- W3113482979 cites W2156406147 @default.
- W3113482979 cites W2157067275 @default.
- W3113482979 cites W2159584927 @default.
- W3113482979 cites W2159957100 @default.
- W3113482979 cites W2160378127 @default.
- W3113482979 cites W2169289641 @default.
- W3113482979 cites W2233266378 @default.
- W3113482979 cites W2233407458 @default.
- W3113482979 cites W2281768771 @default.
- W3113482979 cites W2330790086 @default.
- W3113482979 cites W2339057086 @default.
- W3113482979 cites W2409569983 @default.
- W3113482979 cites W2440598235 @default.
- W3113482979 cites W2521747717 @default.
- W3113482979 cites W2554655922 @default.
- W3113482979 cites W2591599064 @default.
- W3113482979 cites W2599417231 @default.
- W3113482979 cites W2605399537 @default.
- W3113482979 cites W2613514354 @default.
- W3113482979 cites W2619167181 @default.
- W3113482979 cites W2745954723 @default.
- W3113482979 cites W2772583830 @default.
- W3113482979 cites W2773308838 @default.
- W3113482979 cites W2789707100 @default.
- W3113482979 cites W2789741824 @default.
- W3113482979 cites W2790049812 @default.
- W3113482979 cites W2790398905 @default.