FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113485666> ?p ?o ?g. }

• W3113485666 endingPage "10" @default.
• W3113485666 startingPage "1" @default.
• W3113485666 abstract "Background and Aim. Numerous reports have indicated that dealing with stressors in life is a main risk factor for the occurrence and progression of cognitive and memory impairment. Available treatments such as benzodiazepine and antidepressants address only certain aspects of this stress disorder and have numerous side effects. The present study was aimed at investigating the effect of diosmetin, as a flavonoid compound with potent antioxidant and anti-inflammatory effects, on cognitive impairment and chronic stress memory. Materials and Methods. In the present experimental study, male NMRI mice were exposed to chronic unpredictable mild stress (CUMS) paradigm for 35 days. Diosmetin (at doses of 10, 20, and 40 mg/kg. i.p.) or diosmetin solvent (normal saline + DMSO, 1 ml/kg; i.p.) was administered 30 min before stress induction. After 28 days, memory and cognitive performance were assessed by shuttle box and novel object recognition tests. Finally, antioxidant capacity (FRAP) and malondialdehyde (MDA) level of serum and brain, and serum corticosterone level were evaluated. Results. Behavioral tests showed that CUMS significantly reduced the secondary latency in passive avoidance memory test and diagnosis index in novel object recognition test compared to the control group ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ), whereas treatment with diosmetin (20 and 40 mg/kg) significantly improved memory performance in the two tests ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ). In addition, diosmetin (40 mg/kg) could pronouncedly suppress increase in serum corticosterone levels, reduction in antioxidant capacity, and production of excess MDA caused by CUMS compared to the control group ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> , and <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> , respectively). Conclusion. Chronic stress can impair memory and cognition and treatment with diosmetin can partly improve this disorder in male mice by increasing the antioxidant capacity of brain tissue and serum and improving serum corticosterone levels." @default.
• W3113485666 created "2021-01-05" @default.
• W3113485666 creator A5039405347 @default.
• W3113485666 creator A5041220796 @default.
• W3113485666 creator A5049658237 @default.
• W3113485666 creator A5059100518 @default.
• W3113485666 creator A5064130502 @default.
• W3113485666 date "2020-12-21" @default.
• W3113485666 modified "2023-09-26" @default.
• W3113485666 title "Diosmetin Mitigates Cognitive and Memory Impairment Provoked by Chronic Unpredictable Mild Stress in Mice" @default.
• W3113485666 cites W1133079448 @default.
• W3113485666 cites W1963820036 @default.
• W3113485666 cites W1967840782 @default.
• W3113485666 cites W1972289338 @default.
• W3113485666 cites W1973840046 @default.
• W3113485666 cites W1975189679 @default.
• W3113485666 cites W1975692706 @default.
• W3113485666 cites W1978235424 @default.
• W3113485666 cites W1985940694 @default.
• W3113485666 cites W1992451200 @default.
• W3113485666 cites W1996499700 @default.
• W3113485666 cites W2001646460 @default.
• W3113485666 cites W2020788145 @default.
• W3113485666 cites W2022008604 @default.
• W3113485666 cites W2032970619 @default.
• W3113485666 cites W2040149516 @default.
• W3113485666 cites W2050836998 @default.
• W3113485666 cites W2057752710 @default.
• W3113485666 cites W2066988573 @default.
• W3113485666 cites W2072441360 @default.
• W3113485666 cites W2072869405 @default.
• W3113485666 cites W2077763928 @default.
• W3113485666 cites W2078920384 @default.
• W3113485666 cites W2080009814 @default.
• W3113485666 cites W2094775089 @default.
• W3113485666 cites W2097820520 @default.
• W3113485666 cites W2111408945 @default.
• W3113485666 cites W2112354679 @default.
• W3113485666 cites W2118136637 @default.
• W3113485666 cites W2120279490 @default.
• W3113485666 cites W2125726852 @default.
• W3113485666 cites W2128761870 @default.
• W3113485666 cites W2138681644 @default.
• W3113485666 cites W2146181702 @default.
• W3113485666 cites W2160729076 @default.
• W3113485666 cites W2198360126 @default.
• W3113485666 cites W2212768539 @default.
• W3113485666 cites W2311108699 @default.
• W3113485666 cites W2316654105 @default.
• W3113485666 cites W2330192046 @default.
• W3113485666 cites W2513070970 @default.
• W3113485666 cites W2547543126 @default.
• W3113485666 cites W2590525849 @default.
• W3113485666 cites W2738176447 @default.
• W3113485666 cites W2759969248 @default.
• W3113485666 cites W2767234884 @default.
• W3113485666 doi "https://doi.org/10.1155/2020/5725361" @default.
• W3113485666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7769643" @default.
• W3113485666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33414836" @default.
• W3113485666 hasPublicationYear "2020" @default.
• W3113485666 type Work @default.
• W3113485666 sameAs 3113485666 @default.
• W3113485666 citedByCount "8" @default.
• W3113485666 countsByYear W31134856662021 @default.
• W3113485666 countsByYear W31134856662022 @default.
• W3113485666 countsByYear W31134856662023 @default.
• W3113485666 crossrefType "journal-article" @default.
• W3113485666 hasAuthorship W3113485666A5039405347 @default.
• W3113485666 hasAuthorship W3113485666A5041220796 @default.
• W3113485666 hasAuthorship W3113485666A5049658237 @default.
• W3113485666 hasAuthorship W3113485666A5059100518 @default.
• W3113485666 hasAuthorship W3113485666A5064130502 @default.
• W3113485666 hasBestOaLocation W31134856661 @default.
• W3113485666 hasConcept C126322002 @default.
• W3113485666 hasConcept C136569192 @default.
• W3113485666 hasConcept C15744967 @default.
• W3113485666 hasConcept C169760540 @default.
• W3113485666 hasConcept C169900460 @default.
• W3113485666 hasConcept C185711340 @default.
• W3113485666 hasConcept C2776151105 @default.
• W3113485666 hasConcept C2778401633 @default.
• W3113485666 hasConcept C2778654844 @default.
• W3113485666 hasConcept C2779177272 @default.
• W3113485666 hasConcept C2780352252 @default.
• W3113485666 hasConcept C2780749935 @default.
• W3113485666 hasConcept C2781161787 @default.
• W3113485666 hasConcept C2984915365 @default.
• W3113485666 hasConcept C3018842126 @default.
• W3113485666 hasConcept C71315377 @default.
• W3113485666 hasConcept C71924100 @default.
• W3113485666 hasConcept C98274493 @default.
• W3113485666 hasConceptScore W3113485666C126322002 @default.
• W3113485666 hasConceptScore W3113485666C136569192 @default.
• W3113485666 hasConceptScore W3113485666C15744967 @default.
• W3113485666 hasConceptScore W3113485666C169760540 @default.
• W3113485666 hasConceptScore W3113485666C169900460 @default.
• W3113485666 hasConceptScore W3113485666C185711340 @default.
• W3113485666 hasConceptScore W3113485666C2776151105 @default.

• next