FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113649924> ?p ?o ?g. }

• W3113649924 endingPage "463" @default.
• W3113649924 startingPage "452" @default.
• W3113649924 abstract "Summary Autoimmune diseases are caused by adaptive immune responses to self‐antigens. The development of antigen‐specific therapies that suppress disease‐related, but not unrelated immune responses in general, is an important goal of biomedical research. We have previously shown that delivery of myelin peptides to liver sinusoidal endothelial cells (LSECs) using LSEC‐targeting nanoparticles provides effective protection from CD4 T‐cell‐driven autoimmune encephalomyelitis. Here, we investigated whether this methodology might also serve antigen‐specific treatment of a CD8 T‐cell‐driven autoimmune disease. As a model for CD8 T‐cell‐mediated autoimmunity, we used OT‐1 T‐cell‐driven cholangitis in K14‐OVAp mice expressing the cognate MHC I‐restricted SIINFEKL peptide in cholangiocytes. To study whether peptide delivery to LSECs could modulate cholangitis, SIINFEKL peptide‐conjugated nanoparticles were administered intravenously one day before transfer of OT‐1 T cells; five days after cell transfer, liver pathology and hepatic infiltrates were analysed. SIINFEKL peptide‐conjugated nanoparticles were rapidly taken up by LSECs in vivo, which effectively cross‐presented the delivered peptide on MHC I molecules. Intriguingly, K14‐OVAp mice receiving SIINFEKL‐loaded nanoparticles manifested significantly reduced liver damage compared with vehicle‐treated K14‐OVAp mice. Mechanistically, treatment with LSEC‐targeting SIINFEKL‐loaded nanoparticles significantly reduced the number of liver‐infiltrating OT‐1 T cells, which up‐regulated expression of the co‐inhibitory receptor PD‐1 and down‐regulated cytotoxic effector function and inflammatory cytokine production. These findings show that tolerogenic LSECs can effectively internalize circulating nanoparticles and cross‐present nanoparticle‐bound peptides on MHC I molecules. Therefore, nanoparticle‐mediated autoantigen peptide delivery to LSECs might serve the antigen‐specific treatment of CD8 T‐cell‐driven autoimmune disease." @default.
• W3113649924 created "2021-01-05" @default.
• W3113649924 creator A5005653232 @default.
• W3113649924 creator A5006405204 @default.
• W3113649924 creator A5007012421 @default.
• W3113649924 creator A5008083146 @default.
• W3113649924 creator A5009919053 @default.
• W3113649924 creator A5017251582 @default.
• W3113649924 creator A5027709307 @default.
• W3113649924 creator A5041950783 @default.
• W3113649924 creator A5050051944 @default.
• W3113649924 creator A5059823097 @default.
• W3113649924 creator A5064823028 @default.
• W3113649924 creator A5067911784 @default.
• W3113649924 creator A5073186893 @default.
• W3113649924 creator A5088718716 @default.
• W3113649924 date "2021-01-07" @default.
• W3113649924 modified "2023-10-18" @default.
• W3113649924 title "Nanoparticle‐mediated targeting of autoantigen peptide to cross‐presenting liver sinusoidal endothelial cells protects from CD8 T‐cell‐driven autoimmune cholangitis" @default.
• W3113649924 cites W1490345525 @default.
• W3113649924 cites W1498929362 @default.
• W3113649924 cites W1802912856 @default.
• W3113649924 cites W1965296830 @default.
• W3113649924 cites W1977402753 @default.
• W3113649924 cites W1978684572 @default.
• W3113649924 cites W1980906108 @default.
• W3113649924 cites W2001656273 @default.
• W3113649924 cites W2010738373 @default.
• W3113649924 cites W2023244011 @default.
• W3113649924 cites W2029704355 @default.
• W3113649924 cites W2056815530 @default.
• W3113649924 cites W2066352983 @default.
• W3113649924 cites W2081212861 @default.
• W3113649924 cites W2090427489 @default.
• W3113649924 cites W2095405069 @default.
• W3113649924 cites W2096102838 @default.
• W3113649924 cites W2112700181 @default.
• W3113649924 cites W2120488011 @default.
• W3113649924 cites W2122537990 @default.
• W3113649924 cites W2126522707 @default.
• W3113649924 cites W2164779038 @default.
• W3113649924 cites W2220984925 @default.
• W3113649924 cites W2316973802 @default.
• W3113649924 cites W2335877122 @default.
• W3113649924 cites W2504151231 @default.
• W3113649924 cites W255554239 @default.
• W3113649924 cites W2775438937 @default.
• W3113649924 cites W2792383348 @default.
• W3113649924 cites W2897020726 @default.
• W3113649924 cites W2903645751 @default.
• W3113649924 cites W4242768823 @default.
• W3113649924 doi "https://doi.org/10.1111/imm.13298" @default.
• W3113649924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7968394" @default.
• W3113649924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33346377" @default.
• W3113649924 hasPublicationYear "2021" @default.
• W3113649924 type Work @default.
• W3113649924 sameAs 3113649924 @default.
• W3113649924 citedByCount "11" @default.
• W3113649924 countsByYear W31136499242021 @default.
• W3113649924 countsByYear W31136499242022 @default.
• W3113649924 countsByYear W31136499242023 @default.
• W3113649924 crossrefType "journal-article" @default.
• W3113649924 hasAuthorship W3113649924A5005653232 @default.
• W3113649924 hasAuthorship W3113649924A5006405204 @default.
• W3113649924 hasAuthorship W3113649924A5007012421 @default.
• W3113649924 hasAuthorship W3113649924A5008083146 @default.
• W3113649924 hasAuthorship W3113649924A5009919053 @default.
• W3113649924 hasAuthorship W3113649924A5017251582 @default.
• W3113649924 hasAuthorship W3113649924A5027709307 @default.
• W3113649924 hasAuthorship W3113649924A5041950783 @default.
• W3113649924 hasAuthorship W3113649924A5050051944 @default.
• W3113649924 hasAuthorship W3113649924A5059823097 @default.
• W3113649924 hasAuthorship W3113649924A5064823028 @default.
• W3113649924 hasAuthorship W3113649924A5067911784 @default.
• W3113649924 hasAuthorship W3113649924A5073186893 @default.
• W3113649924 hasAuthorship W3113649924A5088718716 @default.
• W3113649924 hasBestOaLocation W31136499241 @default.
• W3113649924 hasConcept C147483822 @default.
• W3113649924 hasConcept C154317977 @default.
• W3113649924 hasConcept C167672396 @default.
• W3113649924 hasConcept C185592680 @default.
• W3113649924 hasConcept C19317047 @default.
• W3113649924 hasConcept C202751555 @default.
• W3113649924 hasConcept C203014093 @default.
• W3113649924 hasConcept C2776090121 @default.
• W3113649924 hasConcept C502942594 @default.
• W3113649924 hasConcept C55493867 @default.
• W3113649924 hasConcept C86803240 @default.
• W3113649924 hasConcept C8891405 @default.
• W3113649924 hasConcept C90375314 @default.
• W3113649924 hasConcept C95444343 @default.
• W3113649924 hasConceptScore W3113649924C147483822 @default.
• W3113649924 hasConceptScore W3113649924C154317977 @default.
• W3113649924 hasConceptScore W3113649924C167672396 @default.
• W3113649924 hasConceptScore W3113649924C185592680 @default.
• W3113649924 hasConceptScore W3113649924C19317047 @default.
• W3113649924 hasConceptScore W3113649924C202751555 @default.
• W3113649924 hasConceptScore W3113649924C203014093 @default.

• next