FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113714094> ?p ?o ?g. }

• W3113714094 endingPage "212" @default.
• W3113714094 startingPage "210" @default.
• W3113714094 abstract "Elevated lipoprotein(a) [Lp(a)] concentrations in blood represent a causal risk factor for cardiovascular diseases [ [1] Nordestgaard B.G. Langsted A. Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology. J. Lipid Res. 2016; 57: 1953-1975 Abstract Full Text Full Text PDF PubMed Scopus (213) Google Scholar ]. The underlying pathogenic mechanisms are not yet fully clarified. Although several studies have shown that Lp(a) contributes to artherosclerosis, it is still uncertain whether or not Lp(a) is involved as a prothrombotic factor [ [2] Boffa M.B. Koschinsky M.L. Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?. J. Lipid Res. 2016; 57: 745-757 Abstract Full Text Full Text PDF PubMed Scopus (109) Google Scholar ]. There is firm biochemical evidence that Lp(a), due to the similarity between apolipoprotein(a) [apo(a)] and plasminogen, inhibits fibrinolysis. However, it remains unknown whether this inhibitory effect is sufficiently strong to play a significant role in the global fibrinolytic activity of the circulating blood that depends on many hemostatic factors. We reviewed the literature and selected only papers with fibrinolysis tests in whole blood or whole plasma. Several studies were unable to demonstrate an association between Lp(a) concentration and fibrinolysis in blood samples from different individuals [ 3 Halvorsen S. Skjonsberg O.H. Berg K. Ruyter R. Godal H.C. Does Lp(a) lipoprotein inhibit the fibrinolytic system?. Thromb. Res. 1992; 68: 223-232 Abstract Full Text PDF PubMed Scopus (27) Google Scholar , 4 Mansson M. Kalies I. Bergstrom G. Schmidt C. Legnehed A. Hulten L.M. et al. Lp(a) is not associated with diabetes but affects fibrinolysis and clot structure ex vivo. Sci. Rep. 2014; 4: 5318 Crossref PubMed Scopus (7) Google Scholar , 5 Skuza A.A. Polak M. Undas A. Elevated lipoprotein(a) as a new risk factor of cerebral venous sinus thrombosis: association with fibrin clot properties. J. Thromb. Thrombolysis. 2019; 47: 8-15 Crossref PubMed Scopus (3) Google Scholar , 6 Stegnar M. Ambrozic J. Berger B. Keber I. In-vitro plasma and euglobulin clot lysis in subjects with elevated lipoprotein(a). Fibrinolysis. 1995; 9: 304-308 Crossref Scopus (7) Google Scholar , 7 Terres W. Krewitt M. Hamm C.W. Effects of lipoprotein(a) on in vitro lysis of whole blood thrombi from healthy volunteers. Thromb. Res. 1993; 69: 479-487 Abstract Full Text PDF PubMed Scopus (14) Google Scholar ] whereas other studies reported a strong association [ 8 Rowland C.M. Pullinger C.R. Luke M.M. Shiffman D. Green L. Movsesyan I. et al. Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties. Thromb. Res. 2014; 133: 863-867 Abstract Full Text Full Text PDF PubMed Scopus (19) Google Scholar , 9 Undas A. Ciesla-Dul M. Drazkiewicz T. Sadowski J. Altered fibrin clot properties are associated with residual vein obstruction: effects of lipoprotein(a) and apolipoprotein(a) isoform. Thromb. Res. 2012; 130: e184-e187 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar , 10 Undas A. Plicner D. Stepien E. Drwila R. Sadowski J. Altered fibrin clot structure in patients with advanced coronary artery disease: a role of C-reactive protein, lipoprotein(a) and homocysteine. J. Thromb. Haemost. 2007; 5: 1988-1990 Crossref PubMed Scopus (65) Google Scholar , 11 Undas A. Stepien E. Tracz W. Szczeklik A. Lipoprotein(a) as a modifier of fibrin clot permeability and susceptibility to lysis. J. Thromb. Haemost. 2006; 4: 973-975 Crossref PubMed Scopus (55) Google Scholar ]. The cause of this apparent discrepancy is unknown. It is striking that the latter studies all utilized a plasma clot lysis assay with an exceptionally high exogenous tissue-type plasminogen activator (tPA) concentration (500 ng/mL) to induce clot lysis. The goal of the present study was to re-examine the association of Lp(a) concentration and global fibrinolytic activity in plasma and blood from individuals with low to high concentrations of Lp(a) by using different clot lysis assays, including assays with high tPA concentrations." @default.
• W3113714094 created "2021-01-05" @default.
• W3113714094 creator A5013184731 @default.
• W3113714094 creator A5035254428 @default.
• W3113714094 creator A5035449921 @default.
• W3113714094 creator A5036018606 @default.
• W3113714094 creator A5045683286 @default.
• W3113714094 creator A5050153201 @default.
• W3113714094 creator A5060363736 @default.
• W3113714094 creator A5065703606 @default.
• W3113714094 creator A5065898515 @default.
• W3113714094 creator A5084233931 @default.
• W3113714094 date "2021-02-01" @default.
• W3113714094 modified "2023-09-26" @default.
• W3113714094 title "How significant is the antifibrinolytic effect of lipoprotein(a) for blood clot lysis?" @default.
• W3113714094 cites W147868144 @default.
• W3113714094 cites W1526544241 @default.
• W3113714094 cites W1993115785 @default.
• W3113714094 cites W2044215790 @default.
• W3113714094 cites W2051733378 @default.
• W3113714094 cites W2073466768 @default.
• W3113714094 cites W2147696440 @default.
• W3113714094 cites W2152398611 @default.
• W3113714094 cites W2153252156 @default.
• W3113714094 cites W2156795909 @default.
• W3113714094 cites W2233281615 @default.
• W3113714094 cites W2234206893 @default.
• W3113714094 cites W2409571813 @default.
• W3113714094 cites W2526556731 @default.
• W3113714094 cites W2602083142 @default.
• W3113714094 cites W2902743227 @default.
• W3113714094 cites W2976623184 @default.
• W3113714094 doi "https://doi.org/10.1016/j.thromres.2020.12.014" @default.
• W3113714094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33373926" @default.
• W3113714094 hasPublicationYear "2021" @default.
• W3113714094 type Work @default.
• W3113714094 sameAs 3113714094 @default.
• W3113714094 citedByCount "4" @default.
• W3113714094 countsByYear W31137140942022 @default.
• W3113714094 countsByYear W31137140942023 @default.
• W3113714094 crossrefType "journal-article" @default.
• W3113714094 hasAuthorship W3113714094A5013184731 @default.
• W3113714094 hasAuthorship W3113714094A5035254428 @default.
• W3113714094 hasAuthorship W3113714094A5035449921 @default.
• W3113714094 hasAuthorship W3113714094A5036018606 @default.
• W3113714094 hasAuthorship W3113714094A5045683286 @default.
• W3113714094 hasAuthorship W3113714094A5050153201 @default.
• W3113714094 hasAuthorship W3113714094A5060363736 @default.
• W3113714094 hasAuthorship W3113714094A5065703606 @default.
• W3113714094 hasAuthorship W3113714094A5065898515 @default.
• W3113714094 hasAuthorship W3113714094A5084233931 @default.
• W3113714094 hasConcept C126322002 @default.
• W3113714094 hasConcept C134018914 @default.
• W3113714094 hasConcept C203014093 @default.
• W3113714094 hasConcept C2776104379 @default.
• W3113714094 hasConcept C2776825266 @default.
• W3113714094 hasConcept C2778163477 @default.
• W3113714094 hasConcept C2780072125 @default.
• W3113714094 hasConcept C62746215 @default.
• W3113714094 hasConcept C71924100 @default.
• W3113714094 hasConceptScore W3113714094C126322002 @default.
• W3113714094 hasConceptScore W3113714094C134018914 @default.
• W3113714094 hasConceptScore W3113714094C203014093 @default.
• W3113714094 hasConceptScore W3113714094C2776104379 @default.
• W3113714094 hasConceptScore W3113714094C2776825266 @default.
• W3113714094 hasConceptScore W3113714094C2778163477 @default.
• W3113714094 hasConceptScore W3113714094C2780072125 @default.
• W3113714094 hasConceptScore W3113714094C62746215 @default.
• W3113714094 hasConceptScore W3113714094C71924100 @default.
• W3113714094 hasLocation W31137140941 @default.
• W3113714094 hasOpenAccess W3113714094 @default.
• W3113714094 hasPrimaryLocation W31137140941 @default.
• W3113714094 hasRelatedWork W1981345773 @default.
• W3113714094 hasRelatedWork W1993860810 @default.
• W3113714094 hasRelatedWork W1999568358 @default.
• W3113714094 hasRelatedWork W2005812619 @default.
• W3113714094 hasRelatedWork W2025648868 @default.
• W3113714094 hasRelatedWork W2033921535 @default.
• W3113714094 hasRelatedWork W2071717752 @default.
• W3113714094 hasRelatedWork W2073466768 @default.
• W3113714094 hasRelatedWork W2090875163 @default.
• W3113714094 hasRelatedWork W2495016602 @default.
• W3113714094 hasVolume "198" @default.
• W3113714094 isParatext "false" @default.
• W3113714094 isRetracted "false" @default.
• W3113714094 magId "3113714094" @default.
• W3113714094 workType "article" @default.