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- W3113723146 abstract "Despite recent advances in therapy, liver metastasis from melanoma is still associated with poor prognosis. Although targeting the mTOR signaling pathway exerts potent anti-tumor activity, little is known about specific mTORC2 inhibition regarding liver metastasis. Using the novel mTORC2 specific inhibitor JR-AB2-011, we show significantly reduced migration and invasion capacity by impaired activation of MMP2 in melanoma cells. In addition, blockade of mTORC2 induces cell death by non-apoptotic pathways and reduces tumor cell proliferation rate dose-dependently. Furthermore, a significant reduction of liver metastasis was detected in a syngeneic murine metastasis model upon therapy with JR-AB2-011 as determined by in vivo imaging and necropsy. Hence, our study for the first time highlights the impact of the pharmacological blockade of mTORC2 as a potent novel anti-cancer approach for liver metastasis from melanoma." @default.
- W3113723146 created "2021-01-05" @default.
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- W3113723146 date "2020-12-22" @default.
- W3113723146 modified "2023-10-14" @default.
- W3113723146 title "Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma" @default.
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- W3113723146 doi "https://doi.org/10.3390/ijms22010030" @default.
- W3113723146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7792954" @default.
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