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- W3113827086 abstract "Since its discovery, the dopamine D4 receptor (D4R) has been suggested to be an attractive target for the treatment of neuropsychiatric diseases. Novel findings have renewed the interest in such a receptor as an emerging target for the management of different diseases, including cancer, Parkinson’s disease, alcohol or substance use disorders, eating disorders, erectile dysfunction and cognitive deficits. The recently resolved crystal structures of D4R in complexes with the potent ligands nemonapride and L-745870 strongly improved the knowledge on the molecular mechanisms involving the D4R functions and may help medicinal chemists in drug design. This review is focused on the recent development of the subtype selective D4R ligands belonging to classical or new chemotypes. Moreover, ligands showing functional selectivity toward G protein activation or β-arrestin recruitment and the effects of selective D4R ligands on the above-mentioned diseases are discussed." @default.
- W3113827086 created "2021-01-05" @default.
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- W3113827086 date "2021-02-01" @default.
- W3113827086 modified "2023-10-12" @default.
- W3113827086 title "Recent findings leading to the discovery of selective dopamine D4 receptor ligands for the treatment of widespread diseases" @default.
- W3113827086 cites W1556036544 @default.
- W3113827086 cites W1556664326 @default.
- W3113827086 cites W1556727507 @default.
- W3113827086 cites W1578544243 @default.
- W3113827086 cites W1628656799 @default.
- W3113827086 cites W1649187440 @default.
- W3113827086 cites W1786514222 @default.
- W3113827086 cites W1922867421 @default.
- W3113827086 cites W1925492557 @default.
- W3113827086 cites W1966779141 @default.
- W3113827086 cites W1968650106 @default.
- W3113827086 cites W1972261780 @default.
- W3113827086 cites W1972342818 @default.
- W3113827086 cites W1972595109 @default.
- W3113827086 cites W1972857557 @default.
- W3113827086 cites W1973051098 @default.
- W3113827086 cites W1974222274 @default.
- W3113827086 cites W1975977959 @default.
- W3113827086 cites W1977573492 @default.
- W3113827086 cites W1977869470 @default.
- W3113827086 cites W1979179687 @default.
- W3113827086 cites W1980964404 @default.
- W3113827086 cites W1981158847 @default.
- W3113827086 cites W1981610383 @default.
- W3113827086 cites W1985618992 @default.
- W3113827086 cites W1985702170 @default.
- W3113827086 cites W1986488682 @default.
- W3113827086 cites W1988304670 @default.
- W3113827086 cites W1988346800 @default.
- W3113827086 cites W1995523980 @default.
- W3113827086 cites W1998670974 @default.
- W3113827086 cites W1998900400 @default.
- W3113827086 cites W2002325400 @default.
- W3113827086 cites W2004045159 @default.
- W3113827086 cites W2006820554 @default.
- W3113827086 cites W2007980582 @default.
- W3113827086 cites W2009256062 @default.
- W3113827086 cites W2010672805 @default.
- W3113827086 cites W2011033234 @default.
- W3113827086 cites W2012286072 @default.
- W3113827086 cites W2012551802 @default.
- W3113827086 cites W2014746271 @default.
- W3113827086 cites W2015140309 @default.
- W3113827086 cites W2016476236 @default.
- W3113827086 cites W2016943172 @default.
- W3113827086 cites W2017080941 @default.
- W3113827086 cites W2018139815 @default.
- W3113827086 cites W2019189591 @default.
- W3113827086 cites W2023845267 @default.
- W3113827086 cites W2024486693 @default.
- W3113827086 cites W2024598202 @default.
- W3113827086 cites W2026395566 @default.
- W3113827086 cites W2028432389 @default.
- W3113827086 cites W2029091358 @default.
- W3113827086 cites W2031075865 @default.
- W3113827086 cites W2031932072 @default.
- W3113827086 cites W2032332359 @default.
- W3113827086 cites W2034014095 @default.
- W3113827086 cites W2034801399 @default.
- W3113827086 cites W2035317930 @default.
- W3113827086 cites W2036752554 @default.
- W3113827086 cites W2037446646 @default.
- W3113827086 cites W2038538575 @default.
- W3113827086 cites W2043819551 @default.
- W3113827086 cites W2044217732 @default.
- W3113827086 cites W2047473926 @default.
- W3113827086 cites W2051317191 @default.
- W3113827086 cites W2053658521 @default.
- W3113827086 cites W2054560340 @default.
- W3113827086 cites W2056316599 @default.
- W3113827086 cites W2058288237 @default.
- W3113827086 cites W2058977495 @default.
- W3113827086 cites W2059230444 @default.
- W3113827086 cites W2059570358 @default.
- W3113827086 cites W2060156219 @default.
- W3113827086 cites W2060411798 @default.
- W3113827086 cites W2062704469 @default.
- W3113827086 cites W2063840261 @default.
- W3113827086 cites W2065295009 @default.
- W3113827086 cites W2066158398 @default.
- W3113827086 cites W2066430700 @default.
- W3113827086 cites W2066482395 @default.
- W3113827086 cites W2067973462 @default.
- W3113827086 cites W2068057675 @default.