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- W3113851757 endingPage "188500" @default.
- W3113851757 startingPage "188500" @default.
- W3113851757 abstract "Clusterin (CLU) is an evolutionary conserved molecular chaperone present in different human tissues and fluids and established to be a significant cancer regulator. It controls several cancer-associated cellular events, including cancer cell proliferation, stemness, survival, metastasis, epithelial-mesenchymal transition, therapy resistance, and inhibition of programmed cell death to support cancer growth and recurrence. This multifunctional role of CLU makes it an ideal target for cancer control. More importantly, genetic and antisense-mediated (OGX-011) inhibition of CLU enhances the anticancer potential of different FDA-approved chemotherapeutic drugs at the clinical level, improving patient's survival. In this review, we have discussed the detailed mechanism of CLU-mediated modulation of different cancer-associated signaling pathways. We have also provided updated information on the current preclinical and clinical findings that drive trials in various cancer types for potential targeted cancer therapy." @default.
- W3113851757 created "2021-01-05" @default.
- W3113851757 creator A5002697297 @default.
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- W3113851757 creator A5019292973 @default.
- W3113851757 creator A5035317652 @default.
- W3113851757 creator A5043450835 @default.
- W3113851757 date "2021-04-01" @default.
- W3113851757 modified "2023-10-11" @default.
- W3113851757 title "Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy" @default.
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