FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113863876> ?p ?o ?g. }

• W3113863876 endingPage "i927" @default.
• W3113863876 startingPage "i919" @default.
• W3113863876 abstract "Recent technological advances have led to an increase in the production and availability of single-cell data. The ability to integrate a set of multi-technology measurements would allow the identification of biologically or clinically meaningful observations through the unification of the perspectives afforded by each technology. In most cases, however, profiling technologies consume the used cells and thus pairwise correspondences between datasets are lost. Due to the sheer size single-cell datasets can acquire, scalable algorithms that are able to universally match single-cell measurements carried out in one cell to its corresponding sibling in another technology are needed.We propose Single-Cell data Integration via Matching (SCIM), a scalable approach to recover such correspondences in two or more technologies. SCIM assumes that cells share a common (low-dimensional) underlying structure and that the underlying cell distribution is approximately constant across technologies. It constructs a technology-invariant latent space using an autoencoder framework with an adversarial objective. Multi-modal datasets are integrated by pairing cells across technologies using a bipartite matching scheme that operates on the low-dimensional latent representations. We evaluate SCIM on a simulated cellular branching process and show that the cell-to-cell matches derived by SCIM reflect the same pseudotime on the simulated dataset. Moreover, we apply our method to two real-world scenarios, a melanoma tumor sample and a human bone marrow sample, where we pair cells from a scRNA dataset to their sibling cells in a CyTOF dataset achieving 90% and 78% cell-matching accuracy for each one of the samples, respectively.https://github.com/ratschlab/scim.Supplementary data are available at Bioinformatics online." @default.
• W3113863876 created "2021-01-05" @default.
• W3113863876 creator A5005041697 @default.
• W3113863876 creator A5019755983 @default.
• W3113863876 creator A5022555275 @default.
• W3113863876 creator A5035416263 @default.
• W3113863876 creator A5038601102 @default.
• W3113863876 creator A5049334079 @default.
• W3113863876 creator A5069576688 @default.
• W3113863876 creator A5073157306 @default.
• W3113863876 date "2020-12-01" @default.
• W3113863876 modified "2023-10-03" @default.
• W3113863876 title "SCIM: universal single-cell matching with unpaired feature sets" @default.
• W3113863876 cites W1602702667 @default.
• W3113863876 cites W2038254572 @default.
• W3113863876 cites W2053129129 @default.
• W3113863876 cites W2104363966 @default.
• W3113863876 cites W2149573463 @default.
• W3113863876 cites W2150879893 @default.
• W3113863876 cites W2166541787 @default.
• W3113863876 cites W2332292689 @default.
• W3113863876 cites W2611919322 @default.
• W3113863876 cites W2739492614 @default.
• W3113863876 cites W2766959028 @default.
• W3113863876 cites W2794660702 @default.
• W3113863876 cites W2889594596 @default.
• W3113863876 cites W2940982798 @default.
• W3113863876 cites W2948469692 @default.
• W3113863876 cites W2949177718 @default.
• W3113863876 cites W2950030509 @default.
• W3113863876 cites W2951084686 @default.
• W3113863876 cites W2966593302 @default.
• W3113863876 cites W2968352143 @default.
• W3113863876 cites W2978997241 @default.
• W3113863876 cites W2997207862 @default.
• W3113863876 cites W3005957343 @default.
• W3113863876 cites W3010981820 @default.
• W3113863876 cites W3043558371 @default.
• W3113863876 cites W3120224790 @default.
• W3113863876 cites W3122308234 @default.
• W3113863876 doi "https://doi.org/10.1093/bioinformatics/btaa843" @default.
• W3113863876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7773480" @default.
• W3113863876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33381818" @default.
• W3113863876 hasPublicationYear "2020" @default.
• W3113863876 type Work @default.
• W3113863876 sameAs 3113863876 @default.
• W3113863876 citedByCount "36" @default.
• W3113863876 countsByYear W31138638762021 @default.
• W3113863876 countsByYear W31138638762022 @default.
• W3113863876 countsByYear W31138638762023 @default.
• W3113863876 crossrefType "journal-article" @default.
• W3113863876 hasAuthorship W3113863876A5005041697 @default.
• W3113863876 hasAuthorship W3113863876A5019755983 @default.
• W3113863876 hasAuthorship W3113863876A5022555275 @default.
• W3113863876 hasAuthorship W3113863876A5035416263 @default.
• W3113863876 hasAuthorship W3113863876A5038601102 @default.
• W3113863876 hasAuthorship W3113863876A5049334079 @default.
• W3113863876 hasAuthorship W3113863876A5069576688 @default.
• W3113863876 hasAuthorship W3113863876A5073157306 @default.
• W3113863876 hasBestOaLocation W31138638761 @default.
• W3113863876 hasConcept C101738243 @default.
• W3113863876 hasConcept C105795698 @default.
• W3113863876 hasConcept C108583219 @default.
• W3113863876 hasConcept C124101348 @default.
• W3113863876 hasConcept C153180895 @default.
• W3113863876 hasConcept C154945302 @default.
• W3113863876 hasConcept C165064840 @default.
• W3113863876 hasConcept C184898388 @default.
• W3113863876 hasConcept C33923547 @default.
• W3113863876 hasConcept C41008148 @default.
• W3113863876 hasConcept C48044578 @default.
• W3113863876 hasConcept C77088390 @default.
• W3113863876 hasConceptScore W3113863876C101738243 @default.
• W3113863876 hasConceptScore W3113863876C105795698 @default.
• W3113863876 hasConceptScore W3113863876C108583219 @default.
• W3113863876 hasConceptScore W3113863876C124101348 @default.
• W3113863876 hasConceptScore W3113863876C153180895 @default.
• W3113863876 hasConceptScore W3113863876C154945302 @default.
• W3113863876 hasConceptScore W3113863876C165064840 @default.
• W3113863876 hasConceptScore W3113863876C184898388 @default.
• W3113863876 hasConceptScore W3113863876C33923547 @default.
• W3113863876 hasConceptScore W3113863876C41008148 @default.
• W3113863876 hasConceptScore W3113863876C48044578 @default.
• W3113863876 hasConceptScore W3113863876C77088390 @default.
• W3113863876 hasFunder F4320323874 @default.
• W3113863876 hasFunder F4320331705 @default.
• W3113863876 hasIssue "Supplement_2" @default.
• W3113863876 hasLocation W31138638761 @default.
• W3113863876 hasLocation W31138638762 @default.
• W3113863876 hasLocation W31138638763 @default.
• W3113863876 hasLocation W31138638764 @default.
• W3113863876 hasLocation W31138638765 @default.
• W3113863876 hasLocation W31138638766 @default.
• W3113863876 hasLocation W31138638767 @default.
• W3113863876 hasLocation W31138638768 @default.
• W3113863876 hasOpenAccess W3113863876 @default.
• W3113863876 hasPrimaryLocation W31138638761 @default.
• W3113863876 hasRelatedWork W2292254049 @default.

• next