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• W3113884362 abstract "Blood cutoff values for vitamin A deficiency in children aged 3-10 years have not been addressed in the literature.To identify blood retinol concentrations for determining severe vitamin A deficiency in children aged 3-10 years.The MEDLINE, Web of Science, Embase, and Scopus databases were searched.Two reviewers independently extracted article data and assessed quality.The hierarchical summary receiver operating characteristic models were applied for the diagnostic accuracy meta-analysis. This review is registered at PROSPERO (identifier: CRD42020149367).A total of 15 articles met the eligibility criteria, and 9 were included in the diagnostic accuracy meta-analysis. The summary estimates (95%CI) were: Sensitivity, 0.39 (0.20-0.62); specificity, 0.79 (0.65-0.88); positive likelihood ratio, 1.85 (1.33-2.57); and negative likelihood ratio, 0.77 (0.60-0.99). The area under the curve of the overall analysis was 0.68 (95%CI 0.63-0.72).Blood retinol concentrations have low diagnostic accuracy for severe vitamin A deficiency in children aged 3-10 years. Therefore, there is unclear evidence about the preferable cutoff point for determining severe vitamin A deficiency in children in this age group." @default.
• W3113884362 created "2021-01-05" @default.
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• W3113884362 date "2020-12-31" @default.
• W3113884362 modified "2023-10-17" @default.
• W3113884362 title "Which blood cutoff value should be used for vitamin A deficiency in children aged 3–10 years? A systematic review" @default.
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• W3113884362 doi "https://doi.org/10.1093/nutrit/nuaa133" @default.
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