FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114021938> ?p ?o ?g. }

• W3114021938 endingPage "1474" @default.
• W3114021938 startingPage "1474" @default.
• W3114021938 abstract "African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite the recent advances on ASF vaccine development, there are no commercial vaccines yet, and most of the promising vaccine prototypes available today have been specifically designed to fight the genotype II strains currently circulating in Europe, Asia, and Oceania. Previous results from our laboratory have demonstrated the ability of BA71∆CD2, a recombinant LAV lacking CD2v, to confer protection against homologous (BA71) and heterologous genotype I (E75) and genotype II (Georgia2007/01) ASFV strains, both belonging to same clade (clade C). Here, we extend these results using BA71∆CD2 as a tool trying to understand ASFV cross-protection, using phylogenetically distant ASFV strains. We first observed that five out of six (83.3%) of the pigs immunized once with 106 PFU of BA71∆CD2 survived the tick-bite challenge using Ornithodoros sp. soft ticks naturally infected with RSA/11/2017 strain (genotype XIX, clade D). Second, only two out of six (33.3%) survived the challenge with Ken06.Bus (genotype IX, clade A), which is phylogenetically more distant to BA71∆CD2 than the RSA/11/2017 strain. On the other hand, homologous prime-boosting with BA71∆CD2 only improved the survival rate to 50% after Ken06.Bus challenge, all suffering mild ASF-compatible clinical signs, while 100% of the pigs immunized with BA71∆CD2 and boosted with the parental BA71 virulent strain survived the lethal challenge with Ken06.Bus, without almost no clinical signs of the disease. Our results confirm that cross-protection is a multifactorial phenomenon that not only depends on sequence similarity. We believe that understanding this complex phenomenon will be useful for designing future vaccines for ASF-endemic areas." @default.
• W3114021938 created "2021-01-05" @default.
• W3114021938 creator A5012406054 @default.
• W3114021938 creator A5019560166 @default.
• W3114021938 creator A5019822761 @default.
• W3114021938 creator A5029661828 @default.
• W3114021938 creator A5032683672 @default.
• W3114021938 creator A5035714798 @default.
• W3114021938 creator A5041067381 @default.
• W3114021938 creator A5052829420 @default.
• W3114021938 creator A5057417720 @default.
• W3114021938 creator A5064409393 @default.
• W3114021938 creator A5066369146 @default.
• W3114021938 creator A5077009270 @default.
• W3114021938 date "2020-12-21" @default.
• W3114021938 modified "2023-10-18" @default.
• W3114021938 title "Live Attenuated African Swine Fever Viruses as Ideal Tools to Dissect the Mechanisms Involved in Cross-Protection" @default.
• W3114021938 cites W1535598811 @default.
• W3114021938 cites W1980827162 @default.
• W3114021938 cites W1998839071 @default.
• W3114021938 cites W2000932522 @default.
• W3114021938 cites W2016158866 @default.
• W3114021938 cites W2017019498 @default.
• W3114021938 cites W2030054290 @default.
• W3114021938 cites W2060614612 @default.
• W3114021938 cites W2063380914 @default.
• W3114021938 cites W2075205036 @default.
• W3114021938 cites W2087601007 @default.
• W3114021938 cites W2091184098 @default.
• W3114021938 cites W2132632499 @default.
• W3114021938 cites W2136337426 @default.
• W3114021938 cites W2146773981 @default.
• W3114021938 cites W2148884752 @default.
• W3114021938 cites W2156629385 @default.
• W3114021938 cites W2167008898 @default.
• W3114021938 cites W2167195856 @default.
• W3114021938 cites W2186713325 @default.
• W3114021938 cites W2345254528 @default.
• W3114021938 cites W2595444194 @default.
• W3114021938 cites W2734609203 @default.
• W3114021938 cites W2750227535 @default.
• W3114021938 cites W2762055825 @default.
• W3114021938 cites W2773182043 @default.
• W3114021938 cites W2781785017 @default.
• W3114021938 cites W2790365688 @default.
• W3114021938 cites W2941821736 @default.
• W3114021938 cites W2949793465 @default.
• W3114021938 cites W2999006774 @default.
• W3114021938 cites W3009223043 @default.
• W3114021938 cites W3011991772 @default.
• W3114021938 cites W3014634328 @default.
• W3114021938 cites W3038620702 @default.
• W3114021938 cites W328539804 @default.
• W3114021938 doi "https://doi.org/10.3390/v12121474" @default.
• W3114021938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7767464" @default.
• W3114021938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33371460" @default.
• W3114021938 hasPublicationYear "2020" @default.
• W3114021938 type Work @default.
• W3114021938 sameAs 3114021938 @default.
• W3114021938 citedByCount "24" @default.
• W3114021938 countsByYear W31140219382021 @default.
• W3114021938 countsByYear W31140219382022 @default.
• W3114021938 countsByYear W31140219382023 @default.
• W3114021938 crossrefType "journal-article" @default.
• W3114021938 hasAuthorship W3114021938A5012406054 @default.
• W3114021938 hasAuthorship W3114021938A5019560166 @default.
• W3114021938 hasAuthorship W3114021938A5019822761 @default.
• W3114021938 hasAuthorship W3114021938A5029661828 @default.
• W3114021938 hasAuthorship W3114021938A5032683672 @default.
• W3114021938 hasAuthorship W3114021938A5035714798 @default.
• W3114021938 hasAuthorship W3114021938A5041067381 @default.
• W3114021938 hasAuthorship W3114021938A5052829420 @default.
• W3114021938 hasAuthorship W3114021938A5057417720 @default.
• W3114021938 hasAuthorship W3114021938A5064409393 @default.
• W3114021938 hasAuthorship W3114021938A5066369146 @default.
• W3114021938 hasAuthorship W3114021938A5077009270 @default.
• W3114021938 hasBestOaLocation W31140219381 @default.
• W3114021938 hasConcept C104317684 @default.
• W3114021938 hasConcept C105702510 @default.
• W3114021938 hasConcept C135763542 @default.
• W3114021938 hasConcept C159047783 @default.
• W3114021938 hasConcept C193252679 @default.
• W3114021938 hasConcept C2522874641 @default.
• W3114021938 hasConcept C2776665880 @default.
• W3114021938 hasConcept C2778022156 @default.
• W3114021938 hasConcept C2778359420 @default.
• W3114021938 hasConcept C2779620486 @default.
• W3114021938 hasConcept C2780115692 @default.
• W3114021938 hasConcept C44465124 @default.
• W3114021938 hasConcept C54355233 @default.
• W3114021938 hasConcept C86803240 @default.
• W3114021938 hasConceptScore W3114021938C104317684 @default.
• W3114021938 hasConceptScore W3114021938C105702510 @default.
• W3114021938 hasConceptScore W3114021938C135763542 @default.
• W3114021938 hasConceptScore W3114021938C159047783 @default.
• W3114021938 hasConceptScore W3114021938C193252679 @default.
• W3114021938 hasConceptScore W3114021938C2522874641 @default.
• W3114021938 hasConceptScore W3114021938C2776665880 @default.

• next