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• W3114042937 abstract "Context: The increase in the prevalence of neurodevelopmental disorders warrants identification of the possible underlying modifiable risk factors. Pregnant women are constantly exposed to several phenols and phthalates that are endocrine disrupting chemicals and have been linked to various adverse neurodevelopmental outcomes in toxicological studies. One of the suggested mechanisms of neurotoxicity of these compounds is by disruption of the thyroid hormone pathway.Aims: 1) To document if the use of personal care products (PCP) could influence phenols biomarkers concentrations during pregnancy; 2) to assess associations between prenatal exposure to phenols and phthalates and child neurodevelopment; and 3) to assess associations between prenatal exposure to phenols and phthalates on the thyroid hormone levels of pregnant women and their newborns.Methods: We relied on three complementary cohorts; the SEPAGES-feasibility study with multiple urine samples and detailed, time-resolved information on PCP use, the EDEN cohort with maternal urinary concentrations of phenols, phthalates and information on child neurodevelopment and the SEPAGES cohort with information on gestational exposure to phenols and phthalates (assessed in 2 pools of 21 urine sample per participant) and levels of thyroid hormones levels during pregnancy and at birth.Results: The total number of PCP applications (without distinction) was positively associated with the parabens’ and bisphenol S urinary concentrations during pregnancy but not with other phenols assessed (benzophenone-3, triclosan and bisphenol A).No phenol or phthalate metabolite pregnancy concentration was negatively associated with IQ of boys at 5 years. Some associations with child behavior were observed at 3 and 5 years: Bisphenol A was positively associated with the relationship problems subscale at 3 years and the hyperactivity–inattention subscale scores at 5 years. Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problems, and emotional symptom scores at 3 years. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 years. After dichotomizing behavioral scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 years.Regarding the associations with maternal hormones, bisphenol A was negatively associated with the Ln (TSH) z-score; MBzP, a metabolite of benzylbutyl phthalate (BBP), was positively associated with the TT4 z-score and triclosan was negatively associated with the TT3/TT4 ratio z-score. When biomarker concentrations were categorized in tertiles, we observed non-monotonic associations between TSH and triclosan (U-shape) and MnBP, a metabolite of di-n-butyl phthalate (DBP) (inverse U-shape). In newborns, only sex-specific effects were observed: bisphenol A was positively associated with the TT4 z-score in male newborns while triclosan was negatively associated with the TT4 z-score in females.Conclusion: Findings in this study concur with previous literature that PCPs use may contribute to exposure to parabens. Our study was the first to report associations between PCP use and bisphenol S, a substitute of bisphenol A. In line with previous studies, bisphenol A and various phthalates, including DBP and BBP exposure during pregnancy, were associated adverse behavioral symptoms among boys. Our study was the first to report adverse neurobehavioral effects in relation to triclosan exposure. The four compounds associated with adverse behavioral effects in EDEN were also associated with one or more thyroid hormone levels of mothers or newborns in the SEPAGES cohort, suggesting possible disruption of thyroid hormones homeostasis." @default.
• W3114042937 created "2021-01-05" @default.
• W3114042937 creator A5078945905 @default.
• W3114042937 date "2020-02-14" @default.
• W3114042937 modified "2023-09-23" @default.
• W3114042937 title "Prenatal exposure to phenols and phthalates, child neurodevelopment and the role of the thyroid hormones" @default.
• W3114042937 hasPublicationYear "2020" @default.
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