Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114070928> ?p ?o ?g. }
- W3114070928 endingPage "314" @default.
- W3114070928 startingPage "303" @default.
- W3114070928 abstract "The interactions between cells and their extracellular matrix (ECM) are critically important for homeostatic control of cell growth, proliferation, differentiation and apoptosis. Transmembrane integrin molecules facilitate the communication between ECM and the cell. Since the characterization of integrins in the late 1980s, there has been great advancement in understanding the function of integrins at different subcellular levels. However, the versatility in molecular pathways integrins are involved in, the high diversity in their interaction partners both outside and inside the cell as well as on the cell membrane and the short lifetime of events happening at the cell–ECM interface make it difficult to elucidate all the details regarding integrin function experimentally. To overcome the experimental challenges and advance the understanding of integrin biology, computational modeling tools have been used extensively. In this review, we summarize the computational models of integrin signaling while we explain the function of integrins at three main subcellular levels (outside the cell, cell membrane, cytosol). We also discuss how these computational modeling efforts can be helpful in other disciplines such as biomaterial design. As such, this review is a didactic modeling summary for biomaterial researchers interested in complementing their experimental work with computational tools or for seasoned computational scientists that would like to advance current in silico integrin models." @default.
- W3114070928 created "2021-01-05" @default.
- W3114070928 creator A5029574413 @default.
- W3114070928 creator A5030920366 @default.
- W3114070928 creator A5032492321 @default.
- W3114070928 creator A5034277829 @default.
- W3114070928 creator A5077350753 @default.
- W3114070928 date "2021-01-01" @default.
- W3114070928 modified "2023-10-01" @default.
- W3114070928 title "Towards understanding the messengers of extracellular space: Computational models of outside-in integrin reaction networks" @default.
- W3114070928 cites W1576773659 @default.
- W3114070928 cites W1811064827 @default.
- W3114070928 cites W1862989971 @default.
- W3114070928 cites W1964512641 @default.
- W3114070928 cites W1965259349 @default.
- W3114070928 cites W1966039706 @default.
- W3114070928 cites W1968316337 @default.
- W3114070928 cites W1971593855 @default.
- W3114070928 cites W1972205817 @default.
- W3114070928 cites W1973757009 @default.
- W3114070928 cites W1988176449 @default.
- W3114070928 cites W1988425397 @default.
- W3114070928 cites W1989046246 @default.
- W3114070928 cites W1991822827 @default.
- W3114070928 cites W1992478375 @default.
- W3114070928 cites W1998882797 @default.
- W3114070928 cites W2001339111 @default.
- W3114070928 cites W2008454162 @default.
- W3114070928 cites W2013221517 @default.
- W3114070928 cites W2013381560 @default.
- W3114070928 cites W2022746045 @default.
- W3114070928 cites W2025642009 @default.
- W3114070928 cites W2026043488 @default.
- W3114070928 cites W2026185507 @default.
- W3114070928 cites W2031504285 @default.
- W3114070928 cites W2040916923 @default.
- W3114070928 cites W2041772318 @default.
- W3114070928 cites W2044859335 @default.
- W3114070928 cites W2055787241 @default.
- W3114070928 cites W2057466720 @default.
- W3114070928 cites W2069390069 @default.
- W3114070928 cites W2069752642 @default.
- W3114070928 cites W2078734278 @default.
- W3114070928 cites W2085733738 @default.
- W3114070928 cites W2086244192 @default.
- W3114070928 cites W2091119718 @default.
- W3114070928 cites W2091139254 @default.
- W3114070928 cites W2095914211 @default.
- W3114070928 cites W2099487193 @default.
- W3114070928 cites W2100345558 @default.
- W3114070928 cites W2101244168 @default.
- W3114070928 cites W2101768141 @default.
- W3114070928 cites W2102661335 @default.
- W3114070928 cites W2103883318 @default.
- W3114070928 cites W2105183595 @default.
- W3114070928 cites W2111166332 @default.
- W3114070928 cites W2112195516 @default.
- W3114070928 cites W2114989145 @default.
- W3114070928 cites W2115044953 @default.
- W3114070928 cites W2118585187 @default.
- W3114070928 cites W2123759534 @default.
- W3114070928 cites W2125282225 @default.
- W3114070928 cites W2127170661 @default.
- W3114070928 cites W2130123417 @default.
- W3114070928 cites W2136949471 @default.
- W3114070928 cites W2160615561 @default.
- W3114070928 cites W2161301127 @default.
- W3114070928 cites W2162591509 @default.
- W3114070928 cites W2162812796 @default.
- W3114070928 cites W2164244652 @default.
- W3114070928 cites W2169830285 @default.
- W3114070928 cites W2341109105 @default.
- W3114070928 cites W2549070824 @default.
- W3114070928 cites W2552754421 @default.
- W3114070928 cites W2556725207 @default.
- W3114070928 cites W2575770495 @default.
- W3114070928 cites W2582873639 @default.
- W3114070928 cites W2606611964 @default.
- W3114070928 cites W2712373469 @default.
- W3114070928 cites W2731593192 @default.
- W3114070928 cites W2741871742 @default.
- W3114070928 cites W2756785816 @default.
- W3114070928 cites W2771412072 @default.
- W3114070928 cites W2775236679 @default.
- W3114070928 cites W2788813648 @default.
- W3114070928 cites W2794013167 @default.
- W3114070928 cites W2883161420 @default.
- W3114070928 cites W2884300959 @default.
- W3114070928 cites W2906323450 @default.
- W3114070928 cites W2913201050 @default.
- W3114070928 cites W2915023799 @default.
- W3114070928 cites W2915478900 @default.
- W3114070928 cites W2940151469 @default.
- W3114070928 cites W2955596421 @default.
- W3114070928 cites W2971731462 @default.
- W3114070928 cites W2973047143 @default.
- W3114070928 cites W3006062529 @default.
- W3114070928 cites W3006793445 @default.