Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114106786> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3114106786 endingPage "65" @default.
- W3114106786 startingPage "61" @default.
- W3114106786 abstract "Introduction: Satureja khozestanica grows mainly in the southwest part of Iran as a native plant. This edible herb contains various compounds including the S. Khuzestanica essential oil (SKEO) and monoterpene known as Carvacrol. Previous studies have shown the anti-inflammatory effects of S. Khuzestanica without mentioning the exact mechanism of its function. Given that prostaglandin synthesis, which is one of the main mediators of inflammation, is regulated by the cyclooxygenase-2 (COX2) gene, the present study investigated the effects of SKEO and Carvacrol on the expression of the COX2 gene in the stimulated-J774A.1 macrophage cell line. Methods: To this end, fresh aerial parts of the plant were processed to prepare SKEO. Then, different doses of SKEO and Carvacrol (i.e., 0.004%, 0.008%, and 0.016% v/v) were used to treat with the lipopolysaccharides (LPS)-stimulated cell line for eight hours. After RNA extraction, the real-time polymerase chain reaction technique was applied for gene expression analysis. Results: In the LPS-stimulated J774A.1 macrophage cell line, COX2 gene expression reduced significantly in a dose-dependent manner (0.004%, 0.008%, and 0.016%, P = 0.024, P = 0.021, and P = 0.013 v/v of SKEO, respectively) by SKEO, and the effect of Carvacrol was less powerful (0.008% and 0.016%, P = 0.027 and P = 0.038 v/v, respectively) compared to SKEO. Finally, the comparison between SKEO and Carvacrol showed higher significant inhibitory effects of SKEO on COX2 gene expression in comparison with Carvacrol in 0.004% v/v concentration (P = 0.037). Conclusion: In general, SKEO significantly reduced COX2 gene expression, thus it can be suggested that its anti-inflammatory effect may result from the inhibition of the synthesis of this pro-inflammatory gene." @default.
- W3114106786 created "2021-01-05" @default.
- W3114106786 creator A5005733348 @default.
- W3114106786 creator A5052019040 @default.
- W3114106786 creator A5052355979 @default.
- W3114106786 creator A5053931192 @default.
- W3114106786 creator A5089136452 @default.
- W3114106786 date "2020-06-30" @default.
- W3114106786 modified "2023-10-16" @default.
- W3114106786 title "In vitro Anti-inflammatory Effects of Satureja Kkhuzestanica Essential Oil Compared to Carvacrol" @default.
- W3114106786 cites W1594425991 @default.
- W3114106786 cites W1973922450 @default.
- W3114106786 cites W1994153742 @default.
- W3114106786 cites W1997208118 @default.
- W3114106786 cites W2004555438 @default.
- W3114106786 cites W2006341462 @default.
- W3114106786 cites W2012344270 @default.
- W3114106786 cites W2027698993 @default.
- W3114106786 cites W2078588075 @default.
- W3114106786 cites W2085852125 @default.
- W3114106786 cites W2114375386 @default.
- W3114106786 cites W2120512016 @default.
- W3114106786 cites W2132219482 @default.
- W3114106786 cites W2138002999 @default.
- W3114106786 cites W2144505504 @default.
- W3114106786 cites W2155380597 @default.
- W3114106786 cites W2158960911 @default.
- W3114106786 cites W2166945540 @default.
- W3114106786 cites W2167362639 @default.
- W3114106786 doi "https://doi.org/10.34172/ijbsm.2020.12" @default.
- W3114106786 hasPublicationYear "2020" @default.
- W3114106786 type Work @default.
- W3114106786 sameAs 3114106786 @default.
- W3114106786 citedByCount "1" @default.
- W3114106786 countsByYear W31141067862023 @default.
- W3114106786 crossrefType "journal-article" @default.
- W3114106786 hasAuthorship W3114106786A5005733348 @default.
- W3114106786 hasAuthorship W3114106786A5052019040 @default.
- W3114106786 hasAuthorship W3114106786A5052355979 @default.
- W3114106786 hasAuthorship W3114106786A5053931192 @default.
- W3114106786 hasAuthorship W3114106786A5089136452 @default.
- W3114106786 hasBestOaLocation W31141067861 @default.
- W3114106786 hasConcept C104317684 @default.
- W3114106786 hasConcept C150194340 @default.
- W3114106786 hasConcept C170493617 @default.
- W3114106786 hasConcept C185592680 @default.
- W3114106786 hasConcept C202751555 @default.
- W3114106786 hasConcept C2777278459 @default.
- W3114106786 hasConcept C2777383412 @default.
- W3114106786 hasConcept C2777671706 @default.
- W3114106786 hasConcept C2780676017 @default.
- W3114106786 hasConcept C31903555 @default.
- W3114106786 hasConcept C55493867 @default.
- W3114106786 hasConcept C556039675 @default.
- W3114106786 hasConcept C71924100 @default.
- W3114106786 hasConcept C86803240 @default.
- W3114106786 hasConcept C98274493 @default.
- W3114106786 hasConceptScore W3114106786C104317684 @default.
- W3114106786 hasConceptScore W3114106786C150194340 @default.
- W3114106786 hasConceptScore W3114106786C170493617 @default.
- W3114106786 hasConceptScore W3114106786C185592680 @default.
- W3114106786 hasConceptScore W3114106786C202751555 @default.
- W3114106786 hasConceptScore W3114106786C2777278459 @default.
- W3114106786 hasConceptScore W3114106786C2777383412 @default.
- W3114106786 hasConceptScore W3114106786C2777671706 @default.
- W3114106786 hasConceptScore W3114106786C2780676017 @default.
- W3114106786 hasConceptScore W3114106786C31903555 @default.
- W3114106786 hasConceptScore W3114106786C55493867 @default.
- W3114106786 hasConceptScore W3114106786C556039675 @default.
- W3114106786 hasConceptScore W3114106786C71924100 @default.
- W3114106786 hasConceptScore W3114106786C86803240 @default.
- W3114106786 hasConceptScore W3114106786C98274493 @default.
- W3114106786 hasIssue "2" @default.
- W3114106786 hasLocation W31141067861 @default.
- W3114106786 hasLocation W31141067862 @default.
- W3114106786 hasOpenAccess W3114106786 @default.
- W3114106786 hasPrimaryLocation W31141067861 @default.
- W3114106786 hasRelatedWork W1970178610 @default.
- W3114106786 hasRelatedWork W1972914098 @default.
- W3114106786 hasRelatedWork W1979158560 @default.
- W3114106786 hasRelatedWork W2007209086 @default.
- W3114106786 hasRelatedWork W2064470344 @default.
- W3114106786 hasRelatedWork W2226115371 @default.
- W3114106786 hasRelatedWork W2958783547 @default.
- W3114106786 hasRelatedWork W3047697029 @default.
- W3114106786 hasRelatedWork W3114106786 @default.
- W3114106786 hasRelatedWork W4225271993 @default.
- W3114106786 hasVolume "5" @default.
- W3114106786 isParatext "false" @default.
- W3114106786 isRetracted "false" @default.
- W3114106786 magId "3114106786" @default.
- W3114106786 workType "article" @default.