Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114127171> ?p ?o ?g. }
- W3114127171 endingPage "114083" @default.
- W3114127171 startingPage "114083" @default.
- W3114127171 abstract "In rapidly dividing cells, including many cancer cells, l-glutamine is a major energy source. Utilization of glutamine is usually depicted as: l-glutamine → l-glutamate (catalyzed by glutaminase isozymes; GLS1 and GLS2), followed by l-glutamate → α-ketoglutarate [catalyzed by glutamate-linked aminotransferases or by glutamate dehydrogenase (GDH)]. α-Ketoglutarate is a major anaplerotic component of the tricarboxylic acid (TCA) cycle. However, the glutaminase II pathway also converts l-glutamine to α-ketoglutarate. This pathway consists of a glutamine transaminase coupled to ω-amidase [Net reaction: l-Glutamine + α-keto acid + H2O → α-ketoglutarate + l-amino acid + NH4+]. This review focuses on the biological importance of the glutaminase II pathway, especially in relation to metabolism of cancer cells. Our studies suggest a component enzyme of the glutaminase II pathway, ω-amidase, is utilized by tumor cells to provide anaplerotic carbon. Inhibitors of GLS1 are currently in clinical trials as anti-cancer agents. However, this treatment will not prevent the glutaminase II pathway from providing anaplerotic carbon derived from glutamine. Specific inhibitors of ω-amidase, perhaps in combination with a GLS1 inhibitor, may provide greater therapeutic efficacy." @default.
- W3114127171 created "2021-01-05" @default.
- W3114127171 creator A5008059478 @default.
- W3114127171 creator A5048715121 @default.
- W3114127171 creator A5051052158 @default.
- W3114127171 creator A5062259152 @default.
- W3114127171 creator A5070147281 @default.
- W3114127171 date "2022-05-01" @default.
- W3114127171 modified "2023-10-17" @default.
- W3114127171 title "The metabolic importance of the glutaminase II pathway in normal and cancerous cells" @default.
- W3114127171 cites W143465126 @default.
- W3114127171 cites W1493415606 @default.
- W3114127171 cites W1517976100 @default.
- W3114127171 cites W1518778120 @default.
- W3114127171 cites W1521429354 @default.
- W3114127171 cites W1529940313 @default.
- W3114127171 cites W1548928425 @default.
- W3114127171 cites W155569352 @default.
- W3114127171 cites W1569351449 @default.
- W3114127171 cites W1575126937 @default.
- W3114127171 cites W1581414347 @default.
- W3114127171 cites W1596025578 @default.
- W3114127171 cites W1651420115 @default.
- W3114127171 cites W1692886302 @default.
- W3114127171 cites W182121841 @default.
- W3114127171 cites W1846277680 @default.
- W3114127171 cites W1887033179 @default.
- W3114127171 cites W1928711870 @default.
- W3114127171 cites W1942365328 @default.
- W3114127171 cites W1954473336 @default.
- W3114127171 cites W1963712846 @default.
- W3114127171 cites W1967418267 @default.
- W3114127171 cites W1967792461 @default.
- W3114127171 cites W1968979116 @default.
- W3114127171 cites W1969256905 @default.
- W3114127171 cites W1974167994 @default.
- W3114127171 cites W1979371794 @default.
- W3114127171 cites W1982658241 @default.
- W3114127171 cites W1984633970 @default.
- W3114127171 cites W1989467526 @default.
- W3114127171 cites W1991783327 @default.
- W3114127171 cites W1991895421 @default.
- W3114127171 cites W1997466270 @default.
- W3114127171 cites W1998648476 @default.
- W3114127171 cites W1998839744 @default.
- W3114127171 cites W2001749903 @default.
- W3114127171 cites W2004422115 @default.
- W3114127171 cites W2007307339 @default.
- W3114127171 cites W2009950824 @default.
- W3114127171 cites W2013190667 @default.
- W3114127171 cites W2020991192 @default.
- W3114127171 cites W202254273 @default.
- W3114127171 cites W2026788277 @default.
- W3114127171 cites W2027786827 @default.
- W3114127171 cites W2030474642 @default.
- W3114127171 cites W2031654513 @default.
- W3114127171 cites W2033228549 @default.
- W3114127171 cites W2034261447 @default.
- W3114127171 cites W2035739191 @default.
- W3114127171 cites W2036083342 @default.
- W3114127171 cites W2043866553 @default.
- W3114127171 cites W2045813860 @default.
- W3114127171 cites W2046798012 @default.
- W3114127171 cites W2048221026 @default.
- W3114127171 cites W2049775195 @default.
- W3114127171 cites W2054119562 @default.
- W3114127171 cites W2060934232 @default.
- W3114127171 cites W2066628203 @default.
- W3114127171 cites W2067776505 @default.
- W3114127171 cites W2068105612 @default.
- W3114127171 cites W2068216768 @default.
- W3114127171 cites W2069169216 @default.
- W3114127171 cites W2069290232 @default.
- W3114127171 cites W2072495646 @default.
- W3114127171 cites W2073094065 @default.
- W3114127171 cites W2077301757 @default.
- W3114127171 cites W2080249751 @default.
- W3114127171 cites W2080349528 @default.
- W3114127171 cites W2086920509 @default.
- W3114127171 cites W2088708859 @default.
- W3114127171 cites W2107261824 @default.
- W3114127171 cites W2110282379 @default.
- W3114127171 cites W2113240092 @default.
- W3114127171 cites W2113745863 @default.
- W3114127171 cites W2116085563 @default.
- W3114127171 cites W2121262075 @default.
- W3114127171 cites W2128106102 @default.
- W3114127171 cites W2133772088 @default.
- W3114127171 cites W2138818608 @default.
- W3114127171 cites W2142084327 @default.
- W3114127171 cites W2147039156 @default.
- W3114127171 cites W2156264079 @default.
- W3114127171 cites W2161982488 @default.
- W3114127171 cites W2163628857 @default.
- W3114127171 cites W2164735661 @default.
- W3114127171 cites W2169740379 @default.
- W3114127171 cites W2169903226 @default.
- W3114127171 cites W2174449124 @default.