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- W3114143105 abstract "Abstract The position of the axon initial segment (AIS) is thought to play a critical role in neuronal excitability. In particular, empirical studies have found correlations between a distal shift in AIS position and a reduction of excitability. Yet, theoretical work has suggested that the neuron should become more excitable as the distance between soma and AIS is increased, because of increased electrical isolation. Specifically, resistive coupling theory predicts that the action potential (AP) threshold decreases with the logarithm of the axial resistance (R a ) between the middle of the AIS and the soma. However, no direct experimental evidence has been provided so far to support this theoretical prediction. We therefore examined how changes in R a at the axon hillock impact the voltage threshold (V th ) of the somatic AP in L5 pyramidal neurons. Increasing R a by mechanically pinching the axon between the soma and the AIS was found to lower the spike threshold by ~6 mV. Conversely, decreasing R a by replacing a weakly mobile ion (gluconate) by a highly mobile ion (chloride) elevated the spike threshold. All R a -dependent changes in spike threshold could be reproduced in a Hodgkin-Huxley compartmental model. We conclude that in L5 pyramidal neurons, excitability increases with axial resistance, and therefore with a distal shift of the AIS." @default.
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- W3114143105 date "2020-12-28" @default.
- W3114143105 modified "2023-10-18" @default.
- W3114143105 title "Neural excitability increases with axonal resistance between soma and axon initial segment" @default.
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- W3114143105 doi "https://doi.org/10.1101/2020.12.28.424531" @default.
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