FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114263855> ?p ?o ?g. }

• W3114263855 endingPage "200" @default.
• W3114263855 startingPage "189" @default.
• W3114263855 abstract "Abstract miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles in human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how miR-195-5p is involved in malignant behaviors of lung adenocarcinoma (LUAD) cells. miR-195-5p expression was examined in the tumor tissues of patients with LUAD and human LUAD cell lines including A549 and PC-9. Thioredoxin reductase 2 (TrxR2) was predicted to be an mRNA target of miR-195-5p using online tools and validated by the Dual-Luciferase Reporter Assay. Lentivirus infection was used for gene overexpression, while gene knockdown was achieved by RNA interference. Cell proliferation was determined by Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine methods, and cell migration and invasion were assayed with transwell experiments. Cell apoptosis was determined by annexin V staining-based flow cytometry. The antitumor effects of miR-195-5p were also evaluated in nude mice xenografted with A549 cells. We found that miR-195-5p was lowly expressed in human LUAD cells, and its overexpression markedly suppressed cell proliferation, migration, and invasion and increased the apoptosis of LUAD cells in vitro. TrxR2 knockdown phenocopied the tumor-suppressive effects of miR-195-5p overexpression, while simultaneous TrxR2 overexpression remarkably reversed the effects of miR-195-5p overexpression on malignant behaviors of A549 and PC-9 cells. Additionally, miR-195-5p overexpression inhibited the growth of xenografted A549 tumor in nude mice. Our work verified that miR-195-5p exerts tumor-suppressive functions in LUAD cells through targeting TrxR2 and suggested that the miR-195-5p/TrxR2 axis is a potential biomarker for LUAD therapy." @default.
• W3114263855 created "2021-01-05" @default.
• W3114263855 creator A5023513530 @default.
• W3114263855 creator A5028672973 @default.
• W3114263855 creator A5085021148 @default.
• W3114263855 creator A5085595821 @default.
• W3114263855 creator A5088081268 @default.
• W3114263855 date "2020-12-01" @default.
• W3114263855 modified "2023-09-24" @default.
• W3114263855 title "miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2" @default.
• W3114263855 cites W144423133 @default.
• W3114263855 cites W1668103443 @default.
• W3114263855 cites W1965390171 @default.
• W3114263855 cites W1965402320 @default.
• W3114263855 cites W1980086349 @default.
• W3114263855 cites W2032541751 @default.
• W3114263855 cites W2042907812 @default.
• W3114263855 cites W2044967196 @default.
• W3114263855 cites W2049006708 @default.
• W3114263855 cites W2061018077 @default.
• W3114263855 cites W2070353264 @default.
• W3114263855 cites W2073688130 @default.
• W3114263855 cites W2080671488 @default.
• W3114263855 cites W2105493915 @default.
• W3114263855 cites W2107277218 @default.
• W3114263855 cites W2125729223 @default.
• W3114263855 cites W2131399736 @default.
• W3114263855 cites W2155431361 @default.
• W3114263855 cites W2165200432 @default.
• W3114263855 cites W2323065722 @default.
• W3114263855 cites W2347048968 @default.
• W3114263855 cites W2515969222 @default.
• W3114263855 cites W2561204111 @default.
• W3114263855 cites W2562199276 @default.
• W3114263855 cites W2605783251 @default.
• W3114263855 cites W2709224048 @default.
• W3114263855 cites W2793353518 @default.
• W3114263855 cites W2799629815 @default.
• W3114263855 cites W2799795532 @default.
• W3114263855 cites W2887154584 @default.
• W3114263855 cites W2889646458 @default.
• W3114263855 cites W2897825874 @default.
• W3114263855 cites W2898458708 @default.
• W3114263855 cites W2900827073 @default.
• W3114263855 cites W2909146001 @default.
• W3114263855 cites W2911188335 @default.
• W3114263855 cites W2911682418 @default.
• W3114263855 cites W2928893181 @default.
• W3114263855 cites W2929491112 @default.
• W3114263855 cites W2947909968 @default.
• W3114263855 cites W2965919291 @default.
• W3114263855 cites W2973854436 @default.
• W3114263855 cites W2996643695 @default.
• W3114263855 cites W3025716972 @default.
• W3114263855 cites W4252780045 @default.
• W3114263855 doi "https://doi.org/10.1093/abbs/gmaa159" @default.
• W3114263855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33332541" @default.
• W3114263855 hasPublicationYear "2020" @default.
• W3114263855 type Work @default.
• W3114263855 sameAs 3114263855 @default.
• W3114263855 citedByCount "8" @default.
• W3114263855 countsByYear W31142638552021 @default.
• W3114263855 countsByYear W31142638552022 @default.
• W3114263855 countsByYear W31142638552023 @default.
• W3114263855 crossrefType "journal-article" @default.
• W3114263855 hasAuthorship W3114263855A5023513530 @default.
• W3114263855 hasAuthorship W3114263855A5028672973 @default.
• W3114263855 hasAuthorship W3114263855A5085021148 @default.
• W3114263855 hasAuthorship W3114263855A5085595821 @default.
• W3114263855 hasAuthorship W3114263855A5088081268 @default.
• W3114263855 hasConcept C126322002 @default.
• W3114263855 hasConcept C185592680 @default.
• W3114263855 hasConcept C2776256026 @default.
• W3114263855 hasConcept C2777714996 @default.
• W3114263855 hasConcept C2779744229 @default.
• W3114263855 hasConcept C502942594 @default.
• W3114263855 hasConcept C71924100 @default.
• W3114263855 hasConcept C86803240 @default.
• W3114263855 hasConcept C95444343 @default.
• W3114263855 hasConceptScore W3114263855C126322002 @default.
• W3114263855 hasConceptScore W3114263855C185592680 @default.
• W3114263855 hasConceptScore W3114263855C2776256026 @default.
• W3114263855 hasConceptScore W3114263855C2777714996 @default.
• W3114263855 hasConceptScore W3114263855C2779744229 @default.
• W3114263855 hasConceptScore W3114263855C502942594 @default.
• W3114263855 hasConceptScore W3114263855C71924100 @default.
• W3114263855 hasConceptScore W3114263855C86803240 @default.
• W3114263855 hasConceptScore W3114263855C95444343 @default.
• W3114263855 hasFunder F4320321001 @default.
• W3114263855 hasIssue "2" @default.
• W3114263855 hasLocation W31142638551 @default.
• W3114263855 hasOpenAccess W3114263855 @default.
• W3114263855 hasPrimaryLocation W31142638551 @default.
• W3114263855 hasRelatedWork W1967103478 @default.
• W3114263855 hasRelatedWork W2062096219 @default.
• W3114263855 hasRelatedWork W2372561159 @default.
• W3114263855 hasRelatedWork W2375344515 @default.
• W3114263855 hasRelatedWork W2380382254 @default.

• next