FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3114339968> ?p ?o ?g. }

• W3114339968 endingPage "110457" @default.
• W3114339968 startingPage "110457" @default.
• W3114339968 abstract "A ubiquitous finding on MRI in older individuals, age-related cerebral white matter hyperintensities (WMHs) are associated with cognitive decline, dementia, disability, and death. Currently, these findings are thought to represent small infarcts secondary to lipohyalinotic arteriosclerosis. Commonly though, the anatomic distribution of WMHs is often non-arterial, and parallel the deep venous system. Furthermore, there is discrepant evidence for the role of conventional vascular risk factors such as hypertension, carotid atherosclerosis and diabetes for the development and progression of these. Interventions targeting conventional vascular risk factors lack consistency in preventing the progression of WMHs. There is evidence for age-related hemodynamic cervical venous dysfunction resulting in reduced internal jugular vein venous compliance, venous dilatation, and venous reflux. Similarly, venous collagenosis increases with age. Increased blood–brain barrier (BBB) permeability is also noted with aging. Both hemodynamic venous dysfunction, venous sclerosis, and increased BBB permeability are associated with WMHs. We propose that age-related WMHs are a sequalae of venous dysfunction. Venous dysfunction results initially in increased transmission of venous pressures to the brain. Subsequent BBB disruption leads to increased permeability with progression to end-stage findings of age-related WMHs." @default.
• W3114339968 created "2021-01-05" @default.
• W3114339968 creator A5086988650 @default.
• W3114339968 creator A5091158883 @default.
• W3114339968 date "2021-01-01" @default.
• W3114339968 modified "2023-09-25" @default.
• W3114339968 title "Venous dysfunction plays a critical role in “normal” white matter disease of aging" @default.
• W3114339968 cites W1493258939 @default.
• W3114339968 cites W1910162587 @default.
• W3114339968 cites W191849520 @default.
• W3114339968 cites W1983943145 @default.
• W3114339968 cites W1996470432 @default.
• W3114339968 cites W2009115047 @default.
• W3114339968 cites W2019300123 @default.
• W3114339968 cites W2029182084 @default.
• W3114339968 cites W2052923174 @default.
• W3114339968 cites W2052992787 @default.
• W3114339968 cites W2054271839 @default.
• W3114339968 cites W2064076956 @default.
• W3114339968 cites W2075485349 @default.
• W3114339968 cites W2085025468 @default.
• W3114339968 cites W2087760712 @default.
• W3114339968 cites W2088303839 @default.
• W3114339968 cites W2089435027 @default.
• W3114339968 cites W2095322130 @default.
• W3114339968 cites W2100091063 @default.
• W3114339968 cites W2110109090 @default.
• W3114339968 cites W2119347018 @default.
• W3114339968 cites W2121422103 @default.
• W3114339968 cites W2123782121 @default.
• W3114339968 cites W2131078911 @default.
• W3114339968 cites W2132752715 @default.
• W3114339968 cites W2136185225 @default.
• W3114339968 cites W2138465150 @default.
• W3114339968 cites W2140621953 @default.
• W3114339968 cites W2143783309 @default.
• W3114339968 cites W2144971762 @default.
• W3114339968 cites W2146657064 @default.
• W3114339968 cites W2159899308 @default.
• W3114339968 cites W2165566667 @default.
• W3114339968 cites W2167086724 @default.
• W3114339968 cites W2279003811 @default.
• W3114339968 cites W2338681188 @default.
• W3114339968 cites W2346828652 @default.
• W3114339968 cites W2587835995 @default.
• W3114339968 cites W2623854426 @default.
• W3114339968 cites W2792663949 @default.
• W3114339968 cites W2895786705 @default.
• W3114339968 cites W2972576282 @default.
• W3114339968 cites W2983512221 @default.
• W3114339968 cites W3021651326 @default.
• W3114339968 doi "https://doi.org/10.1016/j.mehy.2020.110457" @default.
• W3114339968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33406471" @default.
• W3114339968 hasPublicationYear "2021" @default.
• W3114339968 type Work @default.
• W3114339968 sameAs 3114339968 @default.
• W3114339968 citedByCount "5" @default.
• W3114339968 countsByYear W31143399682021 @default.
• W3114339968 countsByYear W31143399682022 @default.
• W3114339968 countsByYear W31143399682023 @default.
• W3114339968 crossrefType "journal-article" @default.
• W3114339968 hasAuthorship W3114339968A5086988650 @default.
• W3114339968 hasAuthorship W3114339968A5091158883 @default.
• W3114339968 hasConcept C126322002 @default.
• W3114339968 hasConcept C126838900 @default.
• W3114339968 hasConcept C143409427 @default.
• W3114339968 hasConcept C146638467 @default.
• W3114339968 hasConcept C164705383 @default.
• W3114339968 hasConcept C178853913 @default.
• W3114339968 hasConcept C2779134260 @default.
• W3114339968 hasConcept C2779483572 @default.
• W3114339968 hasConcept C71924100 @default.
• W3114339968 hasConceptScore W3114339968C126322002 @default.
• W3114339968 hasConceptScore W3114339968C126838900 @default.
• W3114339968 hasConceptScore W3114339968C143409427 @default.
• W3114339968 hasConceptScore W3114339968C146638467 @default.
• W3114339968 hasConceptScore W3114339968C164705383 @default.
• W3114339968 hasConceptScore W3114339968C178853913 @default.
• W3114339968 hasConceptScore W3114339968C2779134260 @default.
• W3114339968 hasConceptScore W3114339968C2779483572 @default.
• W3114339968 hasConceptScore W3114339968C71924100 @default.
• W3114339968 hasLocation W31143399681 @default.
• W3114339968 hasOpenAccess W3114339968 @default.
• W3114339968 hasPrimaryLocation W31143399681 @default.
• W3114339968 hasRelatedWork W1521585289 @default.
• W3114339968 hasRelatedWork W2053682005 @default.
• W3114339968 hasRelatedWork W2065184126 @default.
• W3114339968 hasRelatedWork W2127987021 @default.
• W3114339968 hasRelatedWork W2141588638 @default.
• W3114339968 hasRelatedWork W2165566667 @default.
• W3114339968 hasRelatedWork W2326017766 @default.
• W3114339968 hasRelatedWork W2784969266 @default.
• W3114339968 hasRelatedWork W313460363 @default.
• W3114339968 hasRelatedWork W4294163823 @default.
• W3114339968 hasVolume "146" @default.
• W3114339968 isParatext "false" @default.
• W3114339968 isRetracted "false" @default.
• W3114339968 magId "3114339968" @default.

• next