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• W3114429589 abstract "Background Guidelines recommend that individuals with opioid use disorder (OUD) receive pharmacological and psychosocial interventions; however, the most appropriate psychosocial intervention is not known. In collaboration with people with lived experience, clinicians, and policy makers, we sought to assess the relative benefits of psychosocial interventions as an adjunct to opioid agonist therapy (OAT) among persons with OUD. Methods A review protocol was registered a priori (CRD42018090761), and a comprehensive search for randomized controlled trials (RCT) was conducted from database inception to June 2020 in MEDLINE, Embase, PsycINFO and the Cochrane Central Register of Controlled Trials. Established methods for study selection and data extraction were used. Primary outcomes were treatment retention and opioid use (measured by urinalysis for opioid use and opioid abstinence outcomes). Odds ratios were estimated using network meta-analyses (NMA) as appropriate based on available evidence, and in remaining cases alternative approaches to synthesis were used. Results Seventy-two RCTs met the inclusion criteria. Risk of bias evaluations commonly identified study limitations and poor reporting with regard to methods used for allocation concealment and selective outcome reporting. Due to inconsistency in reporting of outcome measures, only 48 RCTs (20 unique interventions, 5,404 participants) were included for NMA of treatment retention, where statistically significant differences were found when psychosocial interventions were used as an adjunct to OAT as compared to OAT-only. The addition of rewards-based interventions such as contingency management (alone or with community reinforcement approach) to OAT was superior to OAT-only. Few statistically significant differences between psychosocial interventions were identified among any other pairwise comparisons. Heterogeneity in reporting formats precluded an NMA for opioid use. A structured synthesis was undertaken for the remaining outcomes which included opioid use (n = 18 studies) and opioid abstinence (n = 35 studies), where the majority of studies found no significant difference between OAT plus psychosocial interventions as compared to OAT-only. Conclusions This systematic review offers a comprehensive synthesis of the available evidence and the limitations of current trials of psychosocial interventions applied as an adjunct to OAT for OUD. Clinicians and health services may wish to consider integrating contingency management in addition to OAT for OUD in their settings to improve treatment retention. Aside from treatment retention, few differences were consistently found between psychosocial interventions adjunctive to OAT and OAT-only. There is a need for high-quality RCTs to establish more definitive conclusions. Trial registration PROSPERO registration CRD42018090761." @default.
• W3114429589 created "2021-01-05" @default.
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• W3114429589 date "2020-12-28" @default.
• W3114429589 modified "2023-10-14" @default.
• W3114429589 title "Evaluating comparative effectiveness of psychosocial interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analyses" @default.
• W3114429589 cites W1593172493 @default.
• W3114429589 cites W1617328014 @default.
• W3114429589 cites W1702336527 @default.
• W3114429589 cites W1714487263 @default.
• W3114429589 cites W1946250460 @default.
• W3114429589 cites W1964032526 @default.
• W3114429589 cites W1965935619 @default.
• W3114429589 cites W1967385770 @default.
• W3114429589 cites W1968193935 @default.
• W3114429589 cites W1970131115 @default.
• W3114429589 cites W1974572686 @default.
• W3114429589 cites W1976355116 @default.
• W3114429589 cites W1977048103 @default.
• W3114429589 cites W1979110535 @default.
• W3114429589 cites W1982724855 @default.
• W3114429589 cites W1983925956 @default.
• W3114429589 cites W1985590886 @default.
• W3114429589 cites W1985718825 @default.
• W3114429589 cites W1987609279 @default.
• W3114429589 cites W1988466253 @default.
• W3114429589 cites W1990886388 @default.
• W3114429589 cites W1991476521 @default.
• W3114429589 cites W1992121056 @default.
• W3114429589 cites W1997938241 @default.
• W3114429589 cites W1998469387 @default.
• W3114429589 cites W1999048930 @default.
• W3114429589 cites W2004465231 @default.
• W3114429589 cites W2008907286 @default.
• W3114429589 cites W2016978020 @default.
• W3114429589 cites W2020713284 @default.
• W3114429589 cites W2024859219 @default.
• W3114429589 cites W2028915915 @default.
• W3114429589 cites W2029551284 @default.
• W3114429589 cites W2029915685 @default.
• W3114429589 cites W2031253041 @default.
• W3114429589 cites W2033262426 @default.
• W3114429589 cites W2045066965 @default.
• W3114429589 cites W2048135932 @default.
• W3114429589 cites W2049782579 @default.
• W3114429589 cites W2052473931 @default.
• W3114429589 cites W2052591381 @default.
• W3114429589 cites W2057327509 @default.
• W3114429589 cites W2060879859 @default.
• W3114429589 cites W2063343624 @default.
• W3114429589 cites W2079407117 @default.
• W3114429589 cites W2083343730 @default.
• W3114429589 cites W2087280110 @default.
• W3114429589 cites W2088307018 @default.
• W3114429589 cites W2091092767 @default.
• W3114429589 cites W2091808438 @default.
• W3114429589 cites W2098923148 @default.
• W3114429589 cites W2102891302 @default.
• W3114429589 cites W2109551625 @default.
• W3114429589 cites W2117682297 @default.
• W3114429589 cites W2118296568 @default.
• W3114429589 cites W2127117318 @default.
• W3114429589 cites W2129821518 @default.
• W3114429589 cites W2131107869 @default.
• W3114429589 cites W2137289515 @default.
• W3114429589 cites W2141270560 @default.
• W3114429589 cites W2145179206 @default.
• W3114429589 cites W2145555293 @default.
• W3114429589 cites W2147802232 @default.
• W3114429589 cites W2148964257 @default.
• W3114429589 cites W2150622631 @default.
• W3114429589 cites W2151383246 @default.
• W3114429589 cites W2153599479 @default.
• W3114429589 cites W2156100542 @default.
• W3114429589 cites W2163293508 @default.
• W3114429589 cites W2169255825 @default.
• W3114429589 cites W2170641476 @default.
• W3114429589 cites W2296986887 @default.

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